[1]胡森安a,艾红红b,严丽花a,等.维生素D及日照量对单纯性肥胖儿童血清瘦素水平影响的研究[J].现代检验医学杂志,2016,31(06):143-146.[doi:10.3969/j.issn.1671-7414.2016.06.043]
　HU Sen-ana,AI Hong-hongb,YAN Li-huaa,et al.Effect of Vitamin D and Sunlight on Serum Leptin Levels in Simple Obese Children[J].Journal of Modern Laboratory Medicine,2016,31(06):143-146.[doi:10.3969/j.issn.1671-7414.2016.06.043]
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维生素D及日照量对单纯性肥胖儿童血清瘦素水平影响的研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年06期
页码:
143-146
栏目:
检验与临床
出版日期:
2016-12-20

文章信息/Info

Title:
Effect of Vitamin D and Sunlight on Serum Leptin Levels in Simple Obese Children
作者:
胡森安a; 艾红红b; 严丽花a; 钟剑文a
佛山市高明区人民医院a.检验科; b.儿科,广东佛山 528500
Author(s):
HU Sen-ana; AI Hong-hongb; YAN Li-huaa; ZHONG Jian- wena
a.Department of Clinical Laboratory, b.Department of Paediatrics Foshan City People's Hospital,GuangdongFoshan 528500,China
关键词:
维生素D;  日照量;  单纯性肥胖儿童;  瘦素
分类号:
R723.14; R446.11
DOI:
10.3969/j.issn.1671-7414.2016.06.043
文献标志码:
A
摘要:
目的 探究规范剂量补充维生素D(VitD)和适度日照对单纯性肥胖儿童血清瘦素水平的影响。方法 收集单纯性肥胖儿童150例和正常健康儿童50例,按自愿原则将150例单纯性肥胖儿童随机分为3组,每组50例,其中一组单纯的合理膳食和保持适量运动,另一组在合理膳食和保持适量运动的前提下,接受每天补充维生素D3制剂700IU,持续6个月,称为添加VitD组,第三组在合理膳食,适量运动的前提下,不人为添加VitD,但是必须坚持每周日照时间不少于10 h,跟踪6个月。运用高效液相色谱法和ELISA法检查所有受试者治疗前后血液中25羟基VitD[25(OH)D]含量和血清瘦素(Leptin)水平。结果 治疗后25(OH)D含量比较:添加VitD组(77.1±14.7 nmol/L)和日照组(75.2±12.8 nmol/L)均显著高于未添加VitD组(52.3±15.2nmol/L)(均P<0.01),而添加VitD组与日照组比较差异无统计学意义(P>0.05); 治疗后血清瘦素水平比较:添加VitD组(12.38±2.56 μg/L)和日照组(12.45±2.67 μg/L)均显著高于未添加VitD组(15.34±2.31 μg/L)(均P<0.01),添加VitD组与日照组比较差异无统计学意义(P>0.05)。结论 在合理膳食和适量运动的前提下,规范补充维生素D和适度日照量能降低单纯性肥胖儿童瘦素水平,提高血液25(OH)D含量,对防治儿童单纯性肥胖有积极意义。
Abstract:
Objective To explore the effect of the standarddose of vitamin D supplementation and moderate sunshine on the serum leptin levels in simple obese children.Methods 150 cases of simpleobesity children and 50 healthy children were collected,and 150 cases of simple obesity were randomly divided into 3 groups according to the voluntary principle,50 cases in each group,one single set of reasonable diet and regular exercise,another group in a reasonable diet and maintain appropriate amount of exercise under the premise,take vitamin D3 supplements every day 700IU,continued for 6 months,said to add vitamin D group,the third group in a reasonable diet,moderate exercise under the premise,not artificially add vitamin D,but must adhere to weekly sunshine duration of not less than 10 hours and 6 months follow-up.Method was used to examine the content of 25(OH)D and serum leptin in bloodof all subjects before and after treatment with HPLC and ELISA method.Results After treatment,25(OH)D content:add VitD group(77.1±14.7 nmol/L)and sunshine group (75.2±12.8 nmol/L)were significantly higher than the control group without VitD (52.3±15.2 nmol/L)(P<0.01),and compared with the addition of sunshine was no significant difference in VitD group(P>0.05).Comparison of leptin level after treatment,blood group:add VitD(12.38±2.56 μg/L)and sunshine group(12.45±2.67 μg/L)were significantly higher than the control group without VitD(15.34±2.31 μg/L) (P<0.01),add the VitD group compared with the group without significant difference (P>0.05).Conclusion Under the premise of reasonable diet and regular exercise,specification of vitamin D and moderate sunshine amount can reduce the simple besity children leptin levels,improve blood 25(OH)D content,on the prevention and treatment of children with simple obesity havepositive significance.

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备注/Memo

备注/Memo:
作者简介:胡森安(1984-),男,本科,主管技师,研究方向为免疫学检验,E-mail:ansenhu@126.com。
更新日期/Last Update: 2016-12-20