[1]姚创利,黎 阳,鲁旭娟,等.超氧化物歧化酶及其同工酶和超敏C-反应蛋白与冠心病的关系[J].现代检验医学杂志,2016,31(05):73-75.[doi:10.3969/j.issn.1671-7414.2016.05.019]
 YAO Chuang-li,LI Yang,LU Xu-juan,et al.Relationship of Superoxide Dismutase Isoenzyme and High Sensitive C-Reactive Protein with Coronary Heart Disease[J].Journal of Modern Laboratory Medicine,2016,31(05):73-75.[doi:10.3969/j.issn.1671-7414.2016.05.019]
点击复制

超氧化物歧化酶及其同工酶和超敏C-反应蛋白与冠心病的关系()
分享到:

《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年05期
页码:
73-75
栏目:
论著
出版日期:
2016-10-21

文章信息/Info

Title:
Relationship of Superoxide Dismutase Isoenzyme and High Sensitive C-Reactive Protein with Coronary Heart Disease
文章编号:
1671-7414(2016)05-073-03
作者:
姚创利黎 阳鲁旭娟姜小建
西安市中心医院检验科,西安 710003
Author(s):
YAO Chuang-liLI YangLU Xu-juanJIANG Xiao-jian
Department of Clinical Laboratory,Xi'an Central Hospital,Xi'an 710003,China
关键词:
冠心病 超敏C-反应蛋白 氧化物歧化酶 锰超氧化物歧化酶
分类号:
R541.4; R446.112
DOI:
10.3969/j.issn.1671-7414.2016.05.019
文献标志码:
A
摘要:
目的 探讨超氧化物歧化酶(T-SOD)及其同工酶锰超氧化物歧化酶(Mn-SOD)活性、超敏C-反应蛋白(hs-CRP)浓度变化与冠心病(CHD)的关系。方法 共81例冠心病患者及60例健康体检者参与研究,分别采用比色法和胶乳增强免疫比浊法测定被检者血清T-SOD,Mn-SOD和Hs-CRP。结果 和健康对照组相比,冠心病患者组T-SOD和Mn-SOD的活性显著降低(t=9.41,6.34,P<0.01),Hs-CRP浓度显著增高,差异有统计学意义(t=3.09,P<0.05); T-SOD,Mn-SOD活性和Hs-CRP浓度呈负相关,差异有统计学意义(P<0.01)。结论 T-SOD,Mn-SOD和Hs-CRP水平变化与冠心病的发生、发展密切相关,可作为冠心病患者危险因素评估的重要指标,联合检测分析T-SOD,Mn-SOD和hs-CRP的相关性对冠心病的临床诊治及预后有一定的指导意义。
Abstract:
Objective To investigate the relationship between the activity of superoxide dismutase(T-SOD)as well as its manganese superoxide dismutase isozyme(Mn-SOD),concentration levels of hypersensitive c-reactive protein(hs-CRP)and coronary heart disease.Methods The levels of serum T-SOD,Mn-SOD and hs-CRP were measured in 81 patients with coronary heart disease and 60 healthy controls,respectively.T-SOD was measured by colorimetricmethod and hs-CRP was measured by latex enhanced immune turbidimetric assay.Results Compered with the control group,activity of T-SOD,Mn-SOD in CHD group were significantly decreased(t=9.41,6.34,all P<0.01).However,hs-CRP in CHD group were significantly increased to those in controls(t=3.09,P<0.05).The activity of T-SOD,Mn-SOD were negatively correlated with hs-CRP(P<0.01).Conclusion The variation of T-SOD,Mn-SOD activity and hs-CRP content were closely related to the occurrence and development of CHD,they could be the impor tant indicators for riskfactors assessment of CHD.Moreover,conjointanalysis the correlation of T-SOD,Mn-SOD and hs-CRP has certain guiding significance for the clinical treatment and prognosis of coronary heart disease.

