[1]关小明a,陈 锴b,王文会c.冠状动脉粥样硬化性心脏病患者血清骨形态发生蛋白4,N1-甲基烟酰胺和血管生成素样蛋白8水平检测的临床意义[J].现代检验医学杂志,2021,36(04):15-20.[doi:10.3969/j.issn.1671-7414.2021.04.004]
 GUAN Xiao-minga,CHEN Kaib,LIANG Wen-huic.Clinical Significance of Detection of Serum Bone Morphogenetic Protein 4,N1-Methylnicotinamide and Angiopoietin-Like Protein 8 Levels in Patientswith Coronary Atherosclerotic Heart Disease[J].Journal of Modern Laboratory Medicine,2021,36(04):15-20.[doi:10.3969/j.issn.1671-7414.2021.04.004]
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冠状动脉粥样硬化性心脏病患者血清骨形态发生蛋白4,N1-甲基烟酰胺和血管生成素样蛋白8水平检测的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年04期
页码:
15-20
栏目:
论 著
出版日期:
2021-07-31

文章信息/Info

Title:
Clinical Significance of Detection of Serum Bone Morphogenetic Protein 4,N1-Methylnicotinamide and Angiopoietin-Like Protein 8 Levels in Patientswith Coronary Atherosclerotic Heart Disease
文章编号:
1671-7414(2021)04-015-06
作者:
关小明a陈 锴b王文会c
(佛山市中医院 a. 检验科;b. 内科;c. 心血管内科 , 广东佛山 528000)
Author(s):
GUAN Xiao-minga CHEN Kaib LIANG Wen-huic
(a. Department of Clinical Laboratory; b. Department of Internal Medicine;c. Department of Internal Medicine-Neurology,Foshan Hospital of Traditional Chinese Medicine, Guangdong Foshan 528000, China)
关键词:
冠心病骨形态发生蛋白4N1- 甲基烟酰胺血管生成素样蛋白8血脂炎症因子冠脉病变
分类号:
R541.4;R392.11
DOI:
10.3969/j.issn.1671-7414.2021.04.004
文献标志码:
A
摘要:
目的 研究冠状动脉粥样硬化性心脏病(coronary heart disease, CHD)患者血清骨形态发生蛋白4(bonemorphogenetic protein 4, BMP-4),N1- 甲基烟酰胺(N1-methylnicotinamide, me-Nam)和血管生成素样蛋白8(angiopoietinlikeprotein 8, ANGPTL8)水平检测的临床意义。方法 选取2018 年1 月~ 2020 年1 月佛山市中医院诊治的86 例CHD 患者作为CHD 组,以健康体检的60 例健康人群为对照组,检测CHD 组及对照组血清BMP-4,me-Nam,ANGPTL8,血脂及炎症因子水平。比较不同冠状动脉狭窄程度、不同病变支数患者血清BMP-4,me-Nam 及ANGPTL8 水平。Pearson 线性相关分析CHD 组患者血清BMP-4,me-Nam 和ANGPTL8 之间的相关性及三者与Gensini 积分、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和超敏C 反应蛋白(hs-CRP)的相关性。ROC 曲线分析血清BMP-4,me-Nam,ANGPTL8及联合检测对CHD 组患者的诊断价值。结果 与对照组相比,CHD 组患者高血压史、糖尿病史占比较高,TC,TG,LDL-C,IL-6,TNF-α 及hs-CRP 水平明显增高,HDL-C 水平明显降低,差异均有统计学意义(t=5.950~28.084, 均P<0.05)。与对照组相比,CHD 组患者血清BMP-4,me-Nam,ANGPTL8 水平明显增高,差异均有统计学意义(t=14.201,13.495, 37.538, 均P<0.05)。随着Gensini 积分升高或病变支数的增加,CHD 患者的血清BMP-4,me-Nam,ANGPTL8有逐渐升高的趋势(χ2=80.976, 75.688, 108.641, 均P<0.05)。CHD 患者血清BMP-4 表达与me-Nam,ANGPTL8 表达呈显著正相关(r=0.567, 0.610, 均P<0.05),me-Nam 与ANGPTL8 的表达呈显著正相关(r=0.562, P=0.000)。血清BMP-4,me-Nam,ANGPTL8 及联合检测的曲线下面积分别为0.707(95%CI:0.601~0.812),0.713(95%CI:0.612~0.833),0.759(95%CI:0.667~0.850)及0.847(95%CI:0.722~0.908),联合诊断的诊断效能大于任一单一指标的诊断效能。结论 CHD 患者血清BMP-4,me-Nam 及ANGPTL8 水平升高,三者与血脂、炎症因子、冠状动脉狭窄程度及病变支数有关,检测其水平可为CHD 病情评估提供一定参考。

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备注/Memo

备注/Memo:
基金项目:2017 年度广东省医学科研基金项目(2017G0195)。
作者简介:关小明(1986-),女,本科,检验主管技师,研究方向:临床医学检验,E-mail:guanxiaoming0715@163.com。
更新日期/Last Update: 1900-01-01