[1]刘 娜,尤建萍,王 博,等.妊娠晚期孕妇阴道B族链球菌感染青霉素钠治疗对血浆凝血功能及新生儿结局的影响分析[J].现代检验医学杂志,2019,34(04):146-150.[doi:10.3969/j.issn.1671-7414.2019.04.036]
　LIU Na,YOU Jian-ping,WANG Bo,et al.Analysis on the Influences of Penicillin Sodium Treatment on Plasma Coagulation Functions and Neonatal Outcomes in Late Pregnant Women with Vaginal Group B Streptococcus Infections[J].Journal of Modern Laboratory Medicine,2019,34(04):146-150.[doi:10.3969/j.issn.1671-7414.2019.04.036]
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妊娠晚期孕妇阴道B族链球菌感染青霉素钠治疗对血浆凝血功能及新生儿结局的影响分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年04期
页码:
146-150
栏目:
检验与临床
出版日期:
2019-08-20

文章信息/Info

Title:
Analysis on the Influences of Penicillin Sodium Treatment on Plasma Coagulation Functions and Neonatal Outcomes in Late Pregnant Women with Vaginal Group B Streptococcus Infections
文章编号:
1671-7414(2019)04-146-05
作者:
刘 娜1; 尤建萍1; 王 博1; 韩 珊1; 唐 杰1; 董乔乔1; 张凤霞2; 孟帅磊2
(1.西安安琪儿妇产医院检验科,西安 710065; 2.郑州金域临床检验中心,郑州 450000)
Author(s):
LIU Na1; YOU Jian-ping1; WANG Bo1; HAN Shan1; TANG Jie1; DONG Qiao-qiao1;  ZHANG Feng-xia2; MENG Shuai-lei2
(1.Department of Clinical Laboratory, Xi'an Angel's Obstetrics and Gynecology Hospital,Xi'an 710065,China; 2.Zhengzhou Jinyu Clinical Laboratory Center,Zhengzhou 450000,China)
关键词:
青霉素钠;  妊娠晚期;  B族链球菌;  凝血功能;  新生儿结局
分类号:
R378.12; R722.13
DOI:
10.3969/j.issn.1671-7414.2019.04.036
文献标志码:
A
摘要:
目的 分析青霉素钠对妊娠晚期B族链球菌(GBS)感染孕妇凝血功能及新生儿结局的影响。方法 选取西安安琪儿妇产医院2016年2月～2018年12月收治的64例妊娠晚期GBS感染孕妇作为研究对象,应用随机数字表法将其分为研究组和对照组,每组32例。对照组不给予预防性应用抗生素,研究组于确诊GBS感染时及临产时给予静脉滴注青霉素钠治疗。于给予抗生素前和分娩次日采集两组研究对象的外周血样本,对凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、国际标准化比率(INR)和纤维蛋白原(FIB)水平进行检测和比较; 对两组新生儿不良妊娠结局的发生率进行观察和对比。结果 研究组治疗后的PT和ATPP分别为12.24±1.65 s和28.26±4.56s,长于对照组的9.52±1.53 s和26.13±3.81 s,INR研究组为1.08±0.07,高于对照组的0.98±0.05,FIB研究组为2.61±0.43 g/L,低于对照组的3.89±1.71 g/L,差异均有统计学意义(t=6.838,4.107,6.576和2.028,P=0.000,0.000,0.000和0.047)。两组新生儿均未见GBS感染病例,研究组新生儿的不良结局的总发生率6.25%(2/32)低于对照组28.13%(9/32),差异有统计学意义(χ2 =3.952,P=0.047)。结论 针对妊娠晚期GBS感染孕妇在确诊时和临产时应用青霉素钠进行预防性抗感染治疗,能够改善孕产妇机体的凝血功能指标,缓解其血液高凝状态,改善新生儿不良妊娠结局。
Abstract:
Objective To analyze the effect of penicillin sodium on coagulation function and neonatal outcomes of pregnant women with groupB Streptococcus(GBS)infection in the third trimester of pregnancy.Methods 64 pregnant women with GBS infection in the third trimester of pregnancy in Xi'an Angel Children's Maternity Hospital from February2016 to December 2018 were selected as the study subjects.They were divided into study group and control group with 32 cases in each group by random number table method.The control group was not given prophylactic use of antibiotics,while the study group was given intravenous infusion of penicillin sodium at the time of diagnosis of GBS infection and delivery.The peripheral blood samples of the subjects in the two groups were collected before antibiotics treatment and onthe next day of delivery.The levels of prothrombin time(PT),activated partialthromboplastin time(APTT),thrombin time(TT),international normalized ratio(INR)and fibrinogen(FIB)were detected and compared.The incidences of the adverse pregnancy outcomes such as GBS infection,pathological jaundice,asphyxia and intrauterine distress of the newborns in the two groups were detected and compared.Results After the treatment,PT and ATPP in the studygroup were 12.24±1.65s,and 28.26±4.56s longer than those in the controlgroup 9.52±1.53s and 26.13±3.81s,INR was 1.08±0.07 higher than that inthe control group 0.98±0.05,FIB was 2.61±0.43 g/L lower than that in thecontrol group 3.89±1.71 g/L,with significant differences(t=6.838,4.107,6.576 and 2.028,P=0.000,0.000,0.000 and 0.047).There was no GBS infection in both groups.The total incidence of adverse outcomes in the study group was 6.25%(2/32)lower than 28.13%(9/32)in the control group,the difference was statistically significant(χ2=3.952,P=0.047).Conclusion The application of prophylactic anti-infective therapy with Penicillin Sodium for GBS infected pregnant women in the third trimester ofpregnancy can improve the blood coagulation function of pregnant and lying-in women,alleviate their blood hypercoagulability and reduce the overall incidenceof adverse pregnancy outcomes of newborns to a certain extent.

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相似文献/References:

[1]武爱荣.孕晚期阴道及肛周拭子不同方法检测B族链球菌和真菌的效果评价及耐药分析[J].现代检验医学杂志,2018,33(03):108.[doi:10.3969/j.issn.1671-7414.2018.03.027]
　WU Ai-rong.Effect Evaluation and Drug Resistance Analysis of B Streptococcus and Fungus in Swab of Vaginal and Perianal Detected with Different Methods in Late Pregnancy[J].Journal of Modern Laboratory Medicine,2018,33(04):108.[doi:10.3969/j.issn.1671-7414.2018.03.027]

备注/Memo

备注/Memo:
作者简介:刘 娜(1984-),女,本科,主管检验师,研究方向:临床检验,E-mail:zyy2171@163.com。收稿日期:2019-02-14 修回日期:2019-05-13
更新日期/Last Update: 2019-07-30