[1]余安运,陶丹,刘夏炎,等.肿瘤标志物在消化系统肿瘤早期诊断中的应用[J].现代检验医学杂志,2015,30(06):133-135.[doi:10.3969/j.issn.1671-7414.2015.06.041]
　YU An-yun,TAO Dan,LIU Xia-yan,et al.Clinical Value of Blood Serums Tumor Marker in Early Diagnosis of Digestive System Neoplasms[J].Journal of Modern Laboratory Medicine,2015,30(06):133-135.[doi:10.3969/j.issn.1671-7414.2015.06.041]
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肿瘤标志物在消化系统肿瘤早期诊断中的应用()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年06期
页码:
133-135
栏目:
检验与临床
出版日期:
2015-12-30

文章信息/Info

Title:
Clinical Value of Blood Serums Tumor Marker in Early Diagnosis of Digestive System Neoplasms
作者:
余安运1; 陶丹2; 刘夏炎1; 徐晖1
1.陕西省康复医院检验科，西安710065； 2.西安交通大学医学院第一附属医院检验科，西安710061
Author(s):
YU An-yun1; TAO Dan2; LIU Xia-yan1; XU Hui1
1.Department of Clinical Laboratory， Shaanxi Kangfu Hospital，Xi’an 710065，China；2.Department of Clinical Laboratory,the First Affiliated Hospital of Medical College of Xi’an Jiaotong University，Xi’an 710061，China
关键词:
肿瘤标志物; 消化系统; 恶性肿瘤
分类号:
R735；R730
DOI:
10.3969/j.issn.1671-7414.2015.06.041
文献标志码:
A
摘要:
目的探讨血清肿瘤标志物在消化系统恶性肿瘤中的应用价值。方法采用电化学发光仪检测224例消化系统恶性肿瘤患者和103例健康对照者血清中六种肿瘤标志物：甲胎蛋白(AFP)，糖类抗原125(CA-125)，糖类抗原199(CA-199)，癌胚抗原(CEA)，细胞角蛋白 21-1(CYFRA21-1)和转铁蛋白(Ferritin)，对比两组检测结果的差异及其灵敏度和特异度。结果①肿瘤组六种肿瘤标志物AFP，CA125，CA199，CEA，CYFRA21-1和Ferritin水平均高于对照组(Z=-2.174，-1.917，-3.012，-2.122，-1.954，-2.997；P=0.037，0.000，0.000，0.000，0.000，0.000)。②消化肿瘤组中AFP，CA125，CA199，CEA，CYFRA21-1和Ferritin六种标志物阳性率较对照组差异均有统计学显著性意义(χ2=31.23，23.63，36.89，29.12，30.11，27.18；P=0.002，0.000，0.000，0.000，0.000，0.000)，CA-199阳性率最高(50.45%)。③六种血清肿瘤标记物在消化系统肿瘤中的灵敏度、特异度和准确度不同，消化系统肿瘤以CEA+CA-199+AFP和CEA+CA-125+CA-199联合较与其他标志物联合敏感度(70.98%，70.98%)，特异度(92.23%，85.44%)更高。结论血清肿瘤标志物对消化系统恶性肿瘤的诊断具有积极的作用，其可提高恶性肿瘤的早期检出率。
Abstract:
ObjectiveTo investigate the clinical value of blood serums tumor markers in malignant neoplasms of digestive system．MethodsElectrochemiluminescence immunization method was performed to detect the levels of six tumor biochemical markers，including carcinoembryonic antigen (CEA)，neuron-specific enolase (NSE)，cytokeratin 19 (CYFRA21-1)，Alpha-fetoprotein (AFP)，carbohydrate antigen-125 (CA-125)，carbohydrate antigen-199 (CA-199) and Ferritin，in 224 cancer patients and in 103 healthy subjects for comparison．To contrast the sensitivity and specificity between different groups．Results①The levels of six markers in cancer patients were higher than those in healthy subjects (Z=-2.174，-1.917，-3.012，-2.122，-1.954，-2.997；P=0.037，0.000，0.000，0.000，0.000，0.000)．②The ratios of positive diagnosis of six tumor biochemical markers in malignant neoplasms of digestive system were higher than those in healthy subjects (χ2=31.23，23.63，36.89，29.12，30.11，27.18；P=0.002，0.000，0.000，0.000，0.000，0.000)．The positive rate of CA199 (50.45%) was the highest then others．③Sensitivity，specificity and accuracy of six tumor biochemical markers were different．Sensitivity and specificity of CEA+CA-199+AFP and CEA+CA-125+CA-199 were thehighest then others．ConclusionCombining tumor markers may play an important role in early tumor detection/diagnosis if the loss of specificity can be solved．

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备注/Memo

备注/Memo:
作者简介：余安运(1962-)，男，本科，副主任技师，主要从事生化及临床实验室诊断的研究，E-mail：13991968072@163.com。
更新日期/Last Update: 1900-01-01