[1]李卿英.膀胱尿路上皮细胞癌患者外周血NLR,PLR,MLR 和RDW 水平表达及在临床分期评估中的价值[J].现代检验医学杂志,2020,35(04):89-93.[doi:10.3969/j.issn.1671-7414.2020.04.022]
 LI Qing-ying.Expression of NLR, PLR, MLR and RDW in Serum of Bladder Urothelial Cell Carcinoma and Its Value in Clinical Staging[J].Journal of Modern Laboratory Medicine,2020,35(04):89-93.[doi:10.3969/j.issn.1671-7414.2020.04.022]
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膀胱尿路上皮细胞癌患者外周血NLR,PLR,MLR 和RDW 水平表达及在临床分期评估中的价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年04期
页码:
89-93
栏目:
论 著
出版日期:
2020-09-05

文章信息/Info

Title:
Expression of NLR, PLR, MLR and RDW in Serum of Bladder Urothelial Cell Carcinoma and Its Value in Clinical Staging
文章编号:
1671-7414(2020)04-089-05
作者:
李卿英
(西安市第三医院泌尿外科,西安 710082)
Author(s):
LI Qing-ying
(Department of Urology,the Third Hospital of Xi ’an, Xi’an 710082,China)
关键词:
膀胱尿路上皮细胞癌中性粒细胞计数/ 淋巴细胞计数比率血小板计数/ 淋巴细胞计数比率单核细胞计数/ 淋巴细胞计数比率红细胞体积分布宽度分期评估价值
分类号:
R737.14;R730.43
DOI:
10.3969/j.issn.1671-7414.2020.04.022
文献标志码:
A
摘要:
目的 观察膀胱尿路上皮细胞癌外周血中性粒细胞计数/ 淋巴细胞计数比率(NLR),血小板计数/ 淋巴细胞计数比率(PLR),单核细胞计数/ 淋巴细胞计数比率(MLR)和红细胞体积分布宽度(RDW)表达情况,并分析其在临床分期评估中的价值。方法 回顾性分析118 例膀胱尿路上皮细胞癌病例资料,所有病例均于治疗前清晨空腹采血行NLR,PLR,MLR 和RDW 水平表达检测,观察不同临床分期患者外周血NLR,PLR,MLR 和RDW 水平表达差异及相关性,采用ROC 曲线法分析外周血NLR,PLR,MLR 和RDW 在膀胱尿路上皮细胞癌临床分期评估中的效能。结果 患者外周血NLR,PLR 和RDW表达水平随临床分期的提升而提升,外周血MLR表达水平下降,且不同临床分期(TⅠ期、TⅡ期、TⅢ期和TⅣ期) 病例的外周血NLR,PLR,MLR 和RDW 表达比较差异具有统计学意义(F=31.152~56.182,均P < 0.05)。Spearman 秩相关性分析显示:外周血NLR(r = 0.813,P=0.016),PLR(r= 0.881,P=0.013) 和RDW(r = 0.857,P=0.014) 与临床分期呈正相关(P < 0.05);外周血NLR(r = - 0.583,P=0.014) 与临床分期呈负相关(P < 0.05)。ROC曲线数据显示:外周血NLR,PLR,MLR 和RDW 表达水平鉴别临床分期的曲线位于参考线之上,且外周血NLR,PLR,MLR 和RDW 在鉴别TⅠ期与TⅡ期、TⅡ期与TⅢ期、TⅢ期与TⅣ期的准确度、敏感度和特异度均高于80%。结论 外周血NLR,PLR,MLR 和RDW 与膀胱尿路上皮细胞癌临床分期具有相关性,其在鉴别膀胱尿路上皮细胞癌临床分期中具有一定的临床价值。

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备注/Memo

备注/Memo:
收稿日期:2020-02-10修回日期:2020-04-07作者简介:李卿英(1979-),男,本科,主治医师,主要从事泌尿外科相关疾病诊断及治疗,E-mail:610004286@qq.com 。
更新日期/Last Update: 2020-10-08