[1]蔡加炉,王 成,汪俊军.循环微小核糖核酸与2型糖尿病的关系[J].现代检验医学杂志,2015,30(03):5-5.[doi:10.3969/j.issn.1671-7414.2015.03.002]
 CAI Jia-lu,WANG Cheng,WANG Jun-jun.Relationship between Circulating miRNA and Type 2 Diabetes[J].Journal of Modern Laboratory Medicine,2015,30(03):5-5.[doi:10.3969/j.issn.1671-7414.2015.03.002]
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循环微小核糖核酸与2型糖尿病的关系()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年03期
页码:
5-5
栏目:
述评
出版日期:
2015-06-10

文章信息/Info

Title:
Relationship between Circulating miRNA and Type 2 Diabetes
文章编号:
1671-7414(2015)03-005-04
作者:
蔡加炉王 成汪俊军
南京军区南京总医院临床检验科,南京 210002
Author(s):
CAI Jia-luWANG ChengWANG Jun-jun
Department of Clinical Laboratory, Nanjing General Hospital of Nanjing Military Region,PLA,Nanjing 210002,China
关键词:
2型糖尿病 微小核糖核酸 血清 生物标志物
分类号:
587.1; R392.11
DOI:
10.3969/j.issn.1671-7414.2015.03.002
文献标志码:
A
摘要:
微小核糖核酸(microRNA,miRNA)是一类非编码小分子RNA,广泛参与基因转录后水平调控,在细胞增殖、分化、凋亡和代谢等过程中发挥重要作用。不同病理和生理状态,机体多种组织和细胞能分泌或释放特定miRNA进入血循环,并传递至受体细胞发挥生物学功能。最新研究表明,miRNA广泛参与2型糖尿病的发生、发展过程。循环miRNA由于来源广泛,稳定性高,同时在不同生理或病理情况下会发生特征性改变,有可能作为2型糖尿病新型标志物并参与2型糖尿病发生发展。
Abstract:
MicroRNAs(miRNAs)are a class of small non-coding RNA that regulate gene expression at the posttranscriptional level and playimportant roles in cell proliferation,differentiation,apoptosis and metabolism.Moreover,specific miRNAs can be secreted or released from tissues and cells in different physiological or pathological statusand enteredinto blood circulation,and secreted miRNAs can be delivered into recipient cells and emerged as powerful regulatorsof a wide range of biological processes.Many recent studieshaveshown that miRNAswere involved in the development and progression of type 2 diabetes(T2DM).Due to the widely source,highly stability,and specific expressionpatternunder different physiological or pathological conditions,circulating miRNAs may serve as a novelbiomarker for T2DM and may also participate in the development of type 2 diabetes.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81271904); 国家重大科学仪器设备开发专项基金(2012YQ03026109)。
作者简介:蔡加炉(1988-),男,在读研究生,主要研究血清miRNA和血清脂蛋白。
通讯作者:汪俊军,E-mail:jjwang9202@163.com。
更新日期/Last Update: 2015-06-10