[1]霍 豆,秦 爽,吴永昌,等.血清总轻链与游离轻链定量检测在多发性骨髓瘤诊断中的临床价值探讨[J].现代检验医学杂志,2020,35(04):87-88,157.[doi:10.3969/j.issn.1671-7414.2020.04.021]
 HUO Dou,QIN Shuang,WU Yong-chang,et al.Clinical Value of Quantitative Detection of sTLC and sFLC in Diagnosis of Multiple Myeloma[J].Journal of Modern Laboratory Medicine,2020,35(04):87-88,157.[doi:10.3969/j.issn.1671-7414.2020.04.021]
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血清总轻链与游离轻链定量检测在多发性骨髓瘤诊断中的临床价值探讨()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年04期
页码:
87-88,157
栏目:
论 著
出版日期:
2020-09-05

文章信息/Info

Title:
Clinical Value of Quantitative Detection of sTLC and sFLC in Diagnosis of Multiple Myeloma
文章编号:
1671-7414(2020)04-087-03
作者:
霍 豆秦 爽吴永昌刘 杨邢瑞青彭道荣赵 茜
(空军军医大学第一附属医院,西安710032)
Author(s):
HUO DouQIN ShuangWU Yong-changLIU YangXING Rui-qingPENG Dao-rongZHAO Qian
(the First Affiliated Hospital of Air Force Military Medical University,Xi’an 710032, China)
关键词:
血清总轻链血清游离轻链多发性骨髓瘤
分类号:
R733.3;R446.11
DOI:
10.3969/j.issn.1671-7414.2020.04.021
文献标志码:
A
摘要:
目的 探讨血清总轻链(serum total light chain,sTLC)与游离轻链(serum free light chain,sFLC) 在多发性骨髓瘤(multiple myeloma, MM) 临床诊断中的应用价值。方法 选取空军军医大学第一附属医院2019 年10 月~2020 年1月期间收治的多发性骨髓瘤患者67 例,采集所选取患者的血清样本,检测sTLC 和sFLC 浓度,进行相应的统计分析。结果 67 例多发性骨髓瘤患者sTLC 和sFLC 检测结果的总符合率为56.72%。在MM诊断中,sFLC 异常检出率(92.54%)高于sTLC(70.15%),差异具有统计学意义(χ2=11.064,P<0.01)。然而,联合检测sTLC 和sFLC 的异常检出率(94.03%)与sFLC 检测(92.54%)比较,差异无统计学意义(P=1.000)。结论 多发性骨髓瘤患者sTLC 与sFLC 检测结果的符合率较低,sTLC 在MM 的诊断中临床价值有限,sFLC 检测可为MM 的早期诊断提供可靠的实验室依据。

参考文献/References:

[1] 蒋翔宁,陈俊峰,汪勇.血清游离轻链κ/λ 比值联合免疫固定电泳在多发性骨髓瘤患者预后评估中的价值[J]. 中国实验血液学杂志, 2020, 28(1):191-195. JIANG Xiangning,CHEN Junfeng,WANGYong. Value of serum free light chain kappa/lambdaratio detection combined with immunofixationelectrophoresis in the prognosis evaluation of patientswith multiple myeloma [J]. Journal of ExperimentalHematology, 2020, 28(1): 191-195.
[2] 王得印, 郝云良, 肖萌, 等. 多发性骨髓瘤流行病学及病因分析[J].国际流行病学传染病学杂志, 2018,45(4): 277-280. WANG Deyin,HAO Yunliang,XIAO Meng,et al.Epidemiology and etiology of multiple myeloma[J].International Journal of Epidemiology and InfectiousDisease, 2018, 45(4): 277-280.
[3] 中国医师协会血液科医师分会.中国医学会血液学分会, 中国多发性骨髓瘤工作组. 中国多发性骨髓瘤诊治指南(2017 年修订)[J]. 中华内科杂志, 2017,56(11): 866-870. Chinese Hematology Association, Chinese Societyof Hematology, Chinese Myeloma Committee-Chinese Hematology Association . The guidelines forthe diagnosis and management of multiple myelomain China (2017 revision) [J]. Chin J Intern Med,2017,56(11): 866-870.
[4] 盘国雄,谭才燕,何嘉颖,等.多发性骨髓瘤患者血清中lncRNA PCAT-1 的表达水平与临床预后研究[J].现代检验医学杂志, 2018, 33(1): 72-76. PAN Guoxiong,TAN Caiyan, HE Jiaying, et al. SerumlncRNA PCAT-1 expression level of patients withmultiple myeloma and clinical value[J]. Journal ofModern Laboratory Medicine, 2018, 33(1): 72-76.
[5] WANG Guihua, CAO Xiaonian, LAI Senyan, etal. PI3K stimulates DNA synthesis and cell-cycleprogression via its p55 PIK regulatory subunitinteraction with PCNA[J]. Molecular CancerTherapeutics, 2013, 12(10): 2100-2109.
[6] 杨卫东,王升,赵艳秋,等.IgG 型多发性骨髓瘤化疗后免疫球蛋白重/ 轻链表达及其与预后的关系[J]. 癌症进展,2018, 16(3): 363-365, 369. YANG Weidong,WANG Sheng,ZHAO Yanqiu,etal. Correlation between the expression of immunoglobulinheavy/light chain ratio after chemotherapy and theprognosis in patients with multiple myeloma of IgGtype[J]. Oncology Progress, 2018, 16(3): 363-365,369.
[7] ZAHARI SHAM S Y, THAMBIAH S C,SAMSUDINI N, et al. Light chain multiple myeloma: an evaluationof its biochemical investigations[J]. The MalaysianJournal of Pathology,2017,39(3): 311-315.
[8] 廖丹,刘霞,李辉军,等.多发性骨髓瘤血、尿总轻链与游离轻链相符率比较及其临床意义[J]. 临床内科杂志,2016,33(4):243-245. LIAO Dan,LIU Xia,LI Huijun,et al. Thecomparison of accordant rate of total light chains andfree light chains in serum and urine and its clinicalsignificance of muitiple myeloma[J]. Journal of ClinicalInternal Medicine, 2016, 33(4): 243-245.
[9] 赵丹,姜佳岐,林琳.血清游离轻链及其κ/λ 比率在多发性骨髓瘤患者中的临床意义研究[J].中国实验血液学杂志, 2019, 27(4): 1173-1178. ZHAO Dan,JIANG Jiaqi,LIN Lin. Clinical significanceof serum free light chain and its κ/λ ratio inpatients with multiple myeloma[J]. Journal of ExperimentalHematology, 2019, 27(4): 1173-1178.
[10] DEJOIE T, CORRE J, CAILLON H, et al. Responsesin multiple myeloma should be assigned according toserum ,not urine ,free light chain measurements[J].Leukemia, 2019, 33(2): 313-318.

备注/Memo

备注/Memo:
收稿日期:2020-04-08修回日期:2020-04-23作者简介:霍豆 (1989-),女,本科,技师,研究方向:临床免疫学检验,E-mail:huodou1@163.com。通讯作者:吴永昌(1975-),男,本科,技师,主要从事临床免疫学检验及临床相关疾病的研究工作,E-mail:sxxawyc@163.com。
更新日期/Last Update: 2020-10-08