[1]程晓静,邢 准a,王秋实b,等.围手术期患者血栓弹力图参数与血小板计数相关性分析[J].现代检验医学杂志,2018,33(02):121-124.[doi:10.3969/j.issn.1671-7414.2018.02.001]
　CHENG Xiao-jing,XING Zhuna,WANG Qiu-shib,et al.Investigation of Correlation between Parameters of Thrombelastogram and Platelet Count in Perioperative Patients[J].Journal of Modern Laboratory Medicine,2018,33(02):121-124.[doi:10.3969/j.issn.1671-7414.2018.02.001]
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围手术期患者血栓弹力图参数与血小板计数相关性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年02期
页码:
121-124
栏目:
检验与临床
出版日期:
2018-04-05

文章信息/Info

Title:
Investigation of Correlation between Parameters of Thrombelastogram and Platelet Count in Perioperative Patients
文章编号:
1671-7414(2018)02-121-04
作者:
程晓静1; 邢 准2a; 王秋实2b; 何燕京2b
1.辽宁省阜新市中心血站,辽宁阜新 123000; 2.中国医科大学附属盛京医院a.麻醉科; b.输血科,沈阳 110004
Author(s):
CHENG Xiao-jing1; XING Zhun2a; WANG Qiu-shi2b; HE Yan-jing2b
1.Fuxin Center Blood Station, Laoning Fuxin 123000,China; 2a.Department of Aneathesiology; 2b.Department of Blood Transfusion,Shengjing Hospital of China Medical University,Shenyang 110004,China
关键词:
血栓弹力图;  血小板;  凝血功能;  相关性
分类号:
R446.11
DOI:
10.3969/j.issn.1671-7414.2018.02.001
文献标志码:
A
摘要:
目的 探讨围手术期患者不同水平血小板(PLT)与血栓弹力图(TEG)参数和常规凝血检测参数的相关性。方法 选取2012年1月～2014年5月期间围手术期PLT减少症患者69例,PLT正常患者35例和PLT增高患者35例。分析其TEG参数[包括凝血反应时间(R),血细胞凝集成块时间(K),血细胞凝集成块速率(Angle),凝血块的最大强度(MA)]与常规凝血检测参数[包括凝血酶原时间(PT),活化部分凝血酶时间(APTT)和PLT计数]的相关性,以及不同水平PLT的患者PLT计数与上述指标的相关性。结果 与PLT计数呈正相关的TEG参数有:MA(r=0.57,P<0.000 1),Angle(r=0.54,P<0.000 1),CI(r=0.57,P<0.0001); R与PLT计数呈负相关(r=-0.27,P<0.000 1)。PLT计数与PT,APTT值无相关性。PLT轻度缺乏组[(87.34±10.43)×109/L]和正常组[(198.47±45.30)×109/L]PLT计数与MA(r=0.48,0.61,均P<0.01)和Angle呈正相关(r=0.53,0.51,均P<0.01),PLT重度降低组[(39.33±10.63)×109/L]和升高组[(330.34±35.43)×109/L]PLT计数与MA(r=0.26,0.15,均P>0.05)和Angle(r=0.20,0.24,均P>0.05)无相关性。结论 正常和轻度PLT降低患者PLT计数与CI,Angle和MA呈显著正相关,与PT,APTT值无相关性; 但在PLT中重度降低和PLT升高患者中,PLT计数与以上参数不相关,PLT中重度降低或者升高患者中PLT计数不能反应其聚集功能,MA更能敏感反应PLT功能。
Abstract:
Abstract:Objective To investigate thrombelastogram(TEG)correlation between parameters and platelet count in perioperative period patients.Methods Selected 139 patients,69 cases with thrombocytopenia,35 cases with normal platelet number and 35 cases with thrombocytosis from 2012 January to 2014 May,monitored TEG,blood coagulation function andthe change of blood routine during perioperative period.Spearman test was usedto analyze the different level of platelet count and other coagulation parameters.Results The positive correlation between platelet count and TEG parameters were:MA(r=0.57,P<0.57),Angle(r=0.54,P<0.000 1),CI(r=0.57,P<0.000 1),and R was negatively correlated with platelet count(r=-0.27,P<0.000 1).There was no significant correlation between PT,APTT and platelet count.In mild lack of platelet group [(87.34±10.43)×109/L] and normal group [(198.47±45.30)×109/L],platelet count was positively correlated with MA and Angle.In severe lower [(39.33±10.63)×109/L] and higher group [(330.34±35.43)×109/L],there was no correlation between platelet platelet count with MA or Angle.Conclusion Platelet count was significantly correlated with CI,Angle and MA,butin patients with moderately severe lower platelet and platelet increase the platelet count do not reflect the aggregation function,MA is more sensitive response to platelet function.

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备注/Memo

备注/Memo:
基金项目:辽宁省省直医院重点临床科室诊疗能力建设项目(LNCCC-D13-2015)。 作者简介:程晓静(1973-),女,本科,副主任医师,主要研究方向:输血安全,E-mail:fxxzcxj@126.com。 通讯作者:邢 准(1973-),男,硕士研究生,副教授,副主任医师,主要研究方向:围手术期患者血液管理,E-mail:xingzhun@126.com。
更新日期/Last Update: 2018-04-16