[1]陈柳青,连炬飞,曾 丽,等.探讨BA,EMAb及ACA与不明原因复发性自然流产的相关性[J].现代检验医学杂志,2015,30(04):137-140.[doi:10.3969/j.issn.1671-7414.2015.04.042]
 CHEN Liu-qing,LIAN Ju-fei,ZENG Li,et al.Discussing the Correlation between BA,EMAb, ACA and Unexplained Recurrent Spontaneous Abortion[J].Journal of Modern Laboratory Medicine,2015,30(04):137-140.[doi:10.3969/j.issn.1671-7414.2015.04.042]
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探讨BA,EMAb及ACA与不明原因复发性自然流产的相关性()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年04期
页码:
137-140
栏目:
检验与临床
出版日期:
2015-08-10

文章信息/Info

Title:
Discussing the Correlation between BA,EMAb, ACA and Unexplained Recurrent Spontaneous Abortion
文章编号:
1671-7414(2015)04-137-04
作者:
陈柳青连炬飞曾 丽赖科峰林 珠
广东省妇幼保健院检验科,广州 510010
Author(s):
CHEN Liu-qingLIAN Ju-feiZENG LiLAI Ke-fengLIN Zhu
Department of Clinical Laboratory, Guangdong Women and Children Hospital,Guangzhou 510010,China
关键词:
封闭抗体 抗子宫内膜抗体 抗心磷脂抗体 不明原因复发性自然流产
分类号:
R714.21; R392.11
DOI:
10.3969/j.issn.1671-7414.2015.04.042
文献标志码:
A
摘要:
目的 探讨封闭抗体(BA),抗子宫磷脂抗体(EMAb)及抗心磷脂抗体(ACA)联合检测与不明原因复发性自然流产(UPSA)的相关性。方法 选取不明原因复发性自然流产144例,偶发性自然流产166例和正常体检孕妇188例,检测其BA,EMAb和ACA并行统计学分析。结果 URSA组分别与偶发性自然流产组及对照组相比较,BA阴性率(74.31%,25.30%和50.53%),EMAb阳性率(35.42%,7.23%和6.91%)和ACA阳性率(26.39%,5.42%和5.32%)差异均有统计学意义(χ2=19.344~74.180,P值均<0.05; χ2=37.837~42.586,P值均<0.05; χ2=26.355~29.270,P值均<0.05)。URSA组的BA,EMAb和ACA联合检测阳性率(84.72%)明显高于偶发性自然流产组及对照组(χ2=35.532~93.076,P值均<0.05)。结论 BA的缺乏,EMAb和ACA的产生与不明原因复发性自然流产存在密切的关系,联合检测对辅助诊断URSA及其预后判断具有重要的临床指导意义。
Abstract:
Objective To discuss the correlation betweenthe joint detection of BA,EMAb,ACA and unexplained recurrent spontaneous abortion(URSA).Methods Selected 144 URSA cases,166 SA(sporadic abortion)cases,188 normal pregnant women,and detected their BA,EMAb,ACA and statistical analysis of parallelism.Results Comparing URSA group with SA group and control group respectively,there were significant statistical difference between BA negative rate(74.31%,25.30% and 50.53%),EMAb positive rate(35.42%,7.23% and 6.91%)and ACA positive rate(26.39%,5.42% and 5.32%)(χ2=19.344~74.180; P<0.05; χ2=37.837~42.586,P<0.05),(χ2=26.355~29.270,P<0.05).URSA group's BA,ACA and EMAb joint detection rate of positive(84.72%)was significantly higher than SA group and the control group(χ2=35.532~93.076,P<0.05).ConclusionThere was a close relationship between the lack of BA,the generationof EMAb,ACA and unexplained recurrent spontaneous abortion.Joint detection hasimportant clinical significance in auxiliary diagnosis of unexplained recurrentspontaneous abortion and prognosis judgement.

参考文献/References:

