[1]顾进a,侯思南a,许海英b.中性粒细胞淋巴细胞比率在衡量肥胖病人炎症状态的初步探讨[J].现代检验医学杂志,2016,31(06):147-149.[doi:10.3969/j.issn.1671-7414.2016.06.044]
　GU Jina,HOU Si-nana,XU Hai-yingb.Preliminary Study on Neutrophil-Lymphocyte Ratio as an Indicator of Inflammatory State in Obese Patients[J].Journal of Modern Laboratory Medicine,2016,31(06):147-149.[doi:10.3969/j.issn.1671-7414.2016.06.044]
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中性粒细胞淋巴细胞比率在衡量肥胖病人炎症状态的初步探讨()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年06期
页码:
147-149
栏目:
检验与临床
出版日期:
2016-12-20

文章信息/Info

Title:
Preliminary Study on Neutrophil-Lymphocyte Ratio as an Indicator of Inflammatory State in Obese Patients
作者:
顾进a; 侯思南a; 许海英b
连云港市中医院 a.检验科; b.体检中心, 江苏连云港 222004
Author(s):
GU Jina; HOU Si-nana; XU Hai-yingb
a.Department of Laboratory Medicine; b.Medical Examination Center, Lianyungang Traditional Hospital,Jiangsu Lianyungang 222004,China
关键词:
中性粒细胞淋巴细胞比率;  肥胖;  炎症
分类号:
R446.111; R589.2
DOI:
10.3969/j.issn.1671-7414.2016.06.044
文献标志码:
A
摘要:
目的 观察中性粒细胞淋巴细胞比率(neutrophil-lymphocyte ratio,NLR)作为炎症标志物在患有肥 胖和代谢综合征的病人中的诊断价值。方法 根据肥胖程度和代谢综合征的发展状态选取253个受试对象,根 据WHO推荐诊断标准,BMI<25 kg/m2,25 kg/m2<BMI<30 kg/m2,BMI>30分别为健康组、超重组和肥胖组,比较各组间的代谢和炎症标志物,并进行相 关分析。结果 各组间白细胞计数和C反应蛋白(CRP)有显著差异(P<0.01),随着肥胖程度的发展, 淋巴细胞和中性粒细胞计数显著增加,NLR在各组间无显著性差异(P<0.05)。白细胞总数、中性 粒细胞、淋巴细胞和CRP与身高体重指数(BMI)呈显著相关性,但是NLR和BMI无显著相关性。结论 对评价肥 胖伴代谢综合征病人的炎症状态,NLR不是一个好的衡量炎症指标,白细胞计数和CRP是比较有用的衡量炎症 指标。
Abstract:
Objective To investigate the usage of the neutrophil-lymphocyte ratio(NLR)as an inflammatory marker in obese patients withand without metabolic syndrome(MetS).Methods Individuals whose BMI was >30 and 25kg/m2 were accepted as obese and overweight according to WHO recommendations.253 subjects were selected according to degree of obesity and status of Mets and assigned groups as obese overweight and control group respectively.Metabolic and inflammatory markers were compared between groupsand correlation analysis was performed.Results Leukocytecount and CRP were significantly different(P<0.001) between groups,bothlymphocyte and neutrophil counts were significantly increased with increased degree of obesity(P<0.05),but NLR was not different between body mass index(BMI)groups(P=0.228).Leukocyte,neutrophil,and lymphocyte counts and CRP level showed a significant correlation with BMI(P<0.001),whereas NLR was not correlated with BMI(P=0.667).Conclusion NLRwould not be a good indicator of inflammation while leukocyte count and CRP aremore useful biomarkers to indicate inflammation in obese patients with and without MetS.

参考文献/References:

[1] Farooq W,Farwa U,Khan F.The metabolic syndro-me and inflammation:role of insulin resistance and increased adiposity[J].Oman Med J,2015,30(2):100-103.
[2] Brooks GC,Blaha MJ,Blumenthal RS.Relation of C-reactive protein to abdominal adiposity [J].Am J Cardiol,2010,106(1):56-61.
[3] Casula M,Tragni E,Zambon A,et al.C-reactive protein distribution andcorrelation with traditional cardiovascular risk factors in the Italian population[J].Eur J Intern Med,2013,24(2):161-166.

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备注/Memo

备注/Memo:
作者简介:顾 进(1972-),女,学士,主任技师,研究方向:临床检验学,E -mail:lyggujin1971@163.com。
更新日期/Last Update: 2016-12-20