[1]于彩霞,巩云霏,闫 苏,等.血清视黄醇结合蛋白4 及骨桥蛋白与绝经后骨质疏松症的相关性研究[J].现代检验医学杂志,2020,35(02):112-115.[doi:10.3969 / j.issn.1671-7414.2020.02.031]
 YU Cai-xia,GONG Yun-fei,YAN Su,et al.Relationship between Serum Retinol Binding Protein 4 and Osteopontin andPostmenopausal Osteoporosis[J].Journal of Modern Laboratory Medicine,2020,35(02):112-115.[doi:10.3969 / j.issn.1671-7414.2020.02.031]
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血清视黄醇结合蛋白4 及骨桥蛋白与绝经后骨质疏松症的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年02期
页码:
112-115
栏目:
检验与临床
出版日期:
2020-05-24

文章信息/Info

Title:
Relationship between Serum Retinol Binding Protein 4 and Osteopontin andPostmenopausal Osteoporosis
文章编号:
1671-7414(2020)02-112-05
作者:
于彩霞巩云霏闫 苏孙国宗赵江彦王会芳
(涿州市医院检验科,河北涿州 072750)
Author(s):
YU Cai-xia GONG Yun-fei YAN Su SUN Guo-zong ZHAO Jiang-yan WANG Hui-fang
(Department of Clinical Laboratory, Zhuozhou Hospital, Hebei Zhuozhou 072750, China)
关键词:
绝经后骨质疏松症视黄醇结合蛋白4骨桥蛋白骨密度
分类号:
R591.1;R446.11
DOI:
10.3969 / j.issn.1671-7414.2020.02.031
文献标志码:
A
摘要:
目的 探讨绝经后妇女血清视黄醇结合蛋白4(retinol binding protein 4,RBP4)及骨桥蛋白(osteopontin,OPN) 水平与骨密度(bone mineral density,BMD) 的关系, 分析其在绝经后骨质疏松症(postmenopousalosteoporosis,PMOP)中的应用价值。方法 对262 例绝经后妇女进行研究双能X 线骨密度仪测量腰椎1-4(L1-4)和左侧股骨颈(FN),测定血中RBP4,OPN,I 型原胶原N- 端前肽(PINP),β- 胶原降解产物(β-CTX),甲状旁腺素(PTH),骨钙素(OC),血钙(Ca)及血磷(P)水平。ROC 曲线分析RBP4 及OPN 诊断PMOP 的价值。结果 骨质疏松组血清 RBP4(μg/ml)(25.13±4.74 , 18.46±4.25 和15.30±3.87)及OPN(ng/ml)(13.58±4.42 , 10.47±3.46 和8.24±3.13)水平均明显高于骨量减少组和正常组,差异有统计学意义(均P < 0.05)。相关分析显示,骨质疏松症组血清RBP4及OPN 水平与β-CTX 呈正相关(r=0.291,0.284,均P < 0.05),与Ca,L1-4 及左FN 骨密度呈负相关(r = - 0.247,-0.513,-0.486,-0.265,-0.556,-0.574,均P < 0.05)。ROC 曲线显示,血清RBP4 及OPN 水平为21.53μg/ml 和12.27 ng/ml 是诊断PMOP 的最佳截值。结论 血清RBP4 及OPN 水平升高与低BMD 相关,是影响PMOP 发生的关键因子。

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:保定市科学计划与发展指导计划项目(16ZF025)。作者简介:于彩霞(1981-),女,本科,副主任技师, 研究方向:主要从事临床骨代谢疾病检验诊断研究。E-mail:caixiaer0366@163.com。通讯作者:王会芳,E-mail:592324720@qq.com。收稿日期:2019-05-07 修回日期:2019-12-02
更新日期/Last Update: 2020-04-30