[1]黄金文,李如凯,高 婧,等.孕妇血清半胱氨酸蛋白酶抑制剂C参考范围的研究[J].现代检验医学杂志,2016,31(04):133-135.[doi:10.3969/j.issn.1671-7414.2016.04.039]
 HUANG Jin-wen,LI Ru-kai,GAO Jing,et al.Study on the Reference Interval of Serum Cystatin C of Pregnant Women[J].Journal of Modern Laboratory Medicine,2016,31(04):133-135.[doi:10.3969/j.issn.1671-7414.2016.04.039]
点击复制

孕妇血清半胱氨酸蛋白酶抑制剂C参考范围的研究()
分享到:

《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年04期
页码:
133-135
栏目:
研究简报·实验技术
出版日期:
2016-08-10

文章信息/Info

Title:
Study on the Reference Interval of Serum Cystatin C of Pregnant Women
文章编号:
1671-7414(2016)04-133-03
作者:
黄金文李如凯高 婧吴少南
深圳市宝安区石岩人民医院检验科,广东深圳 518108
Author(s):
HUANG Jin-wenLI Ru-kaiGAO JingWU Shao-nan
Department of Clinical Laboratory, Shiyan People's Hospital of Shenzhen City Baoan District,Guangdong Shenzhen 518108,China
关键词:
孕妇 血清 半胱氨酸蛋白酶抑制剂C 参考范围
分类号:
R446.112
DOI:
10.3969/j.issn.1671-7414.2016.04.039
文献标志码:
A
摘要:
目的 建立孕妇妊娠早、中、晚期的血清半胱氨酸蛋白酶抑制物C(Cys C)参考范围。方法 采用免疫浊度法分析测定200例对照组女性(20~35岁),249例正常孕妇(20~35岁)妊娠早、中、晚期血清Cys C水平,并对数据进行统计学分析。结果 对照组、 妊娠早期、中期、晚期四组Cys C参考范围分别为0.46~0.95,0.45~0.85,0.52~0.90和0.75~1.48 mg/L,各组中位水平分别为0.56,0.58,0.62和0.9 mg/L,早期组、中期组与对照组中位水平,差异无统计学显著性意义(q=2.565,2.246,均P>0.05),对照组、早期、中期与晚期差异具有统计学显著性意义(q=5.346,6.070,5.766,均P<0.05)。结论 妊娠晚期血清Cys C水平升高,孕妇血清CysC参考范围应按照妊娠时间划分,有利于提高其临床价值和诊断的正确性。
Abstract:
Objective To establish the reference intervalsof Cystatin C(Cys C)in different pregnant stage of women including the first,the second and the last trimester.Methods The serum concentration of Cys C of 200 healthy,no-pregnant women and 249 healthy pregnantwomen in the three different pregnant stages aged from 20 to 35 was measured byimmunological turbidimetry,and the data was analyzed statistically.Results The reference intervals of Cys C of women in the contrast,the first,the second and the last trimester respectively was 0.46~0.95,0.45~0.85,0.52~0.90 and 0.75~1.48 mg/L,respectively.Each group's median was0.56,0.58,0.62 and 0.9 mg/L,and there was no statistical differenceamongthe first,the second trimester and the contrast(q=2.565,2.246,all P>0.05),but there was significant difference between the last trimester women and the others(q=5.346,6.070,5.766,all P<0.05).Conclusion The concentration of serum Cys C in womenat late pregnant stage was obviously higher.The reference interval of serum Cys C concentration of pregnant women is necessarily distinguished according to the pregnant stage,so that to improve its clinical value and diagnostic accuracy.

参考文献/References:

