[1]丁亚丽.子宫内膜异位综合征患者血清 AMH和 IGF-1水平表达对不孕症术后妊娠的影响[J].现代检验医学杂志,2021,36(01):120-123.[doi:10.3969/j.issn.1671-7414.2021.01.030]
 DING Ya-li.Effect of Serum AMH and IGF-1 Expression Levels on Postoperative Pregnancy in Infertility Patients with Endometriosis Syndrome[J].Journal of Modern Laboratory Medicine,2021,36(01):120-123.[doi:10.3969/j.issn.1671-7414.2021.01.030]
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子宫内膜异位综合征患者血清 AMH和 IGF-1水平表达对不孕症术后妊娠的影响()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年01期
页码:
120-123
栏目:
检验与临床
出版日期:
2021-02-05

文章信息/Info

Title:
Effect of Serum AMH and IGF-1 Expression Levels on Postoperative Pregnancy in Infertility Patients with Endometriosis Syndrome
文章编号:
1671-7414(2021)01-120-04
作者:
丁亚丽
(濮阳市安阳地区医院检验科 ,河南安阳 455000)
Author(s):
DING Ya-li
(Department of Clinical Laboratory, Anyang District Hospital of Puyang, Henan Anyang 455000, China)
关键词:
子宫内膜异位症抗苗勒管激素胰岛素样生长因子 -1不孕症
分类号:
R711.71;R392.11
DOI:
10.3969/j.issn.1671-7414.2021.01.030
文献标志码:
A
摘要:
目的 探讨血清抗苗勒管激素( AMH)、血清胰岛素样生长因子 -1(IGF-1)对子宫内膜异位综合征不孕患者不孕症术后妊娠的影响。方法 回顾性分析濮阳市安阳地区医院 2016年 3月 ~2018年 3月收治的 112例子宫内膜异位综合征不孕患者临床资料,所有患者均行根治手术,根据患者术后 1年内自然妊娠情况分为妊娠组 51例和未妊娠组 61例,再根据妊娠组中自然妊娠时间分为 A组(术后 6个月内妊娠) 18例,B组(术后 6~12个月内妊娠) 33例。比较妊娠组、未妊娠组 AMH和 IGF-1水平,A组、B组 AMH和 IGF-1水平,通过 Spearman相关性分析 AMH,IGF-1水平与术后自然妊娠、自然妊娠时间的关系。结果 妊娠组术前 AMH,IGF-1水平高于未妊娠组,差异有统计学意义( t=11.494,5.767,均 P< 0.05),术后妊娠组 AMH,IGF-1水平高于未妊娠组,差异有统计学意义( t=12.702,5.957,均 P< 0.05);A组术前 AMH和 IGF-1水平高于 B组,差异有统计学意义( t=3.674,2.053,均 P< 0.05),术后 A组 AMH和 IGF-1水平明显高于 B组,差异有统计学意义( t=3.032,2.526,均 P< 0.05);AMH和 IGF-1水平与术后自然妊娠呈正相关( r=0.547, 0.481,均 P<0.001),与术后自然妊娠时间呈负相关( r=-0.446, -0.521,均 P<0.001)。结论 子宫内膜异位症不孕患者术前 AMH和 IGF-1水平高表达可提高术后自然妊娠率,减少自然妊娠时间。

参考文献/References:

