[1]靳庆娥,乌姗娜,张亚鑫,等.血清糖化血红蛋白和CA15-3水平检测与女性乳腺癌发病风险的相关性研究[J].现代检验医学杂志,2019,34(04):143-145.[doi:10.3969/j.issn.1671-7414.2019.04.035]
　JIN Qing-e,WU Shan-na,ZHANG Ya-xin,et al.Relationship of Glycosylated Hemoglobin A1c and Tumor Marker CA15-3 Levels in Serum with Breast Cancer Susceptibility in Women of Beijing Area[J].Journal of Modern Laboratory Medicine,2019,34(04):143-145.[doi:10.3969/j.issn.1671-7414.2019.04.035]
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血清糖化血红蛋白和CA15-3水平检测与女性乳腺癌发病风险的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年04期
页码:
143-145
栏目:
检验与临床
出版日期:
2019-08-20

文章信息/Info

Title:
Relationship of Glycosylated Hemoglobin A1c and Tumor Marker CA15-3 Levels in Serum with Breast Cancer Susceptibility in Women of Beijing Area
文章编号:
1671-7414(2019)04-143-03
作者:
靳庆娥; 乌姗娜; 张亚鑫; 苏建荣
(首都医科大学附属北京友谊医院检验科,北京 100050)
Author(s):
JIN Qing-e; WU Shan-na; ZHANG Ya-xin; SU Jian-rong
(Department of Clinical Laboratory,Beijing Friendship Hospital of the Second Clinical Medical College of Capital Medical University,Beijing100050,China)
关键词:
糖化血红蛋白;  糖蛋白抗原15-3;  乳腺癌;  易感性
分类号:
R737.9; R730.43
DOI:
10.3969/j.issn.1671-7414.2019.04.035
文献标志码:
A
摘要:
目的 探讨糖化血红蛋白和糖蛋白抗原15-3(CA15-3)水平与女性乳腺癌发病风险的关系。方法 收集2016～2018年107例确诊为乳腺癌的女性患者,选取年龄相匹配的110例女性体检者为对照组,采用高效液相色谱法和化学发光法检测血清中HbA1c和CA15-3的水平,非条件Logistic回归分析其与乳腺癌的相关性。结果 乳腺癌组HbA1c 和CA15-3异常率分别为30.84%(33/107)和8.41%(9/107),对照组HbA1c和CA15-3异常率分别为23.64%(26/110)和2.73%(3/110),差异均有统计学意义(t=2.830,P=0.005; t=3.349,P=0.001)。回归分析显示,HbA1c和CA15-3异常患者发生乳腺癌的风险都显著升高(OR=1.332,95%CI=1.016～1.745; OR=1.047,95%CI=1.008～1.088)。结论 高水平HbA1c和CA15-3是女性乳腺癌发生的危险因素。
Abstract:
Objective To evaluate the association of HbA1cand CA15-3 levels with breast cancer risk in women of China.Methods A case-control study was performed with 107 breast cancer patients and 110 age-matched check-up controls collected from 2016 to 2018.The serumlevels of HbA1c and CA15-3 were measured by high performance liquid chromatography assay and chemiluminescence method respectively.Logistic regression analyses were performed to examine the relationship.Odds ratios(OR)and 95% confidence intervals(CI)were estimated.Results The prevalenceof HbA1c and CA15-3 in case group were 30.84%(33/107)and 8.41%(9/107),whereas the unusual rates of which were 23.64%(26/110)and 2.73%(3/110)respectively in the control group.The results were significantly different(t=2.830,P=0.005; t=3.349,P=0.001).Elevated HbA1c and CA15-3 levels were significantly associated with increased breast carcinoma risk compared with the control group(OR=1.332,95%CI=1.016～1.745; OR=1.047,95%CI=1.008～1.088).Conclusion High levels of HbA1c and CA15-3 would be risk factors for female breast cancer.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:靳庆娥(1981-),女,博士,助理研究员,主要从事病原体分子诊断工作,E-mail:jinqinge@163.com。 通讯作者:苏建荣,女,主任医师,博士生导师,主要从事感染性疾病诊断及病原微生物耐药机制研究,E-mail:youyilab@163.com。收稿日期:2019-02-15 修回日期:2019-04-17
更新日期/Last Update: 2019-07-30