[1]岳晓琳,米晓燕,白圆圆,等.原发性舍格伦综合征患者血浆弗林蛋白酶和Th1型细胞因子水平表达与唇腺损害及相关腺体功能的关系研究[J].现代检验医学杂志,2021,36(04):10-14.[doi:10.3969/j.issn.1671-7414.2021.04.003]
 YUE Xiao-lin,MI Xiao-yan,Bai Yuan-yuan,et al.Relationship between Plasma FURIN and Th1 Type Cytokines Level, LabialGland Damage and Related Glandular Function in Patients with PrimarySjogren’s Syndrome[J].Journal of Modern Laboratory Medicine,2021,36(04):10-14.[doi:10.3969/j.issn.1671-7414.2021.04.003]
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原发性舍格伦综合征患者血浆弗林蛋白酶和Th1型细胞因子水平表达与唇腺损害及相关腺体功能的关系研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年04期
页码:
10-14
栏目:
论 著
出版日期:
2021-07-31

文章信息/Info

Title:
Relationship between Plasma FURIN and Th1 Type Cytokines Level, LabialGland Damage and Related Glandular Function in Patients with PrimarySjogren’s Syndrome
文章编号:
1671-7414(2021)04-010-06
作者:
岳晓琳米晓燕白圆圆周红敏
(邯郸市中心医院免疫科 河北邯郸 056000)
Author(s):
YUE Xiao-lin MI Xiao-yan Bai Yuan-yuan Zhou Hong-min
(Department of Immunology, Handan Central Hospital, Hebei Handan, 056000, China)
关键词:
原发性舍格伦综合征弗林蛋白酶辅助性T 细胞1 型唇腺损害腺体功能
分类号:
R593.2;R392.11
DOI:
10.3969/j.issn.1671-7414.2021.04.003
文献标志码:
A
摘要:
目的 探讨原发性舍格伦综合征(pSS)患者血浆弗林蛋白酶(FURIN)和辅助性T 细胞1(Th1)型细胞因子水平表达与唇腺损害及相关腺体功能的关系。方法 将邯郸市中心医院2017 年8 月~ 2019 年8 月收治的pSS 患者109 例作为pSS 组,选取同期于邯郸市中心医院体检的健康志愿者90 例作为对照组。比较两组血浆FURIN 水平及Th1型细胞因子[ 白介素(IL)-2,IL-7,γ 干扰素(INF-γ)] 与Th2 型细胞因子(IL-4,IL-13)水平。根据欧洲抗风湿联盟舍格伦综合征疾病活动指数(ESSDAI)将患者分成轻度组(n=37)、中度组(n=48)和重度组(n=24),比较三组上述各指标水平与唇腺损害及相关腺体功能指标(唾液流率、唇腺病理分级和Schirmer 试验)水平。分析pSS 患者抗SSA 抗体、抗SSB 抗体、血浆FURIN 及Th1 和Th2 型细胞因子的关系,并观察血浆FURIN 水平和Th1,Th2 型细胞因子水平与唇腺损害及相关腺体功能指标的相关性。结果 pSS 组血浆FURIN 及血清IL-2,IL-7,INF-γ,IL-4,IL-13 水平均高于对照组(t=8.054~156.875,均P < 0.05),Th1/Th2 低于对照组(t=3.624,P=0.000)。中、重度组血浆FURIN 及血清IL-2,IL-7,INF-γ,IL-4,IL-13 水平、唇腺病理评分高于轻度组(t=5.339~36.092,均P < 0.05),且重度组高于中度组(t=4.240~13.707,均P < 0.05),而中、重度组Th1/Th2,唾液流率及左、右眼Schirmer 试纸浸湿长度低于轻度组(t=3.013~42.715,均P < 0.05),且重度组低于中度组(t=3.178~18.641,均P < 0.05),差异均有统计学意义。抗SSA 抗体、抗SSB 抗体阳性患者的血浆FURIN 水平及血清IL-2,IL-7,INF-γ,IL-4,IL-13 水平高于阴性患者(t=2.560~14.333,均P < 0.05),Th1/Th2 低于阴性患者(t=2.363~4.604,均P < 0.05),差异有统计学意义。血浆FURIN水平与血清IL-2,IL-7,INF-γ,IL-4,IL-13 水平及唇腺病理评分呈正相关(r=0.362~0.640,均P< 0.05),与Th1/Th2,唾液流率及左、右眼Schirmer 试纸浸湿长度呈负相关(r=-0.715~-0.404,均P < 0.05)。结论 pSS 患者血浆FURIN 水平明显升高,且其水平变化和Th1 及Th2 型细胞因子水平与唇腺损害及相关腺体功能指标相关,临床可能通过测定血浆FURIN 水平,进一步了解pSS 的发病机制。

