[1]马 平,褚 锋.血浆血栓弹力图与纤维蛋白原及D- 二聚体检测对恶性肿瘤患者凝血功能评估的临床价值[J].现代检验医学杂志,2020,35(02):72-75.[doi:10.3969/j.issn.1671-7414.2020.02.021]
 MA Ping,CHU Feng.Clinical Value of Thrombotic Elastin, Tibrinogen and D-dimer in Evaluatingthe Coagulation Function of Malignant Tumor[J].Journal of Modern Laboratory Medicine,2020,35(02):72-75.[doi:10.3969/j.issn.1671-7414.2020.02.021]
点击复制

血浆血栓弹力图与纤维蛋白原及D- 二聚体检测对恶性肿瘤患者凝血功能评估的临床价值()
分享到:

《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年02期
页码:
72-75
栏目:
论 著
出版日期:
2020-05-24

文章信息/Info

Title:
Clinical Value of Thrombotic Elastin, Tibrinogen and D-dimer in Evaluatingthe Coagulation Function of Malignant Tumor
文章编号:
1671-7414(2020)02-072-04
作者:
马 平1褚 锋2
(1. 湖北省临床检验中心,武汉 430064;2. 武汉大学附属同仁医院/ 武汉市第三医院急救科,武汉 430065)
Author(s):
MA Ping1 CHU Feng2
(1.Hubei Center for Clinical Laboratory, Wuhan 430064,China;2. Department of Emergency, the Third Hospital ofWuhan/Tongren Hospital of Wuhan University, Wuhan 430065, China)
关键词:
恶性肿瘤血栓弹力图(TEG)纤维蛋白原(FIB)D- 二聚体(DD)
分类号:
R730.43
DOI:
10.3969/j.issn.1671-7414.2020.02.021
文献标志码:
A
摘要:
目的 探索分析血浆血栓弹力图(thromboela-stogram,TEG) 与纤维蛋白原(fibrinogen,FIB) 及D- 二聚体(D-dimer,DD) 检测对恶性肿瘤患者凝血功能评估的临床价值。方法 随机选择武汉大学附属同仁医院/ 武汉市第三医院2019 年1~6 月期间收治的恶性肿瘤患者90 例作为研究对象( 治疗随访显示含肿瘤复发患者45 例、肿瘤缓解患者45 例),并随机选取体检中心接纳的健康正常者45 例作为对照组。检测相关恶性肿瘤指标水平并进行对比。结果同健康对照组相比,研究组患者TEG 水平中的R 值及K 值均明显降低(t=3.6233, 3.7274, P<0.05),Angle 角、MA 值及CI 值均明显升高(t=3.6234 ~ 7.6238,均P<0.05);研究组的DD 及FIB 水平均显著超过对照组,差异具有统计学意义(t=25.623,3.6723,P<0.05)。研究组患者干预后复查结果显示,与肿瘤缓解组相比,肿瘤复发组患者TEG 水平中的R 值及K 值均明显降低(t=3.7273,3.7721,P<0.05),差异有统计学意义,Angle 角、MA 值及CI 值明显升高(t=5.7623~6.6283, 均P<0.05);肿瘤复发组的DD 和FIB 水平均显著超过肿瘤缓解组,差异具有统计学意义(t=4.7239~28.723,均P<0.05)。研究组异常率高达86.67%,显著超过正常对照组0.00%,差异具有统计学意义(P<0.05)。结论 针对恶性肿瘤患者积极实施TEG,FIB 及DD 指标的动态监测,有助于科学评估恶性肿瘤凝血功能指标状态,对于对症施治具有重要价值,值得推广应用。

参考文献/References:

[1] 杜秀娟, 曾覃平, 张秀梅, 等. 血栓弹力图?纤维蛋白原及D- 二聚体检测在恶性肿瘤患者凝血功能评估中的应用[J]. 检验医学与临床,2019,16(16):2347-2349,2353.   DU Xiujuan, ZENG Qinping, ZHANG Xiumei, et al.Clinical application of thrombelastogram ,fibrinogenand D-dimer detection in coagulation functionevaluation of patients with malignant tumors [J].Laboratory Medicine and Clinic, 2019,16 (16): 2347-2349, 2353.
[2] 尹志辉, 周志伟, 刘继勇, 等. 乳腺癌患者组织多项组化标记物与血清CA153,CA125,CEA,25-OH-D3水平关联性分析模型建立及在预后判断的临床价值[J]. 现代检验医学杂志,2019,34(3):47-50,54.   YIN Zhihui, ZHOU Zhiwei, LIU Jiyong, etal. Es tablishment of a correlat ion analysismodel between multi-group markers and serumCA153,CA125,CEA,25-OH-D3 in breast cancer patients and clinical value in prognosis [J]. Journal ofModern Laboratory Medicine, 2019,34 (3): 47-50, 54.
[3] 徐丹军.术前D- 二聚体联合纤维蛋白原对早期宫颈癌术后复发的诊断价值[J].中国性科学,2019, 28(8): 41-44.   XU Danjun. Diagnostic value of preoperative D-dimerscombined with fibrinogen in postoperative recurrenceof early cervical cancer [J]. The Chinese Journal ofHuman Sexuality, 2019,28 (8): 41-44.
[4] 张利祥,潘静,赵洁,等.痰液基细胞学检查与血清CYFRA21-1,CEA,NSE 联合检测对肺癌的诊断价值[J]. 现代检验医学杂志,2019,34(3):99-103.   ZHANG Lixiang, PAN Jing, ZHAO Jie, et al. Valueof the combined determination of sputum liquid-basedcytology and serum CYFRA21-1 , CEA,NSE forthe diagnosis of lung cancer [J]. Journal of ModernLaboratory Medicine, 2019,34 (3): 99-103.
[5] 武二伟,司志刚,王琰,等.血浆D- 二聚体及纤维蛋白原水平与肺癌临床病理类型及预后的相关性[J]. 实用医药杂志,2019,36(6):487-489.   WU Erwei, SI Zhigang, WANG Yan, et al. Therelativity of blood D-dimer and fibrinogen to clinicalpathological typies and patients prognosis in patientswith lung cancer [J]. Practical Journal of Medicine &Pharmacy, 2019,36 (6): 487-489.
[6] 刘艳萍,李可成,谢梦月.D- 二聚体与纤维蛋白原联合检测在肿瘤疾病中的应用研究[J].临床医药文献电子杂志,2019,6(7):111-112.   LIU Yanping, LI Kecheng, XIE Mengyue. Study onthe combined detection of D-dimer and fibrinogenin cancer [J]. Electronic Journal of Clinical MedicalLiterature, 2019,6 (7): 111-112.
[7] 刘强,程英升,王永利.D- 二聚体及纤维蛋白原监测在导管接触溶栓治疗急性下肢深静脉血栓形成中的应用[J].介入放射学杂志,2018,27(11):1031-1035.   LIU Qiang, CHENG Yingsheng, WANG Yongli.The application of monitoring of plasma D- dimerand fibrinogen concentrations in treating acute lowerextremity deep venous thrombosis with catheterdirectedthrombolysis [J]. Journal of InterventionalRadiology, 2018,27 (11): 1031-1035.
[8] 范文锋,黄韶荣,罗维.急性脑梗死患者血清中Lp(a),CRP,D- 二聚体及纤维蛋白原水平变化的临床意义[J].中国医药科学,2018,8(19):134-137   FAN Wenfeng, HUANG Shaorong, LUO Wei. Clinicalsignificance of changes of serum Lp(a), C-reactiveprotein, D-dimer and fibrinogen expression in patientswith acute cerebral infarction [J]. Chinese Medicineand Pharmacy, 2018,8 (19): 134-137.
[9] 陈作波,刘秋芳,洪可仲.恶性肿瘤血浆纤维蛋白原和D- 二聚体含量的测定分析[J].现代诊断与治疗,2018,29(14):2259-2261.   CHEN Zuobo, LIU Qiufang, HONG Kezhong.Determination and analysis of plasma fibrinogen andD-dimer content in malignant tumors [J]. ModernDiagnosis and Treatment, 2018,29 (14): 2259-2261.
[10] 赵雅,陈会生,郑伟.缺血性脑卒中患者外周血D-二聚体,hs-CRP 及血小板参数在不同TOAST 分型中的差异研究[J].现代检验医学杂志,2019,34(2):60-63.   ZHAO Ya, CHEN Huisheng, ZHENG Wei. Study onthe differences of D-dimer , hs-CRP and plateletparameters in peripheral blood of patients with ischemicstroke in different TOAST classifications [J]. Journal ofModern Laboratory Medicine, 2019,34 (2): 60-63.
[11] 曹黎娜,石岩.PT,APTT,TT, 纤维蛋白原?纤维蛋白原降解产物与D- 二聚体对产后出血的临床预警价值比较[J].航空航天医学杂志,2018,29(6):651-653.   CAO Li’na, SHI Yan. Comparison of PT,APTT,TT,fibrinogen,fibrinogen degradation products andD-dimer in predicting the clinical value of postpartumhemorrhage [J]. Journal Aerospace Medicine, 2018,29(6): 651-653.
[12] 王玉婷,古丽米拉木·艾热提,刘春花,等.D- 二聚体?纤维蛋白原升高的影响因素及其与恶性实体肿瘤患者临床特征及预后的关系[J].现代肿瘤医学,2018,26(12):1921-1924.   WANG Yuting ,GULIMILAMU·Aireti, LIUChunhua , et al. D-dimer, fibrinogen elevated relatedinfluencing factors and the clinical features andprognosis of malignant solid tumor patients[J]. Journalof Modern Oncology 2018, 26(12) :1921-1924
[13] 汤伟胜,彭刚,王远,等.不同类型脑卒中患者超敏C 反应蛋白?D- 二聚体、纤维蛋白原及炎性因子的相关性研究[J].国际检验医学杂志,2018,39(5):640-641.   TANG Weisheng, PENG Gang, WANG Yuan, etal. Correlation study of hypersensitive C-reactiveprotein, D-dimer, fibrinogen and inflammatory factorsin different types of stroke patients [J]. InternationalJournal of Laboratory Medicine, 2018,39 (5): 640-641.
[14] 武红莉, 田瑞雪, 叶青, 等.B 型脑钠肽?超敏C 反应蛋白?纤维蛋白原?D- 二聚体及血气分析在慢性阻塞性肺疾病急性加重期合并肺动脉高压患者中的表达[J]. 实用临床医药杂志,2018,22(3):31-33, 37.   WU Hongli, TIAN Ruixue, YE Qing, et al.Expressions of brain natriuretic peptide,fibrinogen,hypersensitive C-reactive protein,D-Dimer andarterial blood gas analysis in acute exacerbationof chronic obstructive pulmonary disease patientscomplicated with pulmonary hypertension [J]. Journalof Clinical Medicine in Practice, 2018,22 (3): 31-33 ,37.
[15] 沈海涛,焦荣红,陆志成,等.原发性肝癌患者外周血CD39+,CD73+ 调节性T 细胞和自然杀伤(NK)细胞的表达及其与肝损伤的相关性[J].现代检验医学杂志,2019, 34(1): 10-13.   SHEN Haitao, JIAO Ronghong, LU Zhicheng, et al.Correlation between the expression of peripheral bloodCD39+ and CD73+ in regulatory T cells and nature killcell in patients with hepatocellular carcinoma and liverinjury [J]. Journal of Modern Laboratory Medicine,2019,34 (1): 10-13.

