[1]姚创利,赵 佳,黎 阳,等.锰超氧化物歧化酶9 Ala/Val基因多态性对冠心病的影响[J].现代检验医学杂志,2015,30(02):1-2,6.[doi:10.3969/j.issn.1671-7414.2015.02.001]
　YAO Chuang-li,ZHAO Jia,LI Yang,et al.Effects of Manganese Superoxide Dismutase 9 Ala/Val Genetic Polymorphisms on Coronary Heart Disease[J].Journal of Modern Laboratory Medicine,2015,30(02):1-2,6.[doi:10.3969/j.issn.1671-7414.2015.02.001]
点击复制

锰超氧化物歧化酶9 Ala/Val基因多态性对冠心病的影响()

《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年02期
页码:
1-2,6
栏目:
论著
出版日期:
2015-03-20

文章信息/Info

Title:
Effects of Manganese Superoxide Dismutase 9 Ala/Val Genetic Polymorphisms on Coronary Heart Disease
作者:
姚创利a,赵 佳a,黎 阳a,黎 波a,陆 华a,白 妮a,刘 琳a,辛渭川b,姜小建a
西安市中心医院 a.检验科; b.心内科,西安 710003
Author(s):
YAO Chuang-lia,ZHAO Jiaa,LI Yanga,LI Boa,LU Huaa,BAI Nia,LIU Lina,XIN Wei-chuanb, JIANG Xiao-jiana
a.Department of Clinical Laboratory; b.Department of Cardiology,Xi'an Central Hospital,Xi'an 710003,China
关键词:
锰超氧化物歧化酶;  冠心病;  基因多态性
分类号:
R541.4; Q781
DOI:
10.3969/j.issn.1671-7414.2015.02.001
文献标志码:
A
摘要:
目的 研究锰超氧化物歧化酶(Mn-SOD)9 Ala/Val基因多态性与T-SOD和Mn-SOD活性的关系以及对冠心病(CHD)的影响。方法 共82例冠心病患者和57例正常人参与研究,应用测序法检测两组的Mn-SOD 9 Ala/Val基因多态性的基因型,应用比色法检测两组的血清T-SOD和Mn-SOD活性。结果 冠心病组的血清T-SOD和Mn-SOD活性低于对照组(t=4.83,6.57,P均<0.05),冠心病组的Mn-SOD 9 VV基因型和V等位基因频率高于对照组(χ2=4.75,P<0.05),Mn-SOD 9 VV基因型的血清T-SOD和Mn-SOD活性低于Mn-SOD 9 AA基因型(t=2.96,3.11,P均<0.05)。结论 冠心病患者的血清T-SOD和Mn-SOD活性降低,Mn-SOD 9 Ala/Val基因多态性通过影响Mn-SOD的活性进而参与冠心病的发病。
Abstract:
Objective To study associations between manganese superoxide dismutase 9 Ala/Val(Mn-SOD 9 Ala/Val)genetic polymorphism and total superoxide dismutase(T-SOD)and Mn-SOD activity and the impact on coronary heart disease(CHD)were studied.Methods There were 82 CHD patients and 57 controls in this research.Sequencer was used to identifythe genotype of Mn-SOD 9 Ala/Val genetic polymorphism and colorimeter was usedto detect the serum T-SOD and Mn-SOD activity.Results Compared with the control group, the serum T-SOD and Mn-SOD activity of the CHD group was significantly reduced(t=4.83,6.57,P all<0.05),while theVV genotype and V allele of Mn-SOD 9 Ala/Val genetic polymorphism of the CHD group were higher(χ2=4.75,P<0.05).The serum T-SOD and Mn-SOD activity of the Mn-SOD 9 VV genotype was significantly lower than the Mn-SOD 9 AA genotype(t=2.96,3.11,P all<0.05).Conclusion Theserum T-SOD and Mn-SOD activity in the CHD patients was reduced.Mn-SOD 9 Ala/Val genetic polymorphism was involved in the pathogenesis of CHD by influencingthe Mn-SOD activity.