[1] 刘爱兵,李 玲,李红梅,等.北京地区健康人血浆胱抑素C水平及参考范围[J].现代检验医学杂志,2009,24(2):116-118. Liu AB,Li L,Li HM,et al.Plasma Cystatin C level and its reference interval in healthy volunteers in Beijing[J].Journal of Modern Laboratory,2009,24(2):116-118.
[2] 周 新, 府伟灵. 生物化学与生物化学检验[M].4版.北京:人民卫生出版社,1989:387-403. Zhou X,Fu WL.Biochemistry and Biochemistry Laboratory Medicine[M].4th Ed.Beijing:People's Health Publish Press,1989:387-403.
[3] 赵建军,朱 武.血清胱抑素C、同型半胱氨酸及尿微量清蛋白/肌酐比值在糖尿病肾病早期诊断中的应用[J].现代检验医学杂志,2014,29(2):117-120. Zhao JJ,Zhu W.Application of serum Cystatin C,Homocysteine,the ratio between microalbuminuria and creatinine in the early diagnosis of the diabetic nephrosis[J].Journal of Modern Laboratory Medicine,2014,29(2):117-120.
[4] 李海霞,张春丽,徐国宾,等.健康人群血清半胱氨酸蛋白酶抑制C与肌酐分布及其评价慢性肾脏病患者肾小球滤过功能的比较研究[J].中华检验医学杂志,2006,29(11):970-974. Li HX,Zhang CL,Xu GB,et al.Reference values of serum Cystatin Cand creatinine in healthy volunteers,and comparison of their evaluation of glomerular filtration function in chronic renal patients[J].Chin J Lab Med,2006,29(11):970-974.
[5] 王 艳,宋文琪,任 娜,等.北京地区儿童肾功能生化项目参考区间调查[J].现代检验医学杂志,2013,28(6):26-28,31. Wang Y,Song WQ,Ren N,et al.Investigation of reference intervalsof kidney clinical biochemistry tests for healthy children in Beijing[J].Journal of Modern Laboratory Medicine,2013,28(6):26-28,31.
[6] 张兴锋,徐文波,代艳娟,等.玉溪市儿童血清半胱氨酸蛋白酶抑制剂C参考区间的建立[J].检验医学,2014,29(10):1049-1052. Zhang XF,Xu WB,Dai YJ,et al.The establishment of reference interval of serum Cystatin C of children in Yuxi City[J].Lab Med,2014,29(10):1049-1052.
[7] Heiduk M,P(¨overa)ge I,Kliem C,et al.Pediatric reference intervalsdetermined in ambulatory and hospitalized children and juveniles[J].Clin Chim Acta,2009,406(1/2):156-161.
[8] 张志明,张蓬杰.血肌酐、胱抑素C、简化MDRD和Le Bricon公式在评估肾移植术后肾功能中的作用[J].现代检验医学杂志,2014,29(5):97-99,103. Zhang ZM,Zhang PJ.Role of serum creatinine,Cystatin C,Abbreviated MDRD and Le Bricon formula in the evaluation of renal function after renal transplantation[J].Journal of Modern Laboratory Medicine,2014,29(5):97-99,103.
[9] 武冬娜,张文杰,唐招平,等.血清Cys C和24 h尿微量清蛋白定量联合检测对妊娠期糖尿病肾病的早期诊断价值[J].现代检验医学杂志,2015,30(2):139-141. Wu DN,Zhang WJ,Tang ZP,et al.Diagnostic value of combined measuring of serum Cystatin C and 24h urine microalbumin in early gestational diabeteskidney disease[J].Journal of Modern Laboratory Medicine,2015,30(2):139-141.
[10] Levey AS,Coresh J,Greene T,et al.Using standardized serum creatinine values in the modification of diet in renal disease study equation forestimating glomerular filtration rate[J].Ann Intern Med,2006,145(4):247-254.

相似文献/References:

[1]蔡加炉,王 成,汪俊军.循环微小核糖核酸与2型糖尿病的关系[J].现代检验医学杂志,2015,30(03):5.[doi:10.3969/j.issn.1671-7414.2015.03.002]
 CAI Jia-lu,WANG Cheng,WANG Jun-jun.Relationship between Circulating miRNA and Type 2 Diabetes[J].Journal of Modern Laboratory Medicine,2015,30(04):5.[doi:10.3969/j.issn.1671-7414.2015.03.002]
[2]唐海霞,王 成,路美玲,等.肾透明细胞癌患者血清miR-193a-3p水平增加及早期诊断价值[J].现代检验医学杂志,2015,30(03):43.[doi:10.3969/j.issn.1671-7414.2015.03.012]
 TANG Hai-xia,WANG Cheng,LU Mei-ling,et al.Elevated Serum miR-193a-3p Level in Renal Clear Cell Carcinoma and Its Early Clinical Value[J].Journal of Modern Laboratory Medicine,2015,30(04):43.[doi:10.3969/j.issn.1671-7414.2015.03.012]
[3]万淑君,王 成,王 静,等.2型糖尿病微血管并发症患者血清miR-16,miR-126和miR-221水平检测及临床意义[J].现代检验医学杂志,2016,31(05):9.[doi:10.3969/j.issn.1671-7414.2016.05.003]
 WAN Shu-jun,WANG Cheng,WANG Jing,et al.Study on Serum Levels of miR-16,miR-126 and miR-221 and Their Clinical Significance in Type 2 Diabetes Patients with or Without Microvascular Complications[J].Journal of Modern Laboratory Medicine,2016,31(04):9.[doi:10.3969/j.issn.1671-7414.2016.05.003]
[4]朱卫华,刘继斌,林兰.胃癌相关甲基化分型与幽门螺杆菌感染的探讨[J].现代检验医学杂志,2016,31(06):55.[doi:10.3969/j.issn.1671-7414.2016.06.015]
 ZHU Wei-hua,LIU Ji-bin,LIN Lan.Relationship between the CpG Island Methylator Phenotype and Helicobacter Pylori Infection Associated with Gastric Cancer[J].Journal of Modern Laboratory Medicine,2016,31(04):55.[doi:10.3969/j.issn.1671-7414.2016.06.015]
[5]李兵,傅尧,符义富,等.IL-17F在口腔鳞状细胞癌患者血清中的表达及意义[J].现代检验医学杂志,2016,31(06):77.[doi:10.3969/j.issn.1671-7414.2016.06.021]
 LI Bing,FU Yao,FU Yi-fu,et al.Expression of Interleukin 17F in Serum of Oral Squamous Cell Carcinoma Patients and Its Clinic Significance[J].Journal of Modern Laboratory Medicine,2016,31(04):77.[doi:10.3969/j.issn.1671-7414.2016.06.021]
[6]卜晓敏,宋佳希,樊春荔,等.颅脑损伤患者血清αⅡ血影蛋白裂解产物(SBDPs)水平检测的临床意义[J].现代检验医学杂志,2017,32(01):9.[doi:10.3969/j.issn.1671-7414.2017.01.003]
 BU Xiao-min,SONG Jia-xi,FAN Chun-li,et al.Study on Serum Levels of SBDPs and Their Clinical Significance in Patients with Traumatic Brain Injury[J].Journal of Modern Laboratory Medicine,2017,32(04):9.[doi:10.3969/j.issn.1671-7414.2017.01.003]
[7]李 兵a,傅 尧a,符义富a,等.口腔鳞状细胞癌患者血清中CCL2和VEGF表达的初步研究[J].现代检验医学杂志,2017,32(04):64.[doi:10.3969/j.issn.1671-7414.2017.04.018]
 LI Binga,FU Yaoa,FU Yi-fua,et al.Preliminary Study on the Expression of CCL2 and VEGF in Serum of Patients with Oral Squamous Cell Carcinoma[J].Journal of Modern Laboratory Medicine,2017,32(04):64.[doi:10.3969/j.issn.1671-7414.2017.04.018]
[8]黄钰君,伍绍国,丘媛媛,等.广州地区正常儿童血清叶酸参考区间调查[J].现代检验医学杂志,2017,32(04):125.[doi:10.3969/j.issn.1671-7414.2017.04.036]
 HUANG Yu-jun,WU Shao-guo,QIU Yuan-yuan,et al.Investigation of the Normal Reference Range for Serum Folate of Healthy Children in Guangzhou Region[J].Journal of Modern Laboratory Medicine,2017,32(04):125.[doi:10.3969/j.issn.1671-7414.2017.04.036]
[9]武 琪a,陈 亮b,张宝华c.帕金森病患者血清和脑脊液褪黑素水平变化及其临床意义[J].现代检验医学杂志,2017,32(05):90.[doi:10.3969/j.issn.1671-7414.2017.05.017]
 WU Qia,CHEN Liangb,ZHANG Bao-huac.Changes and Clinical Significance of Melatonin in Blood and Cerebrospinal Fluid of Patients with Parkinson's Disease[J].Journal of Modern Laboratory Medicine,2017,32(04):90.[doi:10.3969/j.issn.1671-7414.2017.05.017]
[10]朱媛媛a,b,罗 阳,等.儿童原发性肾病综合征患者血清miR-150水平变化及其临床意义[J].现代检验医学杂志,2017,32(06):6.[doi:10.3969/j.issn.1671-7414.2017.06.001]
 ZHU Yuan-yuana,b,LUO Yang,et al.Study on the Levels and Clinical Significance of Serum miR-150 in Children with Nephrotic Syndrome[J].Journal of Modern Laboratory Medicine,2017,32(04):6.[doi:10.3969/j.issn.1671-7414.2017.06.001]

备注/Memo

备注/Memo:

作者简介:黄金文(1975-),男,硕士,副主任技师,主要从事生物化学及分子生物学检验,Tel:18138851543,E-mail:jinwenh567@sina.com.cn。
更新日期/Last Update: 2016-08-10