[1]马飞艳,王　娟,樊　萍.川崎病患儿血清趋化素和缺血修饰清蛋白水平与冠状动脉损伤的相关性及在治疗中的应用价值[J].现代检验医学杂志,2021,36(03):72-75.[doi:10.3969/j.issn.1671-7414.2021.03.016]
　MA Fei-yan,WANG Juan,FAN Ping.Relationship between the Levels of Chemokine and Ischemia-modified Albuminin Serum and Coronary Artery Injury in Children with Kawasaki Disease and the Application Value in the Treatment[J].Journal of Modern Laboratory Medicine,2021,36(03):72-75.[doi:10.3969/j.issn.1671-7414.2021.03.016]
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川崎病患儿血清趋化素和缺血修饰清蛋白水平与冠状动脉损伤的相关性及在治疗中的应用价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年03期
页码:
72-75
栏目:
论　著
出版日期:
2021-05-31

文章信息/Info

Title:
Relationship between the Levels of Chemokine and Ischemia-modified Albuminin Serum and Coronary Artery Injury in Children with Kawasaki Disease and the Application Value in the Treatment
文章编号:
1671-7414（2021）03-072-04
作者:
马飞艳; 王　娟; 樊　萍
(1. 咸阳市妇幼保健院检验科 , 陕西咸阳 712000；2. 陕西省森工医院检验科 , 西安 710300；3. 咸阳市第一人民医院检验科 , 陕西咸阳 712000)
Author(s):
MA Fei-yan1;  WANG Juan2;  FAN Ping3
（1.Department of Clinical Laboratory,the Maternal and Child Health Hospital of Xianyang, Shaanxi Xianyang712000, China ；2.Department of Clinical Laboratory, the Forest Industry Hospital of Shaanxi, Xi’an 710300，China ；3.Department of Clinical Laboratory,the First People’s Hospital of Xianyang, Shaanxi Xianyang 712000, China）
关键词:
川崎病; 冠状动脉损伤; 趋化素; 缺血修饰清蛋白
分类号:
R551.2；R392.11
DOI:
10.3969/j.issn.1671-7414.2021.03.016
文献标志码:
A
摘要:
目的　探讨血清趋化素 (Chemerin) 和缺血修饰清蛋白 (Ischemia-modified albumin,IMA) 水平与川崎病 (Kawasakidisease,KD) 患儿冠状动脉损伤的相关性及在治疗中的应用。方法　选取 2014 年 8 月 ~2019 年 8 月在咸阳市第一人民医院、陕西省森工医院和咸阳市妇幼保健院就诊的 75 例 KD 患儿作为研究对象。依据患儿超声心动图结果分为冠状动脉正常组 (normal coronary artery,NCA)48 例组和冠状动脉病变组 (Coronary artery disease,CAD)27 例，选取 32 例同期体检健康者作为对照组。KD 患儿血清 Chemerin 水平检测采用酶联免疫吸附试验法。IMA 水平检测采用清蛋白 - 钴结合法。通过彩色多普勒超声检查分析 KD 患儿的冠状动脉左主干 (left main coronary artery,LMCA) 内径，左前降支 (left anteriordescending coronary artery,LADC) 内径及右冠状动脉近端 (proximal right coronary artery,PRCA) 内径。比较分析以上指标的变化与 KD 患儿冠状动脉损伤的相关性。结果　对照组和 NCA 组患儿治疗后和治疗前 ,CAD 组患儿治疗后和治疗前的血清 Chemerin 和 IMA 水平分别为 203.32±26.37，247.50±36.42, 317.50±52.16，279.21±45.63，356.89±59.28ng/ml 和 41.20±11.37，55.39±17.45，76.36±26.18，69.50±22.23，92.67±33.49U/ml。NCA 组和 CAD 组患儿治疗前的Chemerin 和 IMA 水平与对照组比较明显增高 , 其中 CAD 组增高更显著。NCA 组和 CAD 组患儿治疗后的 Chemerin 和IMA 水平与对照组比较明显增高 , 其中 CAD 组增高更显著，差异均有统计学意义 (F=31.50~36.10, 均 P=0.000)。CAD组患儿治疗前的血清Chemerin和IMA水平分别与LMCA内径、LADC内径和PRCA内径呈正相关性（rChemerin=0.693, 0.652,0.637, 均 P<0.01;rIMA=0.669, 0.620, 0.619, 均 P<0.01）。结论 IMA 和 Chemerin 可能与 KD 的发生发展密切相关。检测IMA 和 Chemerin 水平可以为 KD 的诊治及冠状动脉损伤的评估提供依据。

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备注/Memo

备注/Memo:
作者简介：马飞艳（1984-），女，大学本科，主管检验师，研究方向：心血管疾病的实验室诊断，E-mail：407530263@qq.com。
通讯作者：王娟（1987-)，女，大学本科，主管检验师，研究方向：心血管疾病的实验室诊断，E-mail：1781292176@qq.com。
更新日期/Last Update: 1900-01-01