[1]张红雨,马兴璇.联合检测D-二聚体和CA153在乳腺癌诊治中的临床意义[J].现代检验医学杂志,2015,30(02):137-138.[doi:10.3969/j.issn.1671-7414.2015.02.043]
点击复制

联合检测D-二聚体和CA153在乳腺癌诊治中的临床意义()
分享到:

《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年02期
页码:
137-138
栏目:
检验与临床
出版日期:
2015-03-20

文章信息/Info

作者:
张红雨马兴璇
柳州市中医院检验科,广西柳州 545001
关键词:
D-二聚体 糖类抗原153 乳腺癌 联合检测
分类号:
R737.9; R730.43
DOI:
10.3969/j.issn.1671-7414.2015.02.043
文献标志码:
A
摘要:
目的 探讨D-二聚体和糖类抗原153(CA153)联合检测在乳腺癌诊治中的临床意义。方法 收集2013年7月~2014年3月在柳州市中医院经病理确诊的乳腺癌患者76例和乳腺良性疾病84例,并选同期健康体检妇女50例作为对照组,分别采用免疫比浊法和电化学发光法检测三组的血浆D-二聚体和血清CA153水平,观察其在不同分期及联合检测时的变化。结果 乳腺癌组患者血浆D-二聚体和血清CA153的水平与乳腺良性病组及健康对照组比较差异有统计学意义(t=3.324,4.126; P均<0.05),乳腺良性病组与健康对照组之间血浆D-二聚体和血清CA153水平差异无统计学意义(t=0.586,0.652; P均>0.05); 乳腺癌Ⅲ~Ⅳ期患者血浆D-二聚体和血清CA153的水平与Ⅰ~Ⅱ期患者比较差异有统计学意义(t=1.148,1.412; P均<0.05); D-二聚体及CA153两者联合检测对乳腺癌诊断的敏感度、特异度和准确度分别为93.42%,83.33%和85.63%,联合检测D-二聚体及CA153的准确度与单独检测比较差异有统计学意义(χ2=0.325,0.424; P<0.05)。结论 D-二聚体和CA153联合检测可以提高乳腺癌诊断的准确度,并对乳腺癌的分期有积极意义。

参考文献/References:

[1] 李 婧.血浆D-二聚体检测及其对心房颤动患者血栓诊断的研究进展[J].医学综述,2012,18(5):726-729. Li J.The latest development of detection of plasma D-dimer and itssignificance in diagnosis of thrombi in atrial fibrillation[J].Medical Recapitulate,2012,18(5):726-729.
[2] Ay C,Vormittag R, Dunkler D, et al.D-dimer and prothrombin fragment1+2 predict venous thromboembolism in patients with cancer:results from the Vienna cancer and thrombosis study[J].J Clin Oncol,2009,27(25):4124-4129.
[3] 景 娟,牛 洁,陈 鑫,等.口腔颌面肿瘤患者血浆FBG,D-二聚体和FDP的检测及其意义[J].现代检验医学杂志,2013,28(4):76-78. Jing J,Niu J,Chen X,et al.Significance of detecting plasma FBG,D-dimer and FDP of the patients with oral and maxillofacial tumors[J].Journal of Modern Laboratory Medicine,2013,28(4):76-78.
[4] 王 敏,江铭磊,江 榕,等.血浆D-二聚体在卵巢癌患者围手术期监测中的应用价值[J].中国癌症杂志,2012,22(5):381-384. Wang M,Jiang ML,Jiang R,et al.Application value of monitoring D-dimer for perioperative ovarian cancer patients[J].China Oncology,2012,22(5):381-384.
[5] 张平平,孙军伟,卢久琴,等.非小细胞肺癌患者的基线D-二聚体水平与预后的关系[J].中华肿瘤杂志,2013,35(10):747-750. Zhang PP,Sun JW,Lu JQ,et al.Correlation between baseline plasmaD-dimer levels and prognosis in patients with non-smal cell lung cancer[J].Chinese Journal of Oncology,2013,35(10):747-750.
[6] Batschauer AP,Figueiredo CP,Bueno EC.D-dimer as a possible prognosticmarker of operable hormone receptor-negative breast cancer[J].Annals of Oncology,2010,21(6):1267-1272.
[7] 张 璞.血清CA15-3,CA125,CEA检测在乳腺癌诊断中的临床意义[J].中国实验诊断学,2011,15(10):1705-1707. Zhang P.Breast cancer diagnosis based on quantitative measurementsof serum CA15-3,CA125,and CEA[J].Chinese Journal of Laboratory Diagnosis,2011,15(10):1705-1707.
[8] 冯先华,李金丽,崔天盆.血清MFG-E8与CA15-3,CEA水平对乳腺癌诊断价值的探讨[J].中国实验诊断学,2012,16(4):618-620. Feng XH,Li JL,Cui TP.The serum level of MFG-E8 is valuable biomarker in the diagnosis of breast cancer[J].Chinese Journal of Laboratory Diagnosis,2012,16(4):618-620.
[9] 刘苑欢,魏荣兴,邱群芳.联合检测 CA15-3,CA125,CEA对乳腺癌临床诊断价值探讨[J].实用癌症杂志,2014,29(4):406-408. Liu YH,Wei RX,Qiu QF.Clinical value of combined detection of serum CA15-3,CA125,CEA in the diagnosis of breast cancer[J].The Practical Journal of Cancer,2014,29(4):406-408.
[10] 陈彼得,吴三纲,何振宇,等.术前CEA和CA15-3对乳腺癌的临床应用价值[J].现代肿瘤医学,2012,20(8):1610-1613. Chen BD,Wu SG,He ZY,et al.Clinical value of preoperative CEA and CA15-3 in breast cancer[J].Journal of Modern Oncology,2012,20(8):1610-1613.

