[1]申 旺,杨文丽,叶丽燕,等.血清唾液酸在原发性肝癌和转移性肝癌诊断中的临床价值[J].现代检验医学杂志,2015,30(01):140-142.[doi:10.3969/j.issn.1671-7414.2015.01.042]
　SHEN Wang,YANG Wen-li,YE Li-yan,et al.Clinical Value of Serum Sialic Acid Detection for Diagnosis in Primary Hepatic Carcinoma and Metastatic Hepatic Carcinoma[J].Journal of Modern Laboratory Medicine,2015,30(01):140-142.[doi:10.3969/j.issn.1671-7414.2015.01.042]
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血清唾液酸在原发性肝癌和转移性肝癌诊断中的临床价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年01期
页码:
140-142
栏目:
检验与临床
出版日期:
2015-01-30

文章信息/Info

Title:
Clinical Value of Serum Sialic Acid Detection for Diagnosis in Primary Hepatic Carcinoma and Metastatic Hepatic Carcinoma
文章编号:
1671-7414(2015)01-140-03
作者:
申 旺1; 杨文丽2; 叶丽燕1; 黄晨娟1; 李月桂1
1.江门市五邑中医院检验科,广东江门 529000;
2.江门市中心医院病理科,广东江门 529030
Author(s):
SHEN Wang1; YANG Wen-li2; YE Li-yan1; HUANG Chen-juan1; LI Yue-gui1
1.Department of Clinical Laboratory,Wuyi Traditional Chinese Medicine Hospital, Guangdong Jiangmen 529000,China;
2.Department of Pathology, Jiangmen Central Hospital,Guangdong Jiangmen 529030,China
关键词:
唾液酸;  甲胎蛋白;  原发性肝癌;  转移性肝癌
分类号:
R735.7; R730.43
DOI:
10.3969/j.issn.1671-7414.2015.01.042
文献标志码:
A
摘要:
目的 探讨血清唾液酸(SA)在原发性肝癌(PHC)和转移性肝癌(MHC)中诊断及其鉴别诊断的临床价值。方法 以2012年1月～2014年6月期间五邑中医院确诊的100例PHC患者,91例MHC患者,155例肝良性疾病患者和139例健康体检者为研究对象,分别采用化学酶法和化学发光法检测血清SA和甲胎蛋白(AFP)水平,结果采用SPSS19.0进行统计分析。结果 PHC组血清SA水平(701.08±189.33 mg/L)明显高于肝良性疾病组(588.38±98.51 mg/L)和健康人群组(572.37±89.13 mg/L),差异有统计学意义(P均=0.000); MHC组的血清SA水平(790.20±162.29 mg/L)与PHC组比较,差异也有统计学意义(P=0.027); 血清SA诊断MHC的敏感度84.6%,特异度85.2%和曲线下面积(AUC)0.895显著高于血清AFP(敏感度22.2%,特异度29.6%和AUC 0.301),差异均有统计学意义(P均=0.000)。结论 血清SA在PHC和MHC的诊断及其鉴别诊断中均具有重要的临床价值。
Abstract:
Objective To study the diagnostic and distinguishing diagnostic value in primary hepatic carcinoma(PHC)and metastatic hepaticcarcinoma(MHC)by the serum sialic acid(SA)detection.Methods During January 2012 to June 2014,100 cases of patients with PHC,91 cases of patients with MHC,155 cases of benign liver disease patients,and 139 healthy people in Wuyi Traditional Chinese Medicine Hospital were included into the study.The concentration of serum SA and AFP were detected by chemical enzymatic method and chemiluminescence method,SPSS19.0 was used to analysis the results.Results The concentration of serum SA in PHC patients(701.08±189.33 mg/L)were significantly higher than benign liver disease patients(588.38±98.51 mg/L)and healthy people(572.37±89.13 mg/L),there was statistical significance(P=0.000),the significantly statistical differences were also in MHC(790.20±162.29 mg/L)and PHC patients(P=0.027).Serum SA in the diagnosis of MHC sensitivity,specificity and AUC were 84.6%,85.2% and 0.895,compared with serum AFP(sensitivity 22.2%,specificity 29.6%and AUC 0.301)had statistically significance(P=0.000).Conclusion The serum SA has important clinical significance in the diagnosis and distinguishing diagnosis of PHC and MHC.

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备注/Memo

备注/Memo:

作者简介:申 旺(1983-),男,本科,主管检验技师,主要研究方向为生化和免疫发光,Tel:13750396920,E-mail:shenwang11@163.com。
更新日期/Last Update: 2015-01-30