[1]王 旋,崔立春,党升强.非小细胞肺癌放化疗联合靶向治疗对血清肿瘤标志物、免疫功能及CyclinD3水平影响的相关研究[J].现代检验医学杂志,2021,36(04):25-30.[doi:10.3969/j.issn.1671-7414.2021.04.006]
 WANG Xuan,CUI Li-chun,DANG Sheng-qiang.Effects of Radiotherapy and Chemotherapy Combined with Targeted Therapy onSerum Tumor Markers, Immune Function and CyclinD3 Level inNon-Small Cell Lung Cancer[J].Journal of Modern Laboratory Medicine,2021,36(04):25-30.[doi:10.3969/j.issn.1671-7414.2021.04.006]
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非小细胞肺癌放化疗联合靶向治疗对血清肿瘤标志物、免疫功能及CyclinD3水平影响的相关研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年04期
页码:
25-30
栏目:
论 著
出版日期:
2021-07-31

文章信息/Info

Title:
Effects of Radiotherapy and Chemotherapy Combined with Targeted Therapy onSerum Tumor Markers, Immune Function and CyclinD3 Level inNon-Small Cell Lung Cancer
文章编号:
1671-7414(2021)04-025-06
作者:
王 旋崔立春党升强
(长安医院肿瘤科,西安 710016)
Author(s):
WANG Xuan CUI Li-chun DANG Sheng-qiang
(Department of Oncology, Chang’an Hospital, Xi’an 710016,China)
关键词:
放化疗 非小细胞肺癌 肿瘤标志物 免疫功能 细胞周期蛋白D3
分类号:
R734.2;R730.43
DOI:
10.3969/j.issn.1671-7414.2021.04.006
文献标志码:
A
摘要:
目的 观察非小细胞肺癌放化疗联合靶向治疗对血清肿瘤标志物、免疫功能及细胞周期蛋白D3(Cyclin D3) 水平的影响。方法 以2014 年6 月~2017 年1 月长安医院收治的136 例非小细胞肺癌病例为前瞻性研究对象,按照巢式病例对照法分组,将接受放化疗联合靶向治疗的非小细胞肺癌病例纳入放化疗联合靶向组( 共68 例) 和单纯放化疗组( 共68 例)。分析放化疗联合靶向组和单纯放化疗组的疗效评价指标和血清病情相关指标( 肿瘤标志物、免疫功能指标及Cyclin D3) 的差异。结果 放化疗联合靶向组的无疾病进展生存时间(6.1±1.2 月) 长于单纯放化疗组 (4.8±0.9 月),差异具有统计学意义(95% CI: 3.880~8.781,t= 6.563,P=0.003)。放化疗联合靶向组平均总生存时间(13.6±1.8 月) 长于单纯放化疗组(11.3±1.4 月),差异具有统计学意义(95% CI: 2.674~12.429,t=7.639,P=0.019)。非小细胞肺癌标志物(CA125,CA153,TRIM59,COX,CEA,cyfra21-1,SCC) 及Cyclin D3 表达显示:与治疗前比较,治疗后放化疗联合靶向组和单纯放化疗组肿瘤标志物均下降,但放化疗联合靶向组标志物下降幅度高于单纯放化疗组,经t 检验比较差异具有统计学意义(t=14.814~26.492,均P<0.05)。T 细胞亚群指标(CD3+,CD4+,CD4+/CD8+) 和免疫球蛋白指标(IgG,IgA,IgM)数据显示:与治疗前比较,治疗后放化疗联合靶向组和单纯放化疗组的T 细胞亚群指标和免疫球蛋白指标均提升,但放化疗联合靶向组标志物提升幅度高于单纯放化疗组,经t 检验比较差异具有统计学意义(t=11.617~26.384,均P<0.05)。结论 与单纯放化疗方案相比,放化疗联合靶向治疗治疗非小细胞肺癌并未出现更多临床不良反应,同时也可改善肿瘤标志物、免疫功能及Cyclin D3 等病情相关指标表达,使其获得更长的无疾病进展生存时间、总生存时间的临床收益。

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备注/Memo

备注/Memo:
基金项目:国家自然基金(项目编号:81460356)。
作者简介:王旋(1980-),男,本科,主治医师, 研究方向:癌症放化疗,靶向治疗及免疫治疗,E-mail:1275224257@qq.com。
更新日期/Last Update: 1900-01-01