[1] Choi TY,Lee HM,Park WK,et al.Spontaneous abortion and recurrent miscarriage:A comparison of cytogenetic diagnosis in 250 cases[J].ObstetGynecol Sci,2014,57(6):518-525.
[2] Sereshki N,Gharagozloo M,Ostadi V,et al.Variations in T-helper 17 and regulatory T cells during the menstrual cycle in peripheral blood of women with recurrent spontaneous abortion[J].Int J Fertil Steril,2014,8(1):59-66.
[3] Wu L,Luo LH,Zhang YX,et al.Alteration of Th17 and Treg cells in patients with unexplained recurrent spontaneous abortion before and after lymphocyteimmunization therapy[J].Reprod Biol Endocrinol,2014(12):74.
[4] 张劲丰,杨延斌,苏 荣,等.封闭抗体在不同孕育状态妇女中的分布规律[J].中国妇幼保健,2013,28(2):298-300.
Zhang JF,Yang YB,Su R,et al.The study on the distribution of block antibody among the women in different breed status[J].Maternal and Child Health Care of China,2013,28(2):298-300.
[5] 郭 虹,杨 华,王维鹏.反复自然流产中封闭抗体、抗心磷脂抗体检测的临床意义[J].国际检验医学杂志,2013,34(7):773,775.
Guo H,Yang H,Wang WP.Significance of blocking antibody and anticardiolipin antibody in patients with recurrent spontaneous abortion[J].Int J Lab Med,2013,34(7):773,775.
[6] Sarapik A,Haller-Kikkatalo K,Utt M,et al.Serum anti-endometrial antibodies in infertile women-potential risk factor for implantation failure [J].Am J Reprod Immunol,2010,63(5):349-357.
[7] 孙 娜,张文静,高 飞,等.β2 GPⅠ及其抗体与抗磷脂综合征的研究进展[J].现代检验医学杂志,2015,30(1):19-22.
Sun N,Zhang WJ,Gao F,et al.Research progress of β2 glycoproteinⅠ and anti-β2GPⅠ antibodies and antiphospholipid syndrome[J].Journal of Modern Laboratory Medicine,2015,30(1):19-22.
[8] 黄永富,王 冲.封闭抗体检测在复发性自然流产患者淋巴细胞主动免疫治疗中的应用[J].黑龙江医学,2014,38(4):364-368.
Huang YF,Wang C.Application of blocking antibody detection in lymphocyte active immunotherapy for recurrent spontaneous abortion patients[J].Heilongjiang Medicine Journal,2014,38(4):364-368.
[9] 高汉义,陶恩学,王 燕,等.调免3号对封闭抗体缺乏型反复自然流产免疫调节作用[J].中国中西医结合杂志,2012,32(6):766-769.
Gao HY,Tao EX,Wang Y,et al.Immunoregulation effects of TiaomianNo.3 for recurrent spontaneous abortion caused by shortage of blocking antibodies[J].Chinese Journal of Integrated Traditional and Western Medicine,2012,32(6):766-769.
[10] 于红玲,邓晓惠,晁 岚,等.配偶淋巴细胞免疫治疗次数和注射方式对复发性流产患者封闭抗体阳转率的影响[J].中华妇产科杂志,2013,48(12):903-906.
Yu HL,Deng XH,Chao L,et al.Study on positive rate of blocking antibodyin women with recurrent spontaneous abortion administered by route and frequency of paternal lymphocyte immunotherapy[J].Chinese Journal of Obstetrics and Gynecology,2013,48(12):903-906.
[11] 陈海玲,宁学玲.抗子宫内膜抗体和抗精子抗体对不孕者和习惯性流产者的检测及临床探讨[J].吉林医学,2013,34(16):3090-3092.
Chen HL,Ning XL.Detection and clinical discussion of the EMAB and ASABto the infertility,habitual abortion[J].Jilin Medical Journal,2013,34(16):3090-3092.
[12] Collazo MS, Porrata-Doria T, Flores I,et al.Apolipoprotein E polymorphisms and spontaneous pregnancy loss in patients with endometriosis[J].Mol Hum Reprod,2012,18(7):372-377.
[13] Lacroix O,Despierres L,Courbiere B,et al.Antipho-spholipid antibodiesin women undergoing in vitro fertilization treatment: clinical value of IgA anti-β2 glycoprotein I antibodies determination[J].Biomed Res Int,2014(2014):314704.
[14] Suh-Lailam BB, Cromar A, Davis KW,et al.APhL antibody ELISA as an alternative to anticardiolipin test for the diagnosis of antiphospholipid syndrome[J].Int J Clin Exp Pathol,2012,5(3):210-215.
[15] Ciesla M,Wypasek E,Undas A.IgA antiphospholipid antibodies and anti-domain 1 of beta 2 glycoprotein 1 antibodies are associated with livedo reticularis and heart valve disease in antiphospholipid syndrome[J].Adv Clin Exp Med,2014,23(5):729-733.
[16] Al Samarrai AA, Hilmi FA, Al-Allawi NA,et al.Antiphospholipid antibodies in iraqi women with recurrent mid-trimester abortions[J].J Lab Physicians,2012,4(2):78-82.

备注/Memo

备注/Memo:
基金项目:广东省中医药局(20122175),五干颗粒对封闭抗体缺乏所致复发性流产患者的临床观察。
作者简介:陈柳青(1981-),女,学士,主管技师,从事临床检验,血液检验,生化检验等,Tel:18620082317,E-mail:chenliuqing2000@163.com。
更新日期/Last Update: 2015-08-10