参考文献/References:

[1] 张欢, 刘春红, 吴斌. 原发性干燥综合征的流行病学研究进展[J]. 现代预防医学,2020,47(16):3056-3058,3063.ZHANG Huan, LIU Chunhong, WU Bin . Advancesin the epidemiology of primary Sj(o)gren’s syndrome[J]. Modern Preventive Medicine, 2020, 47(16):3056-3058,3063.
[2] 王静,佘春晖,刘斌.原发性干燥综合征的研究进展[J]. 中国药物与临床,2019,19(16):2762-2763.WANG Jing, SHE Chunhui, LIU Bin. Researchprogress of primary Sjogren’s syndrome[J]. ChineseRemedies & Clinics, 2019, 19(16):2762-2763.
[3] 侯佳奇,薛鸾.原发性干燥综合征发病机制概述[J].现代免疫学,2019,39(1):58-63.HOU Jiaqi, XUE Luan. Overview of pathogenesis ofprimary Sjogren’s syndrome[J]. Current Immunology,2019, 39(1):58-63.
[4] 高硕,徐学静,王森,等.免疫性血小板减少患者外周血Treg 及Th1,Th2 细胞检测及其临床意义[J].现代检验医学杂志, 2018, 33(1): 112-114.GAO Shuo, XU Xuejing, WANG Sen, et al. Detectionand clinical significance of Treg and Th1,Th2cells in peripheral blood of patients with immunethrombocytopenia [J]. Journal of Modern LaboratoryMedicine, 2018, 33(1): 112-114.
[5] SAKAKIBARA R, HIRANO S, ASAHINA M, etal. Primary Sjogren’s syndrome presenting withgeneralized autonomic failure[J]. European Journal ofNeurology, 2004, 11(9): 635-638.
[6] RANTA N, VALLI A, GR?NHOLM A, et al.Proprotein convertase enzyme FURIN is upregulatedin primary Sj?gren’s syndrome[J]. Clinical andExperimental Rheumatology, 2018, 36 Suppl 112(3):47-50.
[7] 董怡, 张奉春. 干燥综合征:Sjogren’s syndrome[M].北京: 人民卫生出版社,2015:18.DONG Yi, ZHANG Fengchun. Sjogren’s syndrome[M].Beijing:People’s Health Publishing House,2015:18.
[8] 于孟学. 现代风湿性疾病·图谱[M]. 北京: 军事医学科学出版社,2004:58.YU Mengxue. Atlas of Modern rheumatic diseases [M].Beijing: Military Medical Science Press, 2004:58.
[9] SEROR R, THEANDER E, BRUN J G, et al. Validationof EULAR primary Sj?gren’s syndrome disease activity(ESSDAI) and patient indexes (ESSPRI)[J]. Annals ofthe Rheumatic Diseases, 2015, 74(5): 859-866.
[10] 王柏山. 原发性干燥综合征患者外周血Th17 细胞及CXCL13 检测及其临床意义[J]. 国际检验医学杂志,2018, 39(14):1705-1707,1711.WANG Baishan. Expression and significance of TH17cell and chemokine CXCL13 in peripheral bloodof patients with primary Sj?gren’s syndrome [J].International Journal of Laboratory Medicine, 2018,39(14):1705-1707,1711.
[11] 朱东胜,黄卫,王晔.以运动迟缓、肌强直为首发表现的原发性干燥综合征1 例[J]. 中国现代医学杂志,2019,29(7):127-128.ZHU Dongsheng, HUANG Wei, WANG Ye. A caseof primary Sjogren’s syndrome with bradykinesia andmyotonia as the first manifestation[J]. China Journal ofModern Medicine, 2019, 29(7):127-128.
[12] 张友义,刘伟娜,赵慧娜,等.Furin 的生物学功能[J].生命的化学, 2019, 39(2):353-359.ZHANG Youyi, LIU Weina, ZHAO Huina, et al. Thebiological functions of Furin [J]. Chemistry of Life,2019, 39(2):353-359.
[13] 刘恒, 石冲, 伊凤蕊, 等. 宫颈癌组织中Furin 和VEGF 的表达研究[J]. 中国妇幼保健,2018,33(23):5325-5327.LIU Heng, SHI Chong, YIN Fengrui, et al. Expressionof Furin and VEGF in cervical cancer[J]. Maternal &Child Health Care of China, 2018, 33(23):5325-5327.
