[1]时小淋a,王晓丰b,刘 鹏a,等.中性粒细胞杀菌机理的最新研究进展[J].现代检验医学杂志,2020,35(01):161-164.[doi:10.3969/j.issn.1671-7414.2020.01.043]
 SHI Xiao-lina,WANG Xiao-fengb,LIU Penga,et al.Recent Research Progress on Germicidal Mechanism of Neutrophils[J].Journal of Modern Laboratory Medicine,2020,35(01):161-164.[doi:10.3969/j.issn.1671-7414.2020.01.043]
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中性粒细胞杀菌机理的最新研究进展()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年01期
页码:
161-164
栏目:
综述
出版日期:
2020-02-29

文章信息/Info

Title:
Recent Research Progress on Germicidal Mechanism of Neutrophils
文章编号:
1671-7414(2020)01-161-04
作者:
时小淋1a2王晓丰1b刘 鹏1a程艳杰2王明义1a
(1.大连医科大学附属威海市立医院a中心实验室; b消化内科,山东威海 264200; 2. 大连医科大学附属第一医院检验科, 辽宁大连 116000 )
Author(s):
SHI Xiao-lin1a2WANG Xiao-feng1bLIU Peng1aCHENG Yan-jie2WANG Ming-yi1a
(1a. Department of Central Laboratory; 1b. Department of Gastroenterology,Weihai Municipal Hospital Affiliated to Dalian Medical University,Shandong Weihai 264200, China; 2. Department of Clinical Laboratory,the First Affiliated Hospital of DalianMedical University,Liaoning Dalian 116000, China)
关键词:
中性粒细胞 杀菌机制 活性氧分子 脱颗粒 胞外杀菌网络
分类号:
R446.1
DOI:
10.3969/j.issn.1671-7414.2020.01.043
文献标志码:
A
摘要:
中性粒细胞作为外周血中最多的白细胞,在机体免疫应答抵抗外界感染中发挥重要作用。目前,普遍认为中性粒细胞主要通过活性氧杀菌途径、脱颗粒杀菌途径和胞外杀菌网络(Neutrophil Extracellular Traps, NETs)途径杀灭病原体,若其杀菌途径缺失或抑制将导致反复感染,若过度激活也将对机体造成损伤。该文主要针对中性粒细胞杀菌机理的最新研究进展作以综述,以期为后续的中性粒细胞过度激活后具体作用途径以及作用靶点的研究提供理论基础。

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备注/Memo

备注/Memo:
基金项目:威海市医学微生物与免疫学重点实验室; 威海市科技发展计划:H. pylori tfs分泌系统结合区分子结构和功能研究(2016GNS029)。作者简介:时小淋(1994-),女,硕士研究生,技师,研究方向:感染性免疫,E-mail:616081896@qq.com。通讯作者:程艳杰,女,硕士,教授,研究方向:传染性疾病的筛查,E-mail:2845662180@qq.com。王明义(1973-),男,博士,教授,研究方向:感染性免疫,E-mail:wangmingyi1973@outlook.com,为共同通讯作者。收稿日期:2019-11-12 修回日期:2019-12-07
更新日期/Last Update: 2020-03-30