[1]戴 芳a,姜志茹b,孙艳荪b.选择性5-羟色胺再摄取抑制剂艾司西肽普兰对血小板功能的影响[J].现代检验医学杂志,2016,31(04):131-132,135.[doi:10.3969/j.issn.1671-7414.2016.04.037]
　DAI Fanga,JIANG Zhi-rub,SUN Yan-sunb.Effect of Selective Serotonin Reuptake Inhibitors Escitalopram to Platelet Function[J].Journal of Modern Laboratory Medicine,2016,31(04):131-132,135.[doi:10.3969/j.issn.1671-7414.2016.04.037]
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选择性5-羟色胺再摄取抑制剂艾司西肽普兰对血小板功能的影响()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年04期
页码:
131-132,135
栏目:
研究简报·实验技术
出版日期:
2016-08-10

文章信息/Info

Title:
Effect of Selective Serotonin Reuptake Inhibitors Escitalopram to Platelet Function
文章编号:
1671-7414(2016)04-131-03
作者:
戴 芳a; 姜志茹b; 孙艳荪b
北京大学深圳医院a.输血科;
b.特诊老年科,深圳 518036
Author(s):
DAI Fanga; JIANG Zhi-rub; SUN Yan-sunb
a.Department of Blood Transfusion;
b.the Special Clinic Department of Geriatrics,Shenzhen Hospital of Beijing University,Guangdong Shenzhen518036,China
关键词:
选择性5-羟色胺再摄取抑制剂;  艾司西肽普兰;  血小板
分类号:
R446.111
DOI:
10.3969/j.issn.1671-7414.2016.04.037
文献标志码:
A
摘要:
目的 观察选择性5-羟色胺再摄取抑制剂艾司西肽普兰对血小板功能的影响。方法 选取抑郁症患者61例,随机分为治疗组(艾司西酞普兰10 mg/日)和安慰剂对照组,测定治疗前后的血小板计数(PLT)、血小板平均体积(MPV)、血小板分布宽度(PDW)、血小板聚集率(PAR)、血小板膜糖蛋白CD62P和CD63表达。结果 治疗组在治疗前后的PLT(109/L),MPV(fl),PDW(fl),PAR(%),CD62P(%)和CD63(%)分别为175.8±59.1 vs 169.1±60.5,11.8±1.2 vs 10.3±0.9,15.6±2.1 vs 16.7±1.9,60.1±11.5 vs 59.3±14.9,23.8±5.6 vs25.1±3.7,20.6±7.2 vs 22.4±4.7,对照组在治疗前后的PLT(109/L),MPV(fl),PDW(fl),PAR(%),CD62P(%)和CD63(%)分别为198.6±76.5 vs 203.2±49.8,9.4±1.1 vs 10.2±0.8,12.5±1.8 vs 13.3±2.9,62.7±13.6 vs 66.4±10.7,27.9±7.1 vs 24.8±4.9,26.9±8.1 vs 24.1±6.4,差异均无统计学意义(均P>0.05)。结论 艾司西肽普兰对血小板功能无明显影响。
Abstract:
Objective To observe the effect of selective serotonin reuptake inhibitors Escitalopram on platelet function.Methods 61 depression patients were randomly divided into study group(Escitalopram 10 mg/d)and control group(placebo).The platelet count,mean platelet volume,platelet distribution width,platelet aggregation rate,platelet membrane glycoprotein CD62P and CD63 were measured before and after the therapy.Results There were no statistical difference in the level ofplatelet count,mean platelet volume,platelet distribution width,platelet aggregation rate,platelet membrane glycoprotein CD62P and CD63 between two groupsbefore and after the therapy.Conclusion There was no significant effect of Escitalopram on platelet function.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:深圳市科技计划项目(编号:JCYJ20150403091443306)。
作者简介:戴 芳(1962-),女,大学学历,副主任技师,主要研究方向自体输血及成分血液临床应用,Tel:13923796168,E-mail:4497846@qq.com。
更新日期/Last Update: 2016-08-10