[1] 田艳,赖冬,龙敏,等.厦门地区 2 200例女性不孕患者 AMH水平分析 [J].中国优生与遗传杂志 ,2016,24(9):103-104. TIAN Yan,LAI Dong,LONG Min,et al. Analysis of the changes of anti-mulerian hormone about 2 200 women with infertility in Xiamen [J]. Chinese Journal of Birth Health & Heredity, 2016,24(9):103-104.
[2] LEI Fangliang, LIU Danmeng, YUAN Shen, et al. Study on the influence of pregnancy-induced hypertension on neonatal birth weight[J]. Journal of Investigative Medicine, 2018, 66(6): 626.
[3] 汪银,赵卫东.卵泡输出率对子宫内膜异位症不孕患者 IVF-ET受精及妊娠的影响 [J].山东医药 ,2016,56(19):72-74. WANG Yin ,ZHAO Weidong . Effect of follicular output rate on ovarian response and IVF-ET outcome in infertile patients with endometriosis[J].Shandong Medical Journal, 2016, 56(19):72-74.
[4] MICHIO K, NAOKO M, KEN T, et al. Histomorpho-logical aspects of the ovarian cortex regarding ovarian reserve and local pelvic inflammation[J]. Journal of Mammalian Ova Research, 2018, 35(1): 21-26.
[5] 侯丽明,王佳慧.抗苗勒管激素在卵巢子宫内膜异位囊肿患者血清中的表达及临床意义 [J].中国综合临床 , 2017, 33(12):1131-1134. HOU Liming,WANG Jiahui. Expression of AMH in the serum of patients with ovarian endometriosis cyst and its clinical signi.cance[J].Clinical Medicine of China, 2017, 33(12):1131-1134.
[6] 郎景和,崔恒,戴毅,等. 2015年子宫内膜异位症的诊治指南专家解读 [J].中华妇产科杂志, 2017, 52(12):857-861. LANG Jinghe, CUI Heng, DAI Yi , et al. Expert interpretation of 2015 guidelines for diagnosis and treatment of endometriosis [J]. Chinese Journal of Obstetrics and Gynecology, 2017, 52(12):857-861.
[7] 焦海宁,朱岚,吴步初,等.子宫内膜异位症患者腹腔镜术后生殖预后的影响因素分析 [J].中国医师杂志 , 2018, 20(12):1807-1809,1813. JIAO Haining,ZHU Lan,WU Buchu,et al. Clinical factors of reproductive outcome after laparoscopic treatment in patients with endometriosis[J].Journal of Chinese Physician, 2018, 20(12):1807-1809,1813.
[8] LIU F M,ZHAO M, WANG M,et al. Effect of regular oral intake of aspirin during pregnancy on pregnancy outcome of high-risk pregnancy-induced hypertension syndrome patients[J]. European Review for Medical and Pharmacological Sciences, 2016, 20(23):5013-5016.
[9] 张志鸿,宫榭阳,葛长宇,等 .子宫内膜容受性与内异症合并不孕的关系 [J].中国医师进修杂志, 2017, 40(12): 1146-1149. ZHANG Zhihong ,GONG Xieyang ,GE Changyu,et al. Relationship between endometrial receptivity and infertility in endometriosis[J].Chinese Journal of Postgraduates of Medicine, 2017, 40(12):1146-1149.
[10] AINAHI A, ZIANE A, WAKRIM L, et al. An unusual case of Gullo’s syndrome concomitant with serious endometriosis disease in a postmenopausal woman[J]. Case Reports in Medicine, 2018, 17(61): 1-4.
[11] 魏佳,卢春梅,邵勇,等.不同输卵管系膜状态子宫内膜异位囊肿患者术后血清抗苗勒管激素水平差异分析 [J].新乡医学院学报 , 2019, 36(6):566-570. WEI Jia,LU Chunmei,SHAO Yong,et al. Analysis of the difference of serum anti-mullerian hormone levels in patients with endometriotic cysts with different mesosalpinal status after ovarian cystectomy[J]. Journal of Xinxiang Medical University, 2019, 36(6):566-570.
[12] MITSUI T , MASUYAMA H ,EGUCHI T, et al. Sex differences in early growth during the .rst three years of life in offspring from mothers with pregnancy-induced hypertension[J]. Pregnancy Hypertension: an International Journal of Women’s Cardiovascular Health, 2016, 6(4): 361-366.
[13] 孙莉.腹腔镜联合药物治疗子宫内膜异位症的疗效及对患者生育的影响 [J].检验医学与临床 , 2016, 13(2): 212-214, 217. SUN Li. Efficacy of laparoscopy combined with medication in treating endometriosis and its impact on fertility[J].Laboratory Medicine and Clinic, 2016, 13(2):212-214.
[14] BANOO S, MAKHDOOMI T A, MIR S, et al. Incidence of help syndrome in severe pregnancy induced hypertension and its impact on maternal and fetal outcome[J]. J K Practitioner, 2007,14(2):92-94.
[15] 毛轶凡,何莲芝,张莉亚. AMH评估手术联合 Gnrh-a治疗卵巢子宫内膜异位症时卵巢功能恢复情况的研究 [J].齐齐哈尔医学院学报 , 2016, 37(25):3137-3140. MAO Yifan , HE Lianzhi ,ZHANG Liya . Predictive effect of AMH on ovarian function changes in the treatment of ovarian endometriosis [J]. Journal of Qiqihar University of Medicine, 2016, 37(25):3137-3140.
[16] 李珍,赖光锐,赵彦艳.多囊卵巢综合征和子宫内膜异位症抗苗勒管激素检测意义分析 [J].中国实用妇科与产科杂志 , 2017,33(6):641-643. LI Zhen,LAI Guangrui,ZHAO Yanyan. Analysis of the detection of anti-Müllerian hormone in polycystic ovary syndrome and endometriosis [J]. Chinese Journal of Practical Gynecology and Obstetrics, 2017,33(6):641-643.
[17] FUKUDA S, HIRATA T, NERIISHI K, et al. Thoracic endometriosis syndrome:comparison between catamenial pneumothorax or endometriosis-related pneumothorax and catamenial hemoptysis[J]. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 2018, 225(12): 118-123.
[18] 赵俊波,肖赟赟,杨清.重度卵巢型子宫内膜异位症患者术前 AMH水平对术后自然妊娠评估的应用意义 [J].现代妇产科进展 , 2019,28(1):26-30. ZHAO Junbo,XIAO Yunyun,YANG Qing. Signi.cance of preoperative AMH level in assessment of natural pregnancy after severe ovarian endometriosis[J]. Prog-ress in Obstetrics and Gynecology, 2019,28(1):26-30.
[19] WU Gengxiang , BERSINGER N A, MUELLER M D, et al. Intrafollicular inflammatory cytokines but not steroid hormone concentrations are increased in naturally matured follicles of women with proven endometriosis [J]. Journal of Assisted Reproduction & Genetics, 2017, 34(3):357-364..
[20] JUNAID R. Re: Spontaneous hemoperitoneum in pregnancy (SHiP) and endometriosis - A systematic review of the recent literature[J]. European Journal of Obstetrics & Gynecology & Reproductive Biology, 2018, 223:140-141.

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备注/Memo

备注/Memo:
作者简介:丁亚丽(1987-),女,本科,主管技师,研究方向:生化检验, E-mail:gew139975@163.com。
更新日期/Last Update: 2021-02-05