参考文献/References:

[1] 杨茂平,叶林秀,邱 红,等.锰超氧化物歧化酶9 Ala/Val基因多态性与冠心病的关系[J].武汉大学学报(医学版),2008,29(6):775-779. Yang MP,Ye LX,Qiu H,et al.Association between manganese superoxide dismutase 9 Ala/Val genetic polymorphisms and coronary heart disease[J].Medical Journal of Wuhan University,2008,29(6):775-779.
[2] 迟东升,凌文华,马 静,等.Mn-SOD 9 Ala/Val基因多态性与冠心病的关系[J].中国公共卫生,2006,22(9):1078-1080. Chi DS,Ling WH,Ma J,et al.Association between manganese superoxide dismutase(MnSOD)9 Ala/Val genetic polymorphisms and coronary artery disease[J].Chinese Journal of Public Health,2006,22(9):1078-1080.
[3] Kotur-Stevuljevic J,Memon L,Stefanovic A,et al.Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients[J].Clin Biochem,2007,40(3/4):181-187.
[4] 肖 骅,雷 寒,覃 数,等.增强型体外反搏对冠心病患者血清一氧化氮、丙二醛和超氧化物歧化酶的影响[J].重庆医科大学学报,2008,33(1):60-62. Xiao H,Lei H,Tan S,et al.Effect of enhanced external counterpulsation on serum nitric oxide,malondialdehyde and superoxide dismutase in patients with coronary heart disease[J].Journal of Chongqing Medical University,2008,33(1):60-62.
[5] Mladenka P,Simunek T,Hubl M,et al.The role of reactive oxygen and nitrogen species in cellular iron metabolism[J].Free Radic Res,2006,40(3):263-272.
[6] Radi R,Cassina A,Hodara R,et al.Peroxynitrite reactions and formationin mitochondria[J].Free Radic Biol Med,2002,33(11):1451-1464.
[7] Levine AJ,Elkhouly E,Diep AT,et al.The MnSOD A16V mitochondrial targeting sequence polymorphism is not associated with increased risk of distal colorectal adenomas:data from a sigmoidoscopy-based case control study[J].CancerEpidemiol Biomarkers Prev,2002,11(10 Pt 1):1140-1141.
[8] Yen JH,Chen CJ,Tsai WC,et al.Manganese superoxide dismutase and cytochrome P450 1A1 genes polymorphisms in rheumatoid arthritis in Taiwan[J].Hum Immunol,2003,64(3):366-373.

相似文献/References:

