[1]何家花,余成强,李步荣.血流感染病原学分析及与相关炎性因子的应用价值研究[J].现代检验医学杂志,2020,35(04):139-142.[doi:10.3969/j.issn.1671-7414.2020.04.035]
 HE Jia-hua,YU Cheng-qiang,LI Bu-rong.Pathogen Analysis of Bloodstream Infection and Study on the Application Value of Related Inflammatory Factors[J].Journal of Modern Laboratory Medicine,2020,35(04):139-142.[doi:10.3969/j.issn.1671-7414.2020.04.035]
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血流感染病原学分析及与相关炎性因子的应用价值研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年04期
页码:
139-142
栏目:
检验与临床
出版日期:
2020-09-05

文章信息/Info

Title:
Pathogen Analysis of Bloodstream Infection and Study on the Application Value of Related Inflammatory Factors
文章编号:
1671-7414(2020)04-139-04
作者:
何家花12余成强2李步荣1
(1. 西安交通大学第二附属医院医学检验科,西安 710004;2. 商洛市中心医院医学检验科,陕西商洛 726000)
Author(s):
HE Jia-hua12 YU Cheng-qiang2 LI Bu-rong1
(1.Department of Medical Laboratory, the Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710004,China;2.Department of Medical Laboratory, Shangluo Central Hospital, Shaanxi Shangluo 726000,China)
关键词:
血流感染中性粒细胞/ 淋巴细胞比值降钙素原诊断效能
分类号:
R515.3;R446.5
DOI:
10.3969/j.issn.1671-7414.2020.04.035
文献标志码:
A
摘要:
目的 分析血流感染(bloodstream infection, BSI)的病原学特点,并研究与其相关炎性因子的应用价值,为血流感染的诊断与治疗提供依据。方法 收集商洛市中心医院2018 年1 月~ 2019 年11 月住院成人患者血培养的结果,回顾性分析阳性血培养的细菌分布特点、科室分布特点及病原菌的耐药情况,然后选取130 例血培养阳性病例作为实验组,185 例血培养阴性病例作为对照组,比较两组间白细胞数(WBC)、中性粒细胞数(NEU#)、中性粒细胞/ 淋巴细胞比值(NLR)、超敏C 反应蛋白(hsCRP)和降钙素原(PCT)的水平差异。并运用受试者工作特征曲线(ROC 曲线)评价WBC,NUE#,NLR,hsCRP 和PCT 在血流感染中的诊断效能。结果 血培养共检出病原菌340 株,其中革兰阴性杆菌171 株,占50.29%;革兰阳性球菌146 株,占42.94%;真菌13 株,占3.82%;其他细菌10 株,占2.94%。检出的病原菌居前列的依次是大肠埃希菌、肺炎克雷伯菌、凝固酶阴性葡萄球菌、金黄色葡萄球菌和屎肠球菌。血培养阳性患者主要来源于重症医学科、神经外科、急诊医学科、神经内科及泌尿外科。产超广谱?- 内酰胺酶(ESBLs) 的大肠埃希菌和肺炎克雷伯菌检出率分别是67.89% 和27.27%,耐甲氧西林金黄色葡萄球菌(MRSA) 和耐碳青霉烯类肠杆菌检出率分别为64.5% 和0.68%。两组间WBC,NEU#,NLR,hsCRP 和PCT 水平比较差异均具有统计学意义(Z=-10.538~ -7.163, 均P<0.05)。PCT,NEU#,NLR,hsCRP 和WBC 的ROC 曲线下面积(AUC)分别是0.849,0.752,0.752,0.751 和0.737。结论 商洛某三甲医院血流感染病原菌以革兰阴性菌为主,病原菌耐药率较高。PCT,NEU#,WBC,NLR 和hsCRP 均可用于血流感染的辅助诊断,但PCT 优于其他检验项目。

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备注/Memo

备注/Memo:
收稿日期:2020-03-03 修回日期:2020-03-10作者简介:何家花(1987-),女,在职硕士,主管检验师,从事临床微生物与分子生物学检测工作,E-mail:745249229@qq.com。通讯作者:李步荣(1972-),男,医学博士,主任检验师,研究生导师,主要从事病毒分子生物学诊断工作,E-mail:liburong@163.com。
更新日期/Last Update: 2020-10-08