[1]陈晓婷,李云飞,张炳峰.南京地区8 442例健康成人Lp(a)水平调查分析[J].现代检验医学杂志,2016,31(01):140-143.[doi:10.3969/j.issn.1671-7414.2016.01.041]
　CHEN Xiao-ting,LI Yun-fei,ZHANG Bing-feng.Investigation of Lipoprotein(a)Levels in 8 442 Adults in Nanjing[J].Journal of Modern Laboratory Medicine,2016,31(01):140-143.[doi:10.3969/j.issn.1671-7414.2016.01.041]
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南京地区8 442例健康成人Lp(a)水平调查分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年01期
页码:
140-143
栏目:
检验与临床
出版日期:
2016-01-25

文章信息/Info

Title:
Investigation of Lipoprotein(a)Levels in 8 442 Adults in Nanjing
作者:
陈晓婷; 李云飞; 张炳峰
南京医科大学第一附属医院检验学部,南京 210029
Author(s):
CHEN Xiao-ting; LI Yun-fei; ZHANG Bing-feng
Department of Medical Laboratory, the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China
关键词:
脂蛋白a;  冠状动脉粥样硬化性心脏病;  年龄因素;  性别因素
分类号:
R446.112
DOI:
10.3969/j.issn.1671-7414.2016.01.041
文献标志码:
A
摘要:
目的 分析南京地区健康人群血清脂蛋白(a)[lipoprotein(a),Lp(a)]水平与年龄、性别之间的关系。方法 收集2014年在南京医科大学第一附属医院体检的8 442份血清样本,采用胶乳增强免疫比浊法检测Lp(a),依性别和年龄分组,年龄分成6个组:15～29,30～44,45～59,60～69,70～79和≥80岁。采用SPSS21.0软件进行统计分析。结果 女性总体Lp(a)水平[134±197mg/L(M±QR,下同)]高于男性(126±178 mg/L),差异有统计学意义(U=8 355 137,P<0.001)。不同性别人群中,Lp(a)水平与年龄呈弱相关性(r=0.154,P<0.001),随年龄组增大Lp(a)水平有升高的趋势。男性1～6组Lp(a)分别为:106.5±151.0,119.0±170.0,128.0±179.0,159.0±206.0,145.0±200.0和162.0±190.0 mg/L,1,2组、2,3组、3,4组间比较差异有统计学意义(U分别为645 152.5,1 006 572.0和197 595.0; P均<0.05),4,5组、5,6组间比较差异无统计学意义(U分别为59 127.0和15 959.5; P均>0.05); 女性1～6组Lp(a)分别为:128.0±194.0,128.0±187.0,139.0±207.0,157.0±228.0,173.5±227.0和150.0±201.0 mg/L,2,3组间比较差异有统计学意义(U为641 147,P为0.006),1,2组、3,4组、4,5组、5,6组间比较差异无统计学意义(U分别为783 676,92 442.5,16 069.5和3 038; P均>0.05)。结论 南京地区健康人群Lp(a)水平与性别、年龄有关,有必要建立不同的参考区间。
Abstract:
Objective To explore the relationship between Lp(a)level and age,gender in Nanjing area.Methods 8 442 serum specimens from examination individuals were collected in the First Affiliated Hospital of Nanjing Medical University in 2014.Lp(a)was measured by immune turbidimetry method.All the subjects were divided into six groups:15～29,30～44,45～59,60～69,70～79 and ≥80 years old.SPSS21.0 software was usedto carry out statistics.Results The Lp(a)level in female [134±197 mg/L(M±QR,the same below)] was higher than that in male significantly(U=8 355 137,P<0.001).LP(a)levels from people of different sexcorrelated with the age weakly(r=0.154,P<0.001),and increased with agegroups.Lp(a)of six groups in male were 106.5±151.0,119.0±170.0,128.0±179.0,159.0±206.0,145.0±200.0 and 162.0±190.0 mg/L respectively.The difference was statistically significant between between 1 and 2 groups,2 and 3 groups,3 and 4 groups,the U value were 645 152.5,1 006 572.0,197 595.0 respectively; P all<0.05.The difference was not statistically significant between 4 and 5 groups,5 and 6 groups,3 and 4 groups,the U value were 59 127.0 and 15 959.5 respectively,P>0.05.Lp(a)of six groups in female were 128.0±194.0,128.0±187.0,139.0±207.0,157.0±228.0,173.5±227.0 and 150.0±201.0 mg/L.The difference was statistically significant between 2 and 3 groups,the U value was 641 147,P=0.006,respectively.The difference was not statistically significant between 1 and 2 groups,3 and 4groups,4 and 5 groups,5 and 6 groups,the U value were 783 676,92 442.5,16 069.5 and 3 038,respectively; P all>0.05.Conclusion Lp(a)level in healthy population in Nanjing area is related to genderand age groups,it is necessary to establish different reference ranges.

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备注/Memo

备注/Memo:
作者简介:陈晓婷(1971-),女,硕士,主任技师,主要从事临床生物化学检验研究,E-mail:13851522791@163.com。 通讯作者:李云飞,E-mail:ccttnnhh@163.com
更新日期/Last Update: 2016-01-20