[14] 汪洋,吕宸,束会娟,等.Furin 在神经精神疾病中作用机制的研究进展[J].生命科学,2020,32(5):439-445.WANG Yang, L? Chen, SHU Huijuan, et al. Researchprogress on the role and mechanisms of Furin inneurobiological diseases [J]. Chinese Bulletin of LifeSciences, 2020,32(5):439-445.
[15] VANKADARI N. Structure of Furin protease bindingto SARS-CoV-2 spike glycoprotein and implicationsfor potential targets and virulence[J]. The Journal ofPhysical Chemistry Letters, 2020, 11(16): 6655-6663.
[16] 李冠东, 颜则行, 孙水. 重组Furin 蛋白对类风湿关节炎滑膜细胞生物学行为的影响[J]. 中国矫形外科杂志,2017,25(7):646-651.LI Guandong, YAN Zexing, SUN Shui. Effect ofrecombinant Furin protein on biological behavior ofsynoviocytes in rheumatoid arthritis[J]. OrthopedicJournal of China , 2017, 25(7):646-651.
[17] 黄逸婷, 张梅. 白介素-2 和白介素-2 受体的调控在自身免疫性疾病和器官移植中的作用[J]. 免疫学杂志,2017,33(10):911-915.HUANG Yiting, ZHANG Mei. The role of IL-2and IL-2 recepter in autoimmune diseases andorgan transplant [J]. Immunological Journal, 2017,33(10):911-915.
[18] 姚建丽,柴向斌.IL-7 与临床相关疾病关系的研究进展[J]. 国际免疫学杂志,2019,42(4):442-445.YAO Jianli, CHAI Xiangbin. Research progress oninterleukin-7 in related diseases [J]. InternationalJournal of Immunology, 2019, 42(4):442-445.
[19] 赵小莹,白宁,陈群,等.干燥综合征患者血清抗α- 胞衬蛋白、抗SSA/SSB 抗体、IFN-γ 及TNF-α 与唇腺病理损害相关性研究[J]. 陕西医学杂志,2020,49(2):241-246.ZHAO Xiaoying, BAI Ning, CHEN Qun, et al.Correlation between serum anti-α-lining protein,anti-SSA/SSB antibody ,IFN-γ and TNF-α andpathological damage of labial glands in patients withSjogren’s syndrome [J]. Shaanxi Medical Journal,2020, 49(2):241-246.
[20] 陈家丽,金月波,李静,等.原发性干燥综合征患者临床和血清学性别差异分析及其发病机制研究[J]. 中华风湿病学杂志,2018,22(8):526-531.CHEN Jiali, JIN Yuebo, LI Jing, et al. Genderdifferences in clinical and immunological characteristicsand the pathogenic study of primary Sj(o)gren’ssyndrome [J]. Chinese Journal of Rheumatology , 2018,22(8):526-531.
[21] 刘英, 姜萍, 王晓萌, 等. 原发性干燥综合征免疫细胞相关因子的研究进展[J].山东医药,2017,57(18):103-105.LIU Ying, JIANG Ping, WANG Xiaomeng, et al.Research progress of immune cell-related factors inprimary Sjogren’s syndrome[J].Shandong MedicalJournal,2017,57(18):103-105.
[22] JAIN A, SRINIVAS B H, EMMANUEL D, et al.Renal involvement in primary Sjogren’s syndrome:a prospective cohort study[J]. RheumatologyInternational, 2018, 38(12): 2251-2262.
[23] 周丽芳, 姜帆, 王媛, 等. 血清学指标结合ESSDAI在原发性干燥综合征中的临床价值[J]. 检验医学与临床,2018,15(5):577-579, 582.ZHOU Lifang, JIANG Fan, WANG Yuan, et al. Clinicalvalue of serum markers combined with ESSDAI inprimary Sjogren syndrome [J]. Laboratory Medicineand Clinic, 2018, 15(5):577-579,582.

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备注/Memo

备注/Memo:
基金项目:河北省医学科学研究重点课题(编号:20170756)。
作者简介: 岳晓琳(1986-),女,硕士,主治医师,研究方向:舍格伦综合征,E-mail:yuexiaolin2009@163.com。
更新日期/Last Update: 1900-01-01