[1]赵慧茹a,王 聪b,苏 玉a,等.关节置换围术期患者血浆内皮细胞蛋白C受体和血栓调节蛋白水平变化分析[J].现代检验医学杂志,2018,33(02):125-126,133.[doi:10.3969/j.issn.1671-7414.2018.02.001]
　ZHAO Hui-rua,WANG Congb,SU Yua,et al.Analysis of Changes in Plasma Endothelial Protein C Receptor and Thrombomodulin Level in Patients with Joint Replacement During Perioperative Period[J].Journal of Modern Laboratory Medicine,2018,33(02):125-126,133.[doi:10.3969/j.issn.1671-7414.2018.02.001]
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关节置换围术期患者血浆内皮细胞蛋白C受体和血栓调节蛋白水平变化分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年02期
页码:
125-126,133
栏目:
检验与临床
出版日期:
2018-04-05

文章信息/Info

Title:
Analysis of Changes in Plasma Endothelial Protein C Receptor and Thrombomodulin Level in Patients with Joint Replacement During Perioperative Period
文章编号:
1671-7414(2018)02-125-03
作者:
赵慧茹a; 王 聪b; 苏 玉a; 张会英a
北京积水潭医院a.检验科; b.急诊科,北京 100035
Author(s):
ZHAO Hui-rua; WANG Congb; SU Yua; ZHANG Hui-yinga
a.Department of Clinical Laboratory; b.Department of Emergency,Beijing Jishuitan Hospital,Beijing 100035,China
关键词:
内皮细胞蛋白C受体;  血栓调节蛋白;  关节置换术
分类号:
R687.4; R392.11
DOI:
10.3969/j.issn.1671-7414.2018.02.001
文献标志码:
A
摘要:
目的 评估血浆内皮细胞蛋白C受体(endothelial cell protein C receptor,EPCR)和血栓调节蛋白(thrombomodulin,TM)在人工关节置换术围术期的水平变化。方法 119例(男32例,女87例,年龄57.75±12.04岁)于2015年3～6月间在北京积水潭医院矫形骨科接受全膝关节置换术和全髋关节置换术的患者,观察其在术前、术后第1天和第3天血浆内皮细胞EPCR和TM的浓度变化。结果 ①血浆EPCR浓度术后第1天与术前相比减低40.34%,术后第3天与术前相比减低49.45%,术后第3天与术后第1天相比减低15.26%,差异均具有统计学意义(F=5.63,均P<0.05); ②血浆TM浓度术后第1天与术前相比减低12.77%,术后第3天与术前相比减低40.53%,术后第3天与术后第1天相比减低31.83%,差异均具有统计学意义(F=7.87,均P<0.05)。结论 关节置换术后3天内EPCR和TM水平进行性减低。
Abstract:
Abstract:Objective To evaluate the level of plasma endothelial cell protein C receptor(EPCR)and thrombomodulin(TM)in the perioperative period of artificial joint replacement.Methods 119 patients(male 32,female 87,age distribution 57.75±12.04)who underwent totalknee replacement and total hip arthroplasty from March to June 2015 in Department of Orthopedics of Beijing Jishuitan Hospital were selected.The levels of plasma endothelial cell EPCR and TM were compared before and after operation for 1and 3 days.Results ①The concentration of plasma EPCR onthe first day after surgery was reduced by 40.34% compared with preoperative,and on the third day after surgery reduced by 49.45% compared with preoperative,and on the third day after surgery was reduced by 15.26% compared with the first day after surgery.The differences were all statistically significant(F=5.63,P<0.05).②The concentration of plasma TM on the first day after surgery was reduced by 12.77% compared with preoperative,and on the third day after surgery reduced by 40.53% compared with preoperative,and on the third dayafter surgery was reduced by 31.83% compared with the first day after surgery.The differences were all statistically significant(F=7.87,P<0.05).Conclusion The concentration of EPCR and TM were progressivelyreduced within 3 days after arthroplasty.

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备注/Memo

备注/Memo:
作者简介:赵慧茹(1979-),女,硕士,主治医师,研究方向:出凝血疾病的实验室诊断及骨髓细胞形态学,E-mail:zhrjst@163.com。 通讯作者:张会英,E-mail:zhy_0825@hotmail.com。
更新日期/Last Update: 2018-04-16