[1]张 蕾,陈 捷,陈玉婷.冠心病并发恶性肿瘤患者Ghrelin/obestatin比值变化及意义[J].现代检验医学杂志,2016,31(04):104-106.[doi:10.3969/j.issn.16717-414.2016.04.029]
　ZHANG Lei,CHEN Jie,CHEN Yu-ting.Change and Significance of Ghrelin/Obestatin in Patients with Coronary Heart Disease Complicated with Malignant Tumor[J].Journal of Modern Laboratory Medicine,2016,31(04):104-106.[doi:10.3969/j.issn.16717-414.2016.04.029]
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冠心病并发恶性肿瘤患者Ghrelin/obestatin比值变化及意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年04期
页码:
104-106
栏目:
论著
出版日期:
2016-08-10

文章信息/Info

Title:
Change and Significance of Ghrelin/Obestatin in Patients with Coronary Heart Disease Complicated with Malignant Tumor
文章编号:
1671-7414(2016)04-104-03
作者:
张 蕾1; 陈 捷2; 陈玉婷2
1.陕西省中医医院检验科,西安 710003;
2.余姚市人民医院检验科,浙江余姚 315400
Author(s):
ZHANG Lei1; CHEN Jie2; CHEN Yu-ting2
1.Department of Clinical Laboratory, Traditional Chinese Medicine Hospital of Shaanxi Province,Xi'an 710003,China;
2.Department of Clinical Laboratory,People's Hospital of Yuyao,Zhejiang Yuyao 315400,China
关键词:
冠心病;  恶性肿瘤;  胃饥饿素/肥胖抑制素比值;  冠状动脉病变程度
分类号:
R541.4; R446.61
DOI:
10.3969/j.issn.16717-414.2016.04.029
文献标志码:
A
摘要:
目的 探讨冠心病并发恶性肿瘤患者胃饥饿素(Ghrelin)/肥胖抑制素(obestatin)比值变化及临床意义。方法 收集冠心病患者114例作为研究对象,根据是否并发恶性肿瘤分为冠心病肿瘤组(n=45)和单纯冠心病组(n=69),选择同期健康志愿者50例作为对照组。采用ELISA法测定血清Ghrelin,obestatin水平。根据冠脉造影结果采用Gensini积分评估冠脉病变程度。结果 冠心病肿瘤组、单纯冠心病组患者的Ghrelin/obestatin比值(15.1±4.8,28.3±5.4)显著低于对照组(53.4±9.3),差异均有统计学意义(t=8.537,5.736,P<0.01)。冠心病肿瘤组患者的Ghrelin/obestatin比值与Gensini积分呈负相关(r=-0.61,P<0.01)。结论 冠心病并发恶性肿瘤患者的Ghrelin/obestatin比值与冠状动脉病变程度密切相关。Ghrelin/obestatin比值在预测冠心病并发恶性肿瘤中有一定的辅助参考价值。
Abstract:
Objective To investigate the change and clinical significance of Ghrelin/obestatin in patients with coronary heart disease complicated with malignant tumor.Methods Collected 114 casesof coronary heart disease patients as research subjects,according to whether complicated with malignant tumor were divided into coronary heart disease complicated with malignant tumor group(n=45)and simple coronary heart disease group(n=69),selected the same period 50 cases of healthy volunteers as a control group.ELISA method was used to determine serum Ghrelin and obestatin levels.Gensini score was used to evaluate the extent of coronary lesions according tothe results of coronary angiography.Results The Ghrelin/obestatin ratio of coronary heart disease complicated with malignant tumor group and simple coronary heart disease group(15.1±4.8,28.3±5.4)were significantly lower than the control group(53.4±9.3),the difference were statistically significant(t=8.537,5.736,P<0.01).The Ghrelin/obestatin ratio of patients with coronary heart disease complicated with malignant tumor was negatively correlated with Gensini score(r=-0.61,P<0.01).Conclusion Ghrelin/obestatin ratio was closely related to the degree of coronary artery disease in patients with coronary heart disease complicated with malignant tumor.Ghrelin/obestatin ratio has a supplementary reference value in predicting coronary heart disease combined with malignant tumor.

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备注/Memo

备注/Memo:
基金项目:浙江省医药卫生科技计划项目(2011KYA147)。
作者简介:张 蕾(1983-),女,本科,主管技师,主要从事临床检验工作及研究,E-mail:lwtgzhanglei@163.com。
更新日期/Last Update: 2016-08-10