[1]陈志勇a,罗世林a,张 健b,等.慢阻肺患者血清IL-17,IL-27和IL-33水平表达及与不同临床分期FeNO和肺功能的相关性研究[J].现代检验医学杂志,2021,36(04):152-155.[doi:10.3969/j.issn.1671-7414.2021.04.033]
 CHEN Zhi-yonga,LUO Shi-lina,ZHANG Jianb,et al.Expression of Serum IL-17, IL-27 and IL-33 in Patients with ChronicObstructive Pulmonary Disease and Its Correlation with FeNO and LungFunction in Different Clinical Stages[J].Journal of Modern Laboratory Medicine,2021,36(04):152-155.[doi:10.3969/j.issn.1671-7414.2021.04.033]
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慢阻肺患者血清IL-17,IL-27和IL-33水平表达及与不同临床分期FeNO和肺功能的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年04期
页码:
152-155
栏目:
检验与临床
出版日期:
2021-07-31

文章信息/Info

Title:
Expression of Serum IL-17, IL-27 and IL-33 in Patients with ChronicObstructive Pulmonary Disease and Its Correlation with FeNO and LungFunction in Different Clinical Stages
文章编号:
1671-7414(2021)04-152-05
作者:
陈志勇a罗世林a张 健b蔡 懿a黎必亮a向绍山a胡小英a
(巴中市中心医院 a. 呼吸与危重症医学科;b. 检验科,四川巴中 636600)
Author(s):
CHEN Zhi-yonga LUO Shi-lina ZHANG Jianb CAI Yia LI Bi-lianga XIANG Shao-shana HU Xiao-yinga
(a.Department of Respiratory and Critical Care Medicine;b. Department of Laboratory Medicine, Bazhong CentralHospital, Sichuan Bazhong 636600,China)
关键词:
慢性阻塞性肺疾病白细胞介素-17白细胞介素-27白细胞介素-33呼出气一氧化氮肺功能
分类号:
R563;R392.11
DOI:
10.3969/j.issn.1671-7414.2021.04.033
文献标志码:
A
摘要:
目的 探讨慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD) 患者血清IL-17,IL-27 和IL-33表达水平与不同临床分期肺功能指标第一秒用力呼气容积占预计值的百分比(forced expiratory volume/predictedvalue,FEV1%pred)及呼出气一氧化氮(FeNO)的相关性。方法 收集100 例COPD 患者,分为稳定期COPD 患者(n=50)和急性加重期COPD 患者(n=50),同时收集健康者(n=40) 为正常组。测定各组血清白介素-17(interleukin-17,IL-17),白介素-27(interleukin-27,IL-27)和白介素-33(interleukin-33,IL-33)的表达水平;应用FeNO 检测仪测定FeNO 水平;应用肺功能仪检查各组肺功能指标FEV1%pred;分析血清IL-17,IL-27 和IL-33 表达水平与FEV1%pred 和FeNO的相关性。结果 COPD 组FeNO 及血清IL-17,IL-27,IL-33 的表达水平高于正常组,COPD 急性加重期组的血清IL-17,IL-27,IL-33 及FeNO 的表达水平高于稳定期组,差异有统计学意义(F=15.275,18.429,24.716 和31.143,均P<0.05)。COPD 组FEV1%pred 低于正常组,慢阻肺急性加重期组FEV1%pred 低于COPD 稳定期组,差异有统计学意义(F=724.642,P < 0.05);COPD 患者血清中IL-17,IL-27 和IL-33 表达水平与FEV1%pred 呈负相关(r=-0.682,0.743 和-0.718,均P < 0.05),与FeNO 呈正相关(r=0.685,0.714 和0.695,均P < 0.05);COPD 急性加重期组与稳定期组患者血清IL-17 与IL-27,IL-33 水平呈正相关(r=0.636 ~ 0.846,均P < 0.05);正常组血清IL-17 与IL-27及IL-33 无明显相关性(r=-0.237,-0.283,均P > 0.05)。结论 血清IL-17,IL-27 和IL-33 均参与了COPD 的发病过程, 可作为评价COPD 的有效指标。

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备注/Memo

备注/Memo:
作者简介:陈志勇(1988-),男,本科,主治医师,研究方向:肺癌及呼吸危重症,E-mail:tfwy567@163.com。通信作者:胡小英(1990-),女,本科,主治医师。研究方向:呼吸危重症,E-mail:hxyns123@163.com。
更新日期/Last Update: 1900-01-01