参考文献/References:

[1] Artenjak A,Lakota K,Frank M,et al.Antiphospholipid antibodiesas non-traditional risk factors in athemsclerosis based cardiovascular diseases whithout over autoimmunity.A critical updated review[J].Autoimmun Rev,2012,11(12):873-882.
[2] Zhang PY,Xu X,Li XC.Cardiovascular diseases:oxidative damage and antioxidant protection[J].European Review for Medical and Pharmacological Sciences,2014,18(20):3091-3096.
[3] Rifai N,Ridker PM.High-sensitivity C-reactive protein,a novel and promising marker of coronary heart disease[J].Clin Chem,2001,47(3):403-411.
[4] Lubrano V,Balzan S.Enzymatic antioxidant system in vascular inflammation and coronary artery disease[J].World J Exp Med,2015,5(4):218-224.
[5] 简 序,王金和,程佩兰.C反应蛋白的临床研究进展[J].国外医学:临床生物化学与检验学分册,2004,25(5):471-473. Jian X,Wang JH,Cheng PL.Clinical research progress of C-reactive protein[J].Foreign Medical Sciences:Clinical Biochemistry and Laboratory Section,2004,25(5):471-473.
[6] Marti-Carvajal AJ,Sola I,Lathyris D,et al.Homocysteine-lowering interventions for preventing cardiovascular events[J].Cochrane Database Syst Rev,2013(1):CD00 6612.
[7] Jensen MK,Wang Y,Rimm EB,et al.Fluorescent oxidation products and risk of coronary heart disease:a prospective study in women[J].J Am Heart Assoc,2013,2(5):e000195.
[8] Su X,He Y,Yang W,et al.Effect of Dan Hong injection on PON1,SOD activity and MDA levels in elderly patients with coronary heart disease[J].Int J Clin Exp Med,2014,7(12):5886-5889.
[9] Kakko S,Paivansalo M,Koistinen P,et al.The signal sequence polymorphism of the MnSOD gene is associated with the degree of carotid at herosclerosis[J].Athero-Sclerosis,2003,168(1):147-152.
[10] 姚创利,赵 佳,黎 阳,等.锰超氧化物歧化酶9 Ala/Val基因多态性对冠心病的影响[J].现代检验医学杂志,2015,30(2):1-2,6. Yao CL,Zhao J,Li Y,et al.Effects of manganese superoxide dismutase 9 Ala/val genetic polymorphisms on coronary heart disease[J].J Mod Lab Med,2015,30(2):1-2,6.
[11] Grossman AN,Opie LH,Beshansky JR,et al.Glucose-insulin-potassium revived:current status in acute coronary syndromes and the energy-depleted heart[J].Circulation,2013,127(9):1040-1048.
[12] 杨胜利,何秉贤.C-反应蛋白与冠心病[J].中华心血管病杂志,2001,29(3):187-188. Yang SL,He BX.C-reactive protein and coronary heart disease[J].ChinJ Cardiolo,2001,29(3):187-188.

相似文献/References:

[1]韩瑞玲,李 艳,吴 薇.武汉地区冠心病患者氯吡格雷药物代谢相关基因CYP2C19的多态性分布分析[J].现代检验医学杂志,2015,30(03):21.[doi:10.3969/j.issn.1671-7414.2015.03.006]
 HAN Rui-ling,LI Yan,WU Wei.Analysis of the Polymorphism Distribution of Clopidogrel Metabolism Related Gene CYP2C19 in Patients with Coronary Artery Disease in Wuhan[J].Journal of Modern Laboratory Medicine,2015,30(05):21.[doi:10.3969/j.issn.1671-7414.2015.03.006]
[2]洪骏,王锋,印中鹏,等.冠心病患者血浆纤维蛋白原与脂蛋白相关磷脂酶A2水平[J].现代检验医学杂志,2015,30(05):6.[doi:10.3969/j.issn.1671-7414.2015.05.003]
 HONG Jun,WANG Feng,YIN Zhong-peng,et al.Levels of Plasma Lipoprotein Associated Phospholipase A2 and Fibrinogen in Patients with Coronary Artery Disease[J].Journal of Modern Laboratory Medicine,2015,30(05):6.[doi:10.3969/j.issn.1671-7414.2015.05.003]
[3]赵佳a,姚创利a,左林,等.冠心病患者血清同型半胱氨酸对血脂和锰超氧化物歧化酶的影响[J].现代检验医学杂志,2015,30(05):44.[doi:10.3969/j.issn.1671-7414.2015.05.013]
 ZHAO Jiaa,YAO Chuang-lia,ZUO Lin,et al.Effects of Homocysteine on Blood Lipid and Manganese Superoxide Dismutase in Patients with Coronary Heart Disease[J].Journal of Modern Laboratory Medicine,2015,30(05):44.[doi:10.3969/j.issn.1671-7414.2015.05.013]
[4]李 垚,杨 平.早发冠心病触珠蛋白水平及其在免疫调节中的作用研究[J].现代检验医学杂志,2015,30(01):98.[doi:10.3969/j.issn.1671-7414.2015.01.027]
 LI Yao,YANG Ping.Role of Haptoglobin in the Immunomodulatory in Patients with Premature Coronary Heart Disease[J].Journal of Modern Laboratory Medicine,2015,30(05):98.[doi:10.3969/j.issn.1671-7414.2015.01.027]
[5]张 蕾,陈 捷,陈玉婷.冠心病并发恶性肿瘤患者Ghrelin/obestatin比值变化及意义[J].现代检验医学杂志,2016,31(04):104.[doi:10.3969/j.issn.16717-414.2016.04.029]
 ZHANG Lei,CHEN Jie,CHEN Yu-ting.Change and Significance of Ghrelin/Obestatin in Patients with Coronary Heart Disease Complicated with Malignant Tumor[J].Journal of Modern Laboratory Medicine,2016,31(05):104.[doi:10.3969/j.issn.16717-414.2016.04.029]
[6]赵 佳,左 林,姚创利,等.冠心病患者血清同型半胱氨酸水平与氧化应激的关系研究[J].现代检验医学杂志,2016,31(05):27.[doi:10.3969/j.issn.1671-7414.2016.05.007]
 ZHAO Jia,ZUO Lin,YAO Chuang-li,et al.Study on the Relationship between Serum Homocysteine Levels and Oxidative Stress in Patients with Coronary Heart Disease[J].Journal of Modern Laboratory Medicine,2016,31(05):27.[doi:10.3969/j.issn.1671-7414.2016.05.007]
[7]李 慧,贾良勇,冯 莉,等.阻塞性睡眠呼吸暂停低通气综合征并发脑梗死患者相关炎性指标的临床研究[J].现代检验医学杂志,2016,31(05):50.[doi:10.3969/j.issn.1671-7414.2016.05.013]
 LI Hui,JIA Liang-yong,FENG Li,et al.Clinical Studies of the Inflammatory Markers in Patients with Obstructive Sleep Apnea-Hypopnea Syndrom Complicated by Cerebral Infarction[J].Journal of Modern Laboratory Medicine,2016,31(05):50.[doi:10.3969/j.issn.1671-7414.2016.05.013]
[8]黄生金,郑利平,陆俊佳,等.广西地区壮族和汉族冠心病患者胱抑素C水平及其基因多态性的比较研究[J].现代检验医学杂志,2017,32(03):26.[doi:10.3969/j.issn.1671-7414.2017.03.007]
 HUANG Sheng-jin,ZHENG Li-ping,LU Jun-jia,et al.Comparative Study of Cystatin C and Its Gene Polymorphism of Pati ents with Coronary Heart Disease between Zhuang and Han in Guangxi Region[J].Journal of Modern Laboratory Medicine,2017,32(05):26.[doi:10.3969/j.issn.1671-7414.2017.03.007]
[9]王跃帮,吴 娟,崔 倩,等.IL-6基因启动子区域-572C>G和-174G>C多态性与江苏宿迁汉族人群冠心病的相关性[J].现代检验医学杂志,2018,33(03):31.[doi:10.3969/j.issn.1671-7414.2018.03.010]
 WANG Yue-bang,WU Juan,CUI Qian,et al.Association between Interleukin-6-572C>G and -174G>C Gene Polymorphism in the Promoter Region and Coronary Heart Disease of Han Population in Suqian of Jiangsu[J].Journal of Modern Laboratory Medicine,2018,33(05):31.[doi:10.3969/j.issn.1671-7414.2018.03.010]
[10]刘亚东,冯莉莉,王海晶,等.冠心病患者血清Lp-PLA2与HCY检测及其与冠状动脉病变程度的相关性分析[J].现代检验医学杂志,2018,33(06):83.[doi:10.3969/j.issn.1671-7414.2018.06.022]
 LIU Ya-dong,FENG Li-li,WANG Hai-jing,et al.Detection of Serum Lp-PLA2 and HCY in Patients with Coronary Heart Disease and Its Correlation with the Degree of Coronary Artery Disease[J].Journal of Modern Laboratory Medicine,2018,33(05):83.[doi:10.3969/j.issn.1671-7414.2018.06.022]

备注/Memo

备注/Memo:
基金项目:陕西省科学技术研究发展计划项目(项目编号:2013K12-02-10)。
作者简介:姚创利(1962-),男,本科,副主任检验师,主要从事临床生物化学检验工作,E-mail:yaocl7270@163.com。
通讯作者:鲁旭娟(1966-),女,本科,主管检验师,E-mail:1323878654@qq.com。
更新日期/Last Update: 2016-10-30