相似文献/References:

[1]余安运,陶丹,刘夏炎,等.肿瘤标志物在消化系统肿瘤早期诊断中的应用[J].现代检验医学杂志,2015,30(06):133.[doi:10.3969/j.issn.1671-7414.2015.06.041]
 YU An-yun,TAO Dan,LIU Xia-yan,et al.Clinical Value of Blood Serums Tumor Marker in Early Diagnosis of Digestive System Neoplasms[J].Journal of Modern Laboratory Medicine,2015,30(02):133.[doi:10.3969/j.issn.1671-7414.2015.06.041]
[2]黄玉斌a,刘 霄a,徐翠香b,等.中晚期恶性肿瘤患者应用PD-1抑制剂多周期治疗对外周血淋巴细胞亚群影响的动态变化研究[J].现代检验医学杂志,2022,37(02):23.[doi:10.3969/j.issn.1671-7414.2022.02.005]
 HUANG Yu-bina,LIU Xiaoa,XU Cui-xiangb,et al.Study on the Dynamic Changes of the Effect of PD-1 Inhibitor Multi-cycle Therapy on Peripheral Blood Lymphocyte Subsets in Patients with Advanced Malignant Tumors[J].Journal of Modern Laboratory Medicine,2022,37(02):23.[doi:10.3969/j.issn.1671-7414.2022.02.005]

备注/Memo

备注/Memo:
作者简介:马平(1978-),女,硕士研究生,主管技师,研究方向:临床实验室质量控制,E-mail:68780142@qq.com。通讯作者:褚锋(1980-),男,临床医学本科,普外科主治医师,E-mail:36684141@qq.com。收稿日期:2019-10-25 修回日期:2019-12-06
更新日期/Last Update: 2020-04-30