[1]归巧娣,苍金荣,宫艳艳,等.西安地区育龄妇女MTHFRC677T基因型分布研究[J].现代检验医学杂志,2015,30(06):39-41.[doi:10.3969/j.issn.1671-7414.2015.06.011]
 GUI Qiao-di,CANG Jin-rong,GONG Yan-yan,et al.Geographical Distribution of MTHFRC677T Gene among the Gestational Age Women in Xi’an[J].Journal of Modern Laboratory Medicine,2015,30(06):39-41.[doi:10.3969/j.issn.1671-7414.2015.06.011]
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西安地区育龄妇女MTHFRC677T基因型分布研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年06期
页码:
39-41
栏目:
论著
出版日期:
2015-12-30

文章信息/Info

Title:
Geographical Distribution of MTHFRC677T Gene among the Gestational Age Women in Xi’an
作者:
归巧娣苍金荣宫艳艳高明华
陕西省人民医院检验科,西安710068
Author(s):
GUI Qiao-diCANG Jin-rongGONG Yan-yanGAO Ming-hua
Department of Clinical Laboratory, Shaanxi Provincial People’s Hospital,Xi'an 710068,China
关键词:
育龄妇女亚甲基四氢叶酸还原酶C677T基因型
分类号:
Q786
DOI:
10.3969/j.issn.1671-7414.2015.06.011
文献标志码:
A
摘要:
目的拟检测西安地区育龄妇女亚甲基四氢叶酸还原酶(MTHFR)C677T基因,了解该地区该基因突变情况,以期指导孕妇根据MTHFRC677T基因型合理补充叶酸,从而降低新生儿的出生缺陷率。方法采用现况研究方法,以西安地区3 492例育龄女性为研究对象,通过PCR基因芯片技术检测MTHFRC677T基因,统计分析该地区基因多态性的分布特征,并与已报道其他地区MTHFRC677T基因结果进行比较。结果西安地区女性的MTHFRC677T基因CC型,CT型和TT型频率分别为22.91%,48.97%和28.12%,以CT型为主。不同年龄段和不同孕周妇女MTHFRC677T基因无差异(P>0.05)。与文献报道全国多地MTHFR基因型比较,西安地区与郑州MTHFR基因型差异无统计学意义(χ2=3.345,P>0.05),与淄博、临沂、德阳、松滋、武汉、镇江、惠州、昆明、广东、琼海和海南差异均有统计学意义(P>0.05)。结论西安地区女性MTHFRC677T基因多态性分布具有地域特异性,以CT型为主。
Abstract:
ObjectiveTo explore the genotype distribution of methylenetetrahydrofolate reductase (MTHFR)among gestational-age women in Xi’an.Methods3 492 samples were recruited from Xi'an.The samples were collected and genomic DNA was isolated.The detections of MTHFRC677T genes were conducted with PCR gene chip technology.The distribution of gene polymorphisms of this study was analyzed and compared with some reported regions of China.ResultsThe frequency of MTHFR gene CC,CT and TT were 22.91%,48.97% and 28.12% respectively in Xi'an.There were no different of age and pregnant weeks among the women in Xi'an.This study suggested that the gene polymorphism of MTHFR among the women in Xi’an was statistically different from some other regions of China except of Zhenzhou.ConclusionThe distribution of MTHFRC677T in Xi’an has regional specificity,the gene of CT was mainly type.

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备注/Memo

备注/Memo:
收稿日期:2015-03-23修回日期:2015-07-04西安地区育龄妇女MTHFRC677T基因型分布研究作者简介:归巧娣(1978-),女,硕士研究生,副主任医师,主要从事临床微生物研究,Tel:13649200365。
更新日期/Last Update: 1900-01-01