[1]王 麟,周朝琼,徐晓华,等.血清肿瘤标志物的参考变化值和参考变化因子应用比较研究[J].现代检验医学杂志,2020,35(01):150-152.[doi:10.3969/j.issn.1671-7414.2020.01.040]
　WANG Lin,ZHOU Chao-qiong,XU Xiao-hua,et al.Comparative Study on the Reference Change Value and Reference Change Factor of Serum Tumor Markers[J].Journal of Modern Laboratory Medicine,2020,35(01):150-152.[doi:10.3969/j.issn.1671-7414.2020.01.040]
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血清肿瘤标志物的参考变化值和参考变化因子应用比较研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年01期
页码:
150-152
栏目:
质量控制·实验室管理
出版日期:
2020-02-29

文章信息/Info

Title:
Comparative Study on the Reference Change Value and Reference Change Factor of Serum Tumor Markers
文章编号:
1671-7414(2020)01-150-03
作者:
王 麟; 周朝琼; 徐晓华; 孔丽蕊
(成都中医药大学附属三院原成都市郫都区中医医院,成都 611730)
Author(s):
WANG Lin;  ZHOU Chao-qiong; XU Xiao-hua;  KONG Li-rui
(the Third Affiliated Hospital of Chengdu University of TCM,the Original Chengdu Pidu District Hospital of TCM, Chengdu 611730,China)
关键词:
肿瘤标志物;  参考变化值;  参考变化因子
分类号:
R730.43
DOI:
10.3969/j.issn.1671-7414.2020.01.040
文献标志码:
A
摘要:
目的 探讨常规肿瘤标志物参考变化值(RCV)和参考变化因子(RCF)单向、双向分别在不同概率下(P<0.05,P<0.01)的应用比较研究。方法 根据参考变化值(RCV)及参考变化因子(RCF)公式计算常规肿瘤标志物在不同概率下的数值。结果 常规肿瘤标志物的RCV(单向,双向在P<0.05时)分别为AFP(30.99%,36.81%),CEA(30.48%,36.21%),CA125(64.30%,76.39%),CA153(15.68%,18.62%),CA199(40.60%,48.23%)和tPSA(43.19%,51.30%)。RCV(单向,双向在P<0.01时)分别为AFP(43.76%,48.45%),CEA(43.05%,47.67%),CA125(90.81%,100.55% ), CA153(22.14%,24.52%),CA199(57.33%,63.48%)和tPSA(60.99%,67.53%)。RCF(单向,双向在P<0.05时)RCFUP-DOWN分别为AFP(1.36%,0.74%,1.44%,0.69%),CEA(1.36%,0.74%,1.44%,0.69%),CA125(1.90%,0.53%,2.15%,0.47%),CA153(1.17%,0.85%,1.2%,0.83%),CA199(1.50%,0.67%,1.62%,0.62%)和tPSA(1.54%,0.65%,1.67%,0.60%)。RCF(单向,双向在P<0.01)RCFUP-DOWN分别为AFP(1.55%,0.65%,1.62%,0.62%),CEA(1.54%,0.65%,1.61%,0.62%),CA125(2.48%,0.40%,2.73%,0.37%),CA153(1.25%,0.80%,1.28%,0.78%),CA199(1.77%,0.56%,1.89%,0.53%)和tPSA(1.84%,0.54%,1.96%,0.51%)。结论 在相同概率下,双侧RCV值高于单侧,而RCF值变化不大。参考变化值RCV仅适用两次检测结果之间的分析,在多于两个连续检测结果时应使用RCF,当RCF作为临床决策工具时可对首诊病人做出正面和负面的预测值,为临床诊断提供科学依据。
Abstract:
Objective To conduct both aunidirectional and bidirectional(P<0.05, P<0.01)comparison between with reference change value(RCV)and reference change factor(RCF)of conventional tumor markers. Methods The values of conventional tumor markers at different probabilities were calculated according to the RCV and RCF formulas.Results The RCV values of six conventional tumor markers(unidirectional and bidirectional at P< 0.05)were calculated as follows: AFP(30.99%, 36.81%),CEA(30.48%,36.21%),CA125(64.30%,76.39%),CA153(15.68%,18.62%),CA199(40.60%,48.23%)and tPSA(43.19%,51.30%),respectively.The RCV values of thesixtumor markers were also calculated(unidirectional and bidirectional at P< 0.01): AFP(43.76%,48.45%),CEA(43.05%,47.67%),CA125(90.81%,100.55% ), CA153(22.14%,24.52%),CA199(57.33%,63.48%)and tPSA(60.99%,67.53%).The RCFUP-DOWN of the six conventional tumor markers(unidirectional and bidirectional at P< 0.05)were calculated as follows: AFP(1.36%,0.74%,1.44%,0.69%),CEA(1.36%,0.74%,1.44%,0.69%),CA125(1.90%,0.53%,2.15%,0.47%),CA153(1.17%,0.85%,1.2%,0.83%),CA199(1.50%,0.67%,1.62%,0.62%)and tPSA(1.54%,0.65%,1.67%,0.60%),respectively.The RCFUP-DOWN of six conventional tumor markers(unidirectional and bidirectional at P<0.01)were AFP(1.55%,0.65%,1.62%,0.62%),CEA(1.54%,0.65%,1.61%,0.62%),CA125(2.48%,0.40%,2.73%,0.37%),CA153(1.25%,0.80%,1.28%,0.78%),CA199(1.77%,0.56%,1.89%,0.53%)and tPSA(1.84%,0.54%,1.96%,0.51%),respectively. Conclusion Under the same probability, the RCV value on both sides was higher than that on one side, while the RCF value changes little. RCV is only applicable to the analysis between two test results, and should be used when there are more than two consecutive test results. When RCF is used as a clinical decision-making tool, positive and negative predictive values can be made for the first patient to provide scientific basis for clinical diagnosis.

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备注/Memo

备注/Memo:
作者简介:王麟(1971-),男,副主任技师,主要从事临检及分子生物学研究,E-mail:820922621@qq.com。 通讯作者:孔丽蕊(1972-),女,本科,学士学位,副主任技师,研究方向:临床生化和免疫学,E-mail:524698472@qq.com。收稿日期:2019-03-26 修回日期:2019-09-19
更新日期/Last Update: 2020-03-30