[1]梁 佐,仝志强,岳振华,等.ctDNA 检测在非小细胞肺癌临床诊疗应用中的最新研究进展[J].现代检验医学杂志,2024,39(02):192-197.[doi:10.3969/j.issn.1671-7414.2024.02.035]
 LIANG Zuo,TONG Zhiqiang,YUE Zhenhua,et al.Latest Research Progress in ctDNA Detection for Clinical Diagnosis and Treatment of Non-Small Cell Lung Cancer[J].Journal of Modern Laboratory Medicine,2024,39(02):192-197.[doi:10.3969/j.issn.1671-7414.2024.02.035]
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ctDNA 检测在非小细胞肺癌临床诊疗应用中的最新研究进展()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第39卷
期数:
2024年02期
页码:
192-197
栏目:
综述
出版日期:
2024-03-31

文章信息/Info

Title:
Latest Research Progress in ctDNA Detection for Clinical Diagnosis and Treatment of Non-Small Cell Lung Cancer
文章编号:
1671-7414(2024)02-192-06
作者:
梁 佐1仝志强2岳振华1白晓鸣2
(1. 山西医科大学第五临床医学院,太原 030012;2. 山西省人民医院,太原 030012)
Author(s):
LIANG Zuo1 TONG Zhiqiang2 YUE Zhenhua1 BAI Xiaoming2
(1.the Fifth Clinical Medical College of Shanxi Medical University, Taiyuan 030012, China;2.Shanxi Provincial People’s Hospital, Taiyuan 030012,China)
关键词:
非小细胞肺癌液态活检循环肿瘤DNA
分类号:
R734.2;R730.43
DOI:
10.3969/j.issn.1671-7414.2024.02.035
文献标志码:
A
摘要:
非小细胞肺癌(non-small cell lung cancer,NSCLC)是一种高度致死性的恶性肿瘤,给人类健康带来严重威胁。传统的肿瘤诊疗方法存在许多局限性,而液体活检技术中的循环肿瘤DNA(circulating tumor DNA,ctDNA)检测由于其无创便捷、全面灵敏的特点,在NSCLC 的个体化治疗和监测中引起了广泛关注。该文将综述近年来ctDNA 检测在NSCLC 临床诊疗应用中的最新研究进展,包括其在早期筛查、疾病诊断、肿瘤突变监测、治疗效果评估以及预后评估等方面的应用。
Abstract:
Non-small cell lung cancer (NSCLC) is a highly lethal malignant tumor that poses a serious threat to human health. Traditional methods for tumor diagnosis and treatment have many limitations. However, circulating tumor DNA (ctDNA) detection, a kind of liquid biopsy technology, has gained widespread attention in the field of NSCLC personalized therapy and monitoring due to its non-invasive, convenient, and comprehensive sensitivity. This article will review the latest research progress of ctDNA detection in the clinical diagnosis and treatment of NSCLC in recent years, including its applications in early screening, disease diagnosis, tumor mutation monitoring, treatment efficacy evaluation, and prognosis assessment.

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备注/Memo

备注/Memo:
作者简介:梁佐(1998-),男,硕士研究生在读,研究方向:胸心外科临床与基础研究,E-mail:13803437795@163.com。
通讯作者: 白晓鸣(1964-),男,硕士研究生,主任医师,研究方向:胸外科肺癌,食管癌及纵隔疾病诊治,E-mail: 13803437795@163.com。
更新日期/Last Update: 2024-03-15