[1]赵佳a,姚创利a,左林,等.冠心病患者血清同型半胱氨酸对血脂和锰超氧化物歧化酶的影响[J].现代检验医学杂志,2015,30(05):44-45.[doi:10.3969/j.issn.1671-7414.2015.05.013]
　ZHAO Jiaa,YAO Chuang-lia,ZUO Lin,et al.Effects of Homocysteine on Blood Lipid and Manganese Superoxide Dismutase in Patients with Coronary Heart Disease[J].Journal of Modern Laboratory Medicine,2015,30(05):44-45.[doi:10.3969/j.issn.1671-7414.2015.05.013]
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冠心病患者血清同型半胱氨酸对血脂和锰超氧化物歧化酶的影响()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年05期
页码:
44-45
栏目:
论著
出版日期:
2015-12-10

文章信息/Info

Title:
Effects of Homocysteine on Blood Lipid and Manganese Superoxide Dismutase in Patients with Coronary Heart Disease
作者:
赵佳1a; 姚创利1a; 左林2; 黎阳1a; 姜小建1a; 杨军乐1b; 辛渭川1c
1.西安市中心医院a.检验科；b.放射科；C.心内科，西安710003； 2.第四军医大学唐都医院放射科，西安710038
Author(s):
ZHAO Jia1a; YAO Chuang-li1a; ZUO Lin2; LI Yang1a; JIANG Xiao-jian1a; YANG Jun-le1b;  XIN Wei-chuan1c
1a.Department of Clinical Laboratory；1b.Department of Radiology； 1c.Department of Cardiology，Xi’an Central Hospital，Xi’an 710003，China；2.Department of Radiology，Tangdu Hospital of the Fourth Military Medical University，Xi’an 710038，China
关键词:
同型半胱氨酸; 冠心病; 血脂; 锰超氧化物歧化酶
分类号:
R541.4；R446.112
DOI:
10.3969/j.issn.1671-7414.2015.05.013
文献标志码:
A
摘要:
目的探讨冠心病患者血清同型半胱氨酸(Hcy)水平与血脂水平和锰超氧化物歧化酶(Mn-SOD)活性的关系。方法选取2014年3月～10月期间入住西安市中心医院的82例冠心病患者作为研究对象，应用酶法测定血清Hcy水平，应用终点法测定血清胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平，应用免疫比浊法测定血清载脂蛋白AⅠ(ApoAⅠ)和载脂蛋白B(ApoB)水平，应用比色法测定血清Mn-SOD活性，将Hcy水平与血脂水平和Mn-SOD活性进行Pearson相关分析。结果冠心病组血清Hcy水平高于对照组，差异具有统计学意义(t=3.65，P＜0.05)。冠心病组血清Hcy水平与TC，TG，HDL-C和LDL-C水平无明显相关性；冠心病组血清Hcy水平与ApoAⅠ和ApoB水平呈负相关(r=－0.276，P＜0.05；r=－0.239，P＜0.05)。冠心病组血清Hcy水平与Mn-SOD活性呈负相关(r=－0.218，P<0.05)。结论高Hcy是冠心病的危险因素之一。高Hcy可能通过影响ApoAⅠ和ApoB参与脂质的代谢和动脉粥样硬化的形成，进而促进冠心病的发生发展。高Hcy可能通过抑制Mn-SOD的活性而削弱机体抗氧化的能力，造成血管内皮细胞过氧化损伤。
Abstract:
ObjectiveTo investigate the relationship between homocysteine level and blood lipid and manganese superoxide dismutase level in patients with coronary heart disease．Methods82 patients with coronary heart disease in Xi’an Central Hospital from March to October 2014 were selected as research subjects．Homocysteine (Hcy) level was detected by enzymatic method，cholesterol (TC)，triglyceride (TG)，high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) levels were detected by end-point method，apolipoprotein AI (ApoA I) and apolipoprotein B (ApoB) levels were detected by immune turbidimetric method．Colorimeter was used to detect the serum manganese superoxide dismutase (Mn-SOD) activity．The results were analyzed using Pearson correlation analysis．ResultsCompared with the control group，the serum Hcy level in the coronary heart disease group was significantly higher，the difference was statistically significant (t=3.65，P＜0.05)．In the coronary heart disease group，there was no significant correlation between the serum Hcy level and TC，TG，HDL-C and LDL-C levels；the serum Hcy level and ApoAⅠand ApoB levels showed a negative correlation (r=－0.276，P＜0.05；r=－0.239，P＜0.05)．In the coronary heart disease group，the serum Hcy level and Mn-SOD level showed a negative correlation (r=－0.218，P<0.05)．ConclusionHyperhomocysteinemia is a risk factor for coronary heart disease．Hyperhomocysteinemia may be involved in lipid metabolism and atherosclerosis formation by influencing ApoAⅠand ApoB．Hyperhomocysteinemia may inhibit Mn-SOD activity and weaken antioxidant ability，resulting in endothelial cell peroxidation injury．

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备注/Memo

备注/Memo:
基金项目：陕西省科学技术研究发展计划项目(项目编号：2013K12-02-10)。 作者简介：赵佳(1984-)，女，博士，主管检验师，主要从事临床生物化学检验工作，E-mail：84911zj@163.com。 通讯作者：姜小建(1968-)，男，本科，主任检验师，主要从事临床医学检验工作，E-mail：jiangxiaojian1005@126.com。
更新日期/Last Update: 1900-01-01