[1]陈　颖,王伟佳,胡　婷,等.急性胰腺炎患者血清C1q补体水平与疾病严重程度的相关性研究[J].现代检验医学杂志,2021,36(04):45-50.[doi:10.3969/j.issn.1671-7414.2021.04.010]
　CHEN Ying,WANG Wei-jia,HU Ting,et al.Research on Relevant Serum C1q Complement Level inthe Severity of Acute Pancreatitis[J].Journal of Modern Laboratory Medicine,2021,36(04):45-50.[doi:10.3969/j.issn.1671-7414.2021.04.010]
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急性胰腺炎患者血清C1q补体水平与疾病严重程度的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年04期
页码:
45-50
栏目:
论　著
出版日期:
2021-07-31

文章信息/Info

Title:
Research on Relevant Serum C1q Complement Level inthe Severity of Acute Pancreatitis
文章编号:
1671-7414（2021）04-045-06
作者:
陈　颖; 王伟佳; 胡　婷; 黄福达; 缪丽韶; 唐　凤; 罗楚君
（中山大学附属中山医院检验医学中心，广东中山 528403）
Author(s):
CHEN Ying;  WANG Wei-jia;  HU Ting;  HUANG Fu-da;  MIU Li-shao;  TANG Feng;  LUO Chu-jun
(Department of Laboratory Diagnosis,Zhongshan Hospital Affiliated to Sun Yat-sen University,Guangdong Zhongshan 528403,China）
关键词:
急性胰腺炎; 补体C1q ; 超敏C 反应蛋白
分类号:
R576；R446.62
DOI:
10.3969/j.issn.1671-7414.2021.04.010
文献标志码:
A
摘要:
目的　分析急性胰腺炎（acute pancreatitis，AP) 患者血清补体1q（C1q）水平的变化，探讨C1q 诊断及预测AP 患者严重程度的临床价值。方法　选取2019 年11 月~2020 年10 月中山大学附属中山医院收治AP 患者104 例，分为轻症AP（MAP）47 例、中度重症AP（MSAP）32 例和重症AP（SAP）25 例；对照组选自同期52 例健康体检者。检测各组血清C1q 水平，同时检测三酰甘油（TG）和超敏C 反应蛋白（hs-CRP) 等生化指标，比较各组之间的差异；使用逐步多元线性回归分析各因素对C1q 水平的影响。采用ROC 曲线及曲线下面积（AUC) 探讨C1q 诊断AP 患者及预测严重程度的有效性。结果　AP 患者血清C1q 水平显著低于对照组，差异有统计学意义（t=-8.317，P ＜ 0.05）；与MAP 组和MSAP 组相比，SAP 组血清C1q 水平显著降低，差异均有统计学意义（t=5.624 和4.132，均P ＜ 0.05）；MAP 组和MSAP 组血清C1q 水平相比，差异无统计学意义（t=1.528，P=0.132）。校正了年龄、性别、病史、病因及hs-CRP 等其他生化指标的影响后，AP 患者血清C1q 水平与急性生理学与慢性健康状况评分系统Ⅱ（APACHE Ⅱ评分）（β=-0.587，P ＜ 0.05）与hs-CRP（β=-0.279，P ＜ 0.05）有关。ROC 显示血清C1q 诊断AP 患者的AUC 为0.854，取诊断界限值为 224.40μg/ml 时，敏感度和特异度分别为78.85%，88.46%。血清C1q 诊断SAP 患者时AUC 为0.822，取诊断界限值为203.56μg/ml 时，敏感度为80.00%，特异度为82.28%；APACHE Ⅱ评分诊断SAP 效能优于C1q，差异有统计学意义（Z=2.975，P=0.003)；用二元Logistic 回归求出C1q 和hs-CRP 联合诊断SAP 的预测概率值，AUC 为0.926,敏感度、特异度分别为84.00% 和88.61%，与APACHE Ⅱ评分诊断SAP 相比，二者之间差异无统计学意义（Z=0.582，P=0.560)。结论　AP 患者血清C1q 水平明显降低，可作为AP 及SAP 诊断的潜在指标；C1q 和hs-CRP 联合检测可能是SAP 诊断及预测较好的实验室检测指标。

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备注/Memo

备注/Memo:
基金项目：中山市医学科研基金项目(2016J008)。
作者简介：陈颖（1983-），女，硕士, 主管技师，研究方向：临床检验诊断学，E-mail：chenying2007@163.com。通信作者：王伟佳（1981-），男，博士，主任技师，硕士研究生导师, E-mail：wwj0760@163.com。
更新日期/Last Update: 1900-01-01