[1]程俊杰,李 静,梁西强,等.非高密度脂蛋白胆固醇 与冠心病患者心功能分级的相关性研究[J].现代检验医学杂志,2016,31(03):43.[doi:10.3969/j.issn.1671-7414.2016.03.012]
　CHENG Jun-jie,LI Jing,LIANG Xi-qiang,et al.Correlation between Non High Density Lipoprotein Cholesterol and Cardiac Function in Patients with Coronary Heart Disease[J].Journal of Modern Laboratory Medicine,2016,31(02):43.[doi:10.3969/j.issn.1671-7414.2016.03.012]
[2]张阳东,陈 洁,楚瑞雪,等.冠心病患者α-内收蛋白基因多态性与表达水平研究[J].现代检验医学杂志,2016,31(03):59.[doi:10.3969/j.issn.1671-7414.2016.03.016]
　ZHANG Yang-dong,CHEN Jie,CHU Rui-xue,et al.Study on Polymorphisms and Genes Expression Levels of α-Adducin in Patients with Coronary Artery Disease[J].Journal of Modern Laboratory Medicine,2016,31(02):59.[doi:10.3969/j.issn.1671-7414.2016.03.016]
[3]刘运端,林世恒.脂联素及其基因多态性与广西瑶族冠心病的关系[J].现代检验医学杂志,2015,30(04):56.[doi:10.3969/j.issn.1671-7414.2015.04.015]
　LIU Yun-duan,LIN Shi-heng.Study on Relations between Adiponectin and Its Gene Polymorphism and Yao Coronary Heart Disease of Guangxi District[J].Journal of Modern Laboratory Medicine,2015,30(02):56.[doi:10.3969/j.issn.1671-7414.2015.04.015]
[4]赵佳,姚创利,左林,等.冠心病患者血清同型半胱氨酸对血脂和锰超氧化物歧化酶的影响[J].现代检验医学杂志,2015,30(05):44.[doi:10.3969/j.issn.1671-7414.2015.05.013]
　ZHAO Jiaa,YAO Chuang-lia,ZUO Lin,et al.Effects of Homocysteine on Blood Lipid and Manganese Superoxide Dismutase in Patients with Coronary Heart Disease[J].Journal of Modern Laboratory Medicine,2015,30(02):44.[doi:10.3969/j.issn.1671-7414.2015.05.013]
[5]姚创利,赵 佳,鲁旭娟,等.冠心病患者血清脂蛋白相关磷脂酶A2水平与锰超氧化物歧化酶9 Ala/Val基因多态性关系探讨[J].现代检验医学杂志,2017,32(01):26.[doi:10.3969/j.issn.1671-7414.2017.01.008]
　YAO Chuang-li,ZHAO Ja,LU Xu-juan,et al.Study on the Relationship between Lipoprotein Associated Phospholipase A2 Level and Manganese Superoxide Dismutase 9 Ala/Val Genetic Polymorphism in Patients with Coronary Heart Disease[J].Journal of Modern Laboratory Medicine,2017,32(02):26.[doi:10.3969/j.issn.1671-7414.2017.01.008]
[6]张阳东,周建荣,楚瑞雪,等.血管紧张素Ⅱ1型受体3个单核苷酸多态性与冠心病的相关性分析[J].现代检验医学杂志,2017,32(02):57.[doi:10.3969/j.issn.1671-7414.2017.02.015]
　ZHANG Yang-dong,ZHOU Jian-rong,CHU Rui-xue,et al.Correlation between the Three Single Nucleotide Polymorphisms in Angiotensin Ⅱ Type one Receptor Gene and Coronary Artery Disease[J].Journal of Modern Laboratory Medicine,2017,32(02):57.[doi:10.3969/j.issn.1671-7414.2017.02.015]
[7]刘夏炎,余安运,于佩方,等.RDW,HCY和LP(a在高血压及冠心病中的临床应用[J].现代检验医学杂志,2017,32(04):80.[doi:10.3969/j.issn.1671-7414.2017.04.022]
　LIU Xia-yan,YU An-yun,YU Pei-fang,et al.Clinical Application of RDW,HCY and LP(a)in High Blood Pressure and Combined Coronary Heart Disease[J].Journal of Modern Laboratory Medicine,2017,32(02):80.[doi:10.3969/j.issn.1671-7414.2017.04.022]
[8]阿地拉·阿布里孜,刘 敏.miR-126在血液透析并发冠心病患者中检测的临床意义[J].现代检验医学杂志,2017,32(05):97.[doi:10.3969/j.issn.1671-7414.2017.05.017]
　ADILA·Abulizi,LIU Min.Clinical Significance of Detecting miR-126 in Hemodialysis with Coronary Artery Disease[J].Journal of Modern Laboratory Medicine,2017,32(02):97.[doi:10.3969/j.issn.1671-7414.2017.05.017]
[9]张阳东,周建荣,楚瑞雪,等.PECAM-1基因rs7503550位点多态性和表达水平与冠心病及2型糖尿病的相关性研究[J].现代检验医学杂志,2019,34(03):21.[doi:10.3969/j.issn.1671-7414.2019.03.005]
　ZHANG Yang-dong,ZHOU Jian-rong,CHU Rui-xue,et al.Relativity Study on rs7503550 Polymorphism and Genes Expression Levelsof PECAM-1 in Coronary Artery Disease and Type 2 Diabetes Mellitus[J].Journal of Modern Laboratory Medicine,2019,34(02):21.[doi:10.3969/j.issn.1671-7414.2019.03.005]
[10]朱志远,王海燕,吴 波,等.冠心病患者血小板和淋巴细胞比值与冠脉斑块稳定性及预后的相关性[J].现代检验医学杂志,2019,34(04):112.[doi:10.3969/j.issn.1671-7414.2019.04.027]
　ZHU Zhi-yuan,WANG Hai-yan,WU Bo,et al.Correlation between Ratio of Platelet to Lymphocyte with the Stability of Coronary Artery Plaque and Prognosis in Patients with Coronary Heart Disease[J].Journal of Modern Laboratory Medicine,2019,34(02):112.[doi:10.3969/j.issn.1671-7414.2019.04.027]
[11]赵 佳,左 林,姚创利,等.锰超氧化物歧化酶基因变异 与血脂和同型半胱氨酸水平的关系研究[J].现代检验医学杂志,2016,31(03):12.[doi:10.3969/j.issn.1671-7414.2016.03.004]
　ZHAO Jia,ZUO Lin,YAO Chuang-li,et al.Study on the Relationship between Manganese Superoxide Dismutase Gene Variants and the Levels of Blood Lipid and Homocysteine[J].Journal of Modern Laboratory Medicine,2016,31(02):12.[doi:10.3969/j.issn.1671-7414.2016.03.004]

备注/Memo

备注/Memo:
基金项目:陕西省科学技术研究发展计划项目(项目编号2013K12-02-10)。 作者简介:姚创利(1962-),男,本科,副主任检验师,主要从事临床生物化学检验工作,E-mail: yaocl7270@163.com。 通讯作者:姜小建(1968-),男,本科,主任检验师,主要从事临床医学检验工作,E-mail:jiangxiaojian1005@126.com。
更新日期/Last Update: 2015-03-20