[1]梁培松,王结珍,陈 康,等.广东省中山地区孕早期血清 F-βHCG和 PAPP-A水平中位数系统的建立及对唐氏综合征产前筛查的监测与相关性分析[J].现代检验医学杂志,2021,36(01):44-46.[doi:10.3969/j.issn.1671-7414.2021.01.011]
 LIANG Pei-song,WANG Jie-zhen,CHEN Kang,et al.Establishment of Median System of Serum Markers F-β HCG and PAPP-A for Prenatal Screening in Early Pregnancy and Monitoring of Prenatal Screening and Analysis of the Correlation for Down’s Syndrome in Zhongshan of Guangdong Province[J].Journal of Modern Laboratory Medicine,2021,36(01):44-46.[doi:10.3969/j.issn.1671-7414.2021.01.011]
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广东省中山地区孕早期血清 F-βHCG和 PAPP-A水平中位数系统的建立及对唐氏综合征产前筛查的监测与相关性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年01期
页码:
44-46
栏目:
论 著
出版日期:
2021-02-05

文章信息/Info

Title:
Establishment of Median System of Serum Markers F-β HCG and PAPP-A for Prenatal Screening in Early Pregnancy and Monitoring of Prenatal Screening and Analysis of the Correlation for Down’s Syndrome in Zhongshan of Guangdong Province
文章编号:
1671-7414(2021)01-044-04
作者:
梁培松王结珍陈 康
(中山大学附属中山医院检验医学中心,广东中山,528403)
Author(s):
LIANG Pei-song WANG Jie-zhen CHEN Kang et al
(Center of Medical Laboratory , Zhongshan People’s Hospital Affiliated Zhongshan University, Guangdong Zhongshan 528403, China)
关键词:
孕早期妊娠相关蛋白 A游离 β -人绒毛膜促性腺激素中位数
分类号:
R714.55;R392.11
DOI:
10.3969/j.issn.1671-7414.2021.01.011
文献标志码:
A
摘要:
目的 探讨广东中山地区孕早期产前筛查血清标志物游离 β人绒毛膜促性腺激素( F-βHCG)和妊娠血清相关蛋白 -A(PAPP-A)中位数系统的建立及对唐氏综合征产前筛查的监测与相关性分析。方法 采用 IMMULITE2000全自动化学发光免疫分析系统对 11 566例孕 63~97天孕妇进行 F-βHCG和 PAPP-A浓度检测,采用 SPSS 19.0软件进行统计分析,通过加权回归分析法构建中山地区孕早期血清标志物中位数曲线方程及体重校正曲线方程;采用配对 t检验进行中山地区数据与 Prisca4软件内置数据进行比较。结果 建立了中山地区人群模型的孕早期血清标志物中位数系统,中山地区的 F-βHCG浓度中位数均高于软件内置中位数,平均高出 7%;中山地区的 PAPP-A浓度中位数均低于软件内置中位数,平均低出 13%;中山地区人群模型所得的中位数倍数值中位值( mMOM)稳定在 0.95~1.05范围内,假阳性率为 5.0%。结论 建立的中山地区孕早期孕妇血清标志物中位数系统更符合该地区人群特点,更能提高该实验室产前筛查的质量。

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备注/Memo

备注/Memo:
基金项目:2017年度中山市社会公益科技研究项目(2017B1024)。
作者简介:梁培松(1976-),男,本科,副主任技师,主要从事临床检验免疫工作和研究, E-mail:mark113388@163.com。
通讯作者:王伟佳,男,博士后,主任技师,E-mail: weijiawangcn@163.com。
更新日期/Last Update: 2021-02-05