[1]徐晓嵘a,章晓鹰a,张珏a,等.干扰素治疗慢性乙型肝炎HBeAg血清学转换预测指标价值比较[J].现代检验医学杂志,2015,30(05):146-147.[doi:10.3969/j.issn.1671-7414.2015.05.046]
　XU Xiao-ronga,ZHANG Xiao-yinga,ZHANG Juea,et al.Comparison of the Values for Predicting HBeAg Seroconversion in the Treatment of Chronic Hepatitis B by PEG-IFN[J].Journal of Modern Laboratory Medicine,2015,30(05):146-147.[doi:10.3969/j.issn.1671-7414.2015.05.046]
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干扰素治疗慢性乙型肝炎HBeAg血清学转换预测指标价值比较()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年05期
页码:
146-147
栏目:
检验与临床
出版日期:
2015-12-10

文章信息/Info

Title:
Comparison of the Values for Predicting HBeAg Seroconversion in the Treatment of Chronic Hepatitis B by PEG-IFN
作者:
徐晓嵘a; 章晓鹰a; 张珏a; 吕佳b
上海中医药大学附属曙光医院a.检验科；b.肝炎科，上海201203
Author(s):
XU Xiao-ronga; ZHANG Xiao-yinga; ZHANG Juea; L Jiab
a.Department of Clinical Laboratory；b.Department of Hepatology，Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai 201203，China
关键词:
慢性乙型肝炎; 干扰素; ROC曲线; 灵敏度; 特异度
分类号:
R512.62；R446.61
DOI:
10.3969/j.issn.1671-7414.2015.05.046
文献标志码:
A
摘要:
目的比较乙型肝炎表面抗原(HBsAg)、乙型肝炎e抗原(HBeAg)与乙肝病毒DNA (HBV-DNA)对干扰素治疗HBeAg阳性慢性乙型肝炎48周HBeAg血清学转换的临床预测价值。方法252例接受干扰素治疗的HBeAg阳性慢性乙型肝炎患者为研究对象，分为HBeAg血清学转换组(83例)与未转换组(169例)。利用受试者工作特征(ROC)曲线计算灵敏度、特异度、阳性预测值(PPV)与阴性预测值(NPV)。结果12周与24周HBeAg分别以90 S/CO与25 S/CO为临界值时，其预测治疗48周HBeAg血清学转换的灵敏度、特异度、PPV，NPV分别为0.852，0.639，0.680，0.828与0.899，0.663，0.763，0.845，24周的HBV-DNA载量与较基线下降幅度也具有较高灵敏度与特异度。结论HBeAg血清定量值为干扰素治疗慢性乙型肝炎血清学转换最佳预测指标，此外，治疗24周HBV-DNA载量与较基线下降幅度也具有一定预测价值。
Abstract:
ObjectiveTo compare the clinical value of quantitative serum hepatitis B surface antigen (HBsAg)，hepatitis B e-antigen (HBeAg) and hepatitis B virus (HBV-DNA) for predicting HBeAg seroconversion in the treatment of HBeAg-positive chronic hepatitis B (CHB) by pegylated interferon (PEG-IFN)．Methods252 HBeAg-positive chronic hepatitis B patients who received PEG-IFN were enrolled．They were divided in HBeAg seroconversion group (83 cases) and non- HBeAg seroconversion group (169 cases)．Sensitivity，specificity，positive predictive value (PPV) and negative predictive value (NPV) were calculated by receiver operating characteristic (ROC) curve．ResultsWhen cut-off point of HBeAg was set to 90 S/CO for 12 weeks and 25 S/CO for 24 weeks，the sensitivity，specificity，PPV and NPV of HBeAg seroconversion after 48 weeks treatment were 0.852，0.639，0.680，0.828 and 0.899，0.663，0.763，0.845 respectively．At week 24 of treatment，HBV-DNA load and decline also had higher sensitivity and specificity．ConclusionSerum of HBeAg level was strong predictor factor for HBeAg seroconversion，HBV-DNA and decline also had higher predictive value at week 24 of treatment．

参考文献/References:

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[7]张健，张艳茹，李威，等．慢性乙型肝炎患者干扰素治疗过程中出现HBeAg/ 抗HBe双阳性现象的临床分析［J］．热带医学杂志，2013，13(4)：446-448． Zhang J，Zhang YR，Li W，et al．Clinical characteristics of chronic hepatitis B with concurrent hepatitis B e antigen and antibody detection during the treatment with interferon alpha［J］．Journal of Tropical Medicine，2013，13(4)：446-448．

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备注/Memo

备注/Memo:
作者简介：徐晓嵘(1981-)女，大学本科，主要从事临床医学检验工作，Tel：13918649500，E-mail：84148379@qq.com。 通讯作者：章晓鹰，主任技师，E-mail：zhangxy10@126.com。
更新日期/Last Update: 1900-01-01