[1]陈小冰,张雪梅,陈求凝,等.新生儿坏死性小肠结肠炎患者血清 IL-12 及 IL-17 水平检测及临床意义[J].现代检验医学杂志,2020,35(06):179-182.[doi:doi:10.3969/j.issn.1671-7414.2020.06.044]
 CHEN Xiao-bing,ZHANG Xue-mei,CHEN Qiu-ning,et al.Detection and Clinical Significance of Serum IL-12 and IL-17 Levels inNeonatal Necrotizing Enterocolitis[J].Journal of Modern Laboratory Medicine,2020,35(06):179-182.[doi:doi:10.3969/j.issn.1671-7414.2020.06.044]
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新生儿坏死性小肠结肠炎患者血清 IL-12 及 IL-17 水平检测及临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年06期
页码:
179-182
栏目:
检验与临床
出版日期:
2020-12-30

文章信息/Info

Title:
Detection and Clinical Significance of Serum IL-12 and IL-17 Levels inNeonatal Necrotizing Enterocolitis
文章编号:
1671-7414(2020)06-179-04
作者:
陈小冰张雪梅陈求凝谢邦贵卢玉朱
(三亚中心医院新生儿科,海南三亚 572000)
Author(s):
CHEN Xiao-bingZHANG Xue-mei CHEN Qiu-ning XIE Bang-gui LU Yu-zhu
(Department of Neonatology,Sanya Central Hospital,Hainan Sanya 572000,China)
关键词:
新生儿坏死性小肠结肠炎白细胞介素 -12白细胞介素 -17
分类号:
R722.132;R392.11
DOI:
doi:10.3969/j.issn.1671-7414.2020.06.044
文献标志码:
A
摘要:
目的 探讨新生儿坏死性小肠结肠炎(necritizing enterocolitis,NEC)患儿血清白细胞介素 -12(IL-12)及白细胞介素 -17(IL-17)水平变化及临床意义。方法 选取 80 例新生儿 NEC 作为病例组和 65 例健康新生儿作为对照组。80例 NEC 新生儿根据修正 Bell 分期分为Ⅰ期组(31 例),Ⅱ期组(37 例)和Ⅲ期组(12 例)。对照组于出生 3 天后,病例组于治疗前检测血清 IL-12 及 IL-17 水平变化。应用 ROC 曲线分析血清 IL-12 及 IL-17 水平对新生儿 NEC 的诊断价值。结果 病例组血清 IL-12(63.80±10.27ng/L vs 20.62±5.83 ng/L)及 IL-17(22.73±6.50 ng/L vs 6.35±2.28 ng/L)水平明显高于对照组,差异有统计学意义(t=12.640,9.572,均 P<0.05)。Ⅲ期血清 IL-12(79.30±14.80 ng/L vs 62.40±9.52 ng/L,51.72±7.40 ng/L)及 IL-17(34.60±9.72 ng/L vs 20.85±6.17 ng/L, 14.20±4.38 ng/L)水平均明显高于Ⅰ期和Ⅱ期,差异有统计学意义(F=10.205,7.228,均 P<0.05);且Ⅱ期血清 IL-12 及 IL-17 均明显高于Ⅰ期(P<0.05)。ROC 曲线分析显示,血清 IL-12 及 IL-17 水平诊断新生儿 NEC 的最佳截值分别为 48.75ng/L 和 15.60 ng/L,两项联合诊断新生儿 NEC 的曲线下面积(0.902,95%CI:0.845 ~ 0.963)最大,其敏感度和特异度分别为 90.3% 和 83.5%。结论 血清 IL-12 与 IL-17 水平在新生儿 NEC 中明显升高,且与患儿病情严重程度相关,两项联合检测对新生儿 NEC 诊断具有一定的价值。

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更新日期/Last Update: 2020-12-20