[1]董兵卫,李文生,马晓燕,等.肾原发性黏膜相关淋巴组织淋巴瘤一例临床病理特征及文献回顾[J].现代检验医学杂志,2017,32(01):121-123,127.[doi:10.3969/j.issn.1671-7414.2017.01.033]
　DONG Bing-wei,LI Wen-sheng,MA Xiao-yan,et al.Clinicopathological Characteristics of Primary Renal Mucosa Associated Lymphoid Tissue Lymphoma:A Case Report and Review Literature[J].Journal of Modern Laboratory Medicine,2017,32(01):121-123,127.[doi:10.3969/j.issn.1671-7414.2017.01.033]
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肾原发性黏膜相关淋巴组织淋巴瘤一例临床病理特征及文献回顾()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年01期
页码:
121-123,127
栏目:
研究简报·实验技术
出版日期:
2017-01-25

文章信息/Info

Title:
Clinicopathological Characteristics of Primary Renal Mucosa Associated Lymphoid Tissue Lymphoma:A Case Report and Review Literature
文章编号:
1671-7414(2017)01-121-04
作者:
董兵卫1; 李文生2; 马晓燕1; 石艳宏1; 朱西宁1
1.咸阳市中心医院病理科,陕西咸阳 712000;
2.陕西省人民医院病理科,西安710068
Author(s):
DONG Bing-wei1; LI Wen-sheng2; MA Xiao-yan1; SHI Yan-hong1; ZHU Xi-ning1
1.Department of Pathology,Xianyang Centre Hospital,Shaanxi Xianyang 712000,China;
2.Department of Pathology,Shaanxi Provincial People's Hospital,Xi'an710068,China
关键词:
肾;  黏膜相关淋巴组织淋巴瘤;  临床病理
分类号:
R733; R446.8
DOI:
10.3969/j.issn.1671-7414.2017.01.033
文献标志码:
A
摘要:
目的 肾原发性黏膜相关淋巴组织淋巴瘤(MALT淋巴瘤)罕见,该文探讨肾原发性MALT淋巴瘤的临床病理特征、诊断和鉴别诊断。方法 对1例肾原发性MALT淋巴瘤进行临床检查、病理组织形态学观察及免疫组化染色,并复习相关文献。结果 肾原发性MALT淋巴瘤临床与影像学检查结果缺乏特征性表现,组织学显示淋巴细胞弥漫性浸润,瘤细胞形态呈中心细胞样、单核细胞样,并可见浆细胞样细胞,显示淋巴上皮病变和滤泡植入现象,免疫组化染色结果显示:阳性染色结果:CD20+,PAX-5+,CD79α+,MUM-1+,阴性染色结果:CD3,CD5,CD45RO,bcl-2,CD10,bcl-6,CyclinD1; CD21显示破损的FDC网,kappa+,Lambda-,呈单克隆表型,Ki-67增殖指数约35%。病理诊断:肾原发性MALT淋巴瘤。结论 肾原发性MALT淋巴瘤罕见,因缺乏特异性临床表现及影像学依据而极易误诊,明确诊断依赖病理学检查,免疫组化染色有助于鉴别诊断。
Abstract:
Objective Primary renal mucosa associated lymphoid tissue lymphoma(MALT lymphoma)is very rare,here discuss the clinical pathological characteristics and diagnosis,differential diagnosis of primary renal MALT lymphoma.Methods A case of primary renal MALT lymphoma was assayed for clinical and histopathological morphology,an well as immunohistochemical staining,then reviewed the relevant literature.ResultsThe clinical and imaging characteristics of renal lymphoma lack ofspecific performance,the tissue section of the kidney biopsy showed diffuse infiltration of small lymphocytes.The small lymphocytes were centrocytes-like,monocytes-like,and plasma cell differentiation was recognized.Lymphoepithelial lesions were scattered.Follicular implanted phenomenon could been seen.Immunohistochemically result:the tumor cells were positive for CD20,PAX-5,CD79α and MUM-1,but negative for CD3,CD5,CD45RO,bcl-2,CD10,bcl-6 and CyclinD1.CD21 showed damage FDC network,positive for Kappa,negative for lambda,and it showed monoclonal phenotype,the Ki-67 index was about 35%.Final pathology diagnosis was primary renal MALT lymphoma.Conclusion Primary renal MALT lymphoma is very rare,the clinical manifestations and imaging characteristic of renal lymphoma are non-specific and misdiagnosis frequently occurs in clinical practice,definite diagnosis depends on pathological examination,immunohistochemical staining is helpful to differential diagnosis.

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备注/Memo

备注/Memo:
作者简介:董兵卫(1971-),男,硕士,副主任医师,陕西省病理学会常委,咸阳病理学会副主任委员,专业方向:软组织肿瘤及淋巴组织病变诊断,E-mail:rxrfdbw@126.com。
更新日期/Last Update: 2017-01-20