相似文献/References:

[1]汪建军,余艳丽,任超杰.胶乳增强免疫比浊法两种定量试剂检测D-二聚体的评价[J].现代检验医学杂志,2015,30(05):141.[doi:10.3969/j.issn.1671-7414.2015.05.044]
 WANG Jian-jun,YU Yan-li,REN Chao-jie.Evaluation of Two Kinds of Quantitative Reagents for Detection of D-Dimer by Latex Enhanced Immune Turbidity[J].Journal of Modern Laboratory Medicine,2015,30(02):141.[doi:10.3969/j.issn.1671-7414.2015.05.044]
[2]施瑞洁,刘文康,李博,等.血浆D-D,FDP及血清hs-CRP检测对多发性腔隙性脑梗死的临床意义[J].现代检验医学杂志,2015,30(06):75.[doi:10.3969/j.issn.1671-7414.2015.06.021]
 SHI Rui-jie,LIU Wen-kang,LI Bo,et al.Clinical Study on Plasma D-D,FDP and Sera hs-CRP Test for Multipleh Lacunar Infarction[J].Journal of Modern Laboratory Medicine,2015,30(02):75.[doi:10.3969/j.issn.1671-7414.2015.06.021]
[3]刘 莎,江咏梅,张 鸽,等.两种试剂D-二聚体检测值 与纤维蛋白降解产物值的相关性研究[J].现代检验医学杂志,2015,30(01):108.[doi:10.3969/j.issn.1671-7414.2015.01.030]
 LIU Sha,JIANG Yong-mei,ZHANG Ge,et al.Study of the Correlation of Testing Results by Two Different D-dimer Reagents with Fibrin Degradation Products Result Values[J].Journal of Modern Laboratory Medicine,2015,30(02):108.[doi:10.3969/j.issn.1671-7414.2015.01.030]
[4]宋文炜.血浆D-二聚体检测对甲状腺癌患者的临床意义[J].现代检验医学杂志,2016,31(06):138.[doi:10.3969/j.issn.1671-7414.2016.06.041]
 SONG Wen-wei.Clinical Significance of Plasma D-dimer Testing in Patients with Thyroid Cancer[J].Journal of Modern Laboratory Medicine,2016,31(02):138.[doi:10.3969/j.issn.1671-7414.2016.06.041]
[5]尹志辉,周志伟a,刘继勇a,等.乳腺癌患者组织多项组化标记物与血清CA153,CA125,CEA,25-OH-D3水平关联性分析模型建立及在预后判断的临床价值[J].现代检验医学杂志,2019,34(03):47.[doi:10.3969/j.issn.1671-7414.2019.03.011]
 YIN Zhi-hui,ZHOU Zhi-weia,LIU Ji-yonga,et al.Establishment of A Correlation Analysis Model betweenMulti-group Markers and Serum CA153,CA125,CEA,25-OH-D3in Breast Cancer Patients and Clinical Value in Prognosis[J].Journal of Modern Laboratory Medicine,2019,34(02):47.[doi:10.3969/j.issn.1671-7414.2019.03.011]
[6]颜宇飞,邓雪梅,刘明利,等.新型冠状病毒肺炎患者血液NLR,DD和 CRP水平联合检测对死亡风险的评估研究[J].现代检验医学杂志,2021,36(01):92.[doi:10.3969/j.issn.1671-7414.2021.01.023]
 YAN Yu-fei,DENG Xue-mei,LIU Ming-li,et al.Novel Coronavirus Pneumonia Patients’ Blood NLR, DD and CRP Levels Combined Detection for the Evaluation of Death Risk[J].Journal of Modern Laboratory Medicine,2021,36(02):92.[doi:10.3969/j.issn.1671-7414.2021.01.023]
[7]付忠晓,黄 俊,王长征,等.COVID-19患者血浆凝血指标及D-二聚体水平检测对临床分型的鉴别价值[J].现代检验医学杂志,2021,36(02):118.[doi:doi:10.3969/j.issn.1671-7414.2021.02.028]
 FU Zhong-xiao,HUANG Jun,WANG Chang-zheng,et al.Preliminary Study on the Differential Value of Coagulation Indexes and D-dimer Level in the Clinical Classification of COVID-19 Patient[J].Journal of Modern Laboratory Medicine,2021,36(02):118.[doi:doi:10.3969/j.issn.1671-7414.2021.02.028]
[8]谭 雍,严 敏,程 珍,等.433例肺血栓栓塞症患者血液 C-反应蛋白、抗凝血酶和纤维蛋白原及血液学变化特点分析[J].现代检验医学杂志,2022,37(01):203.[doi:10.3969/j.issn.1671-7414.2022.01.042]
 TAN Yong,YAN Min,CHENG Zhen,et al.Analysis of Change Feature of CRP ,Antithrombin, Fibrinogen and Hematological Indexs in 433 Patients with PulmonaryThromboembolism[J].Journal of Modern Laboratory Medicine,2022,37(02):203.[doi:10.3969/j.issn.1671-7414.2022.01.042]
[9]段 玮,刘兴晖,李廷俊,等.基于血液炎症相关指标建立儿童复杂性阑尾炎的预测模型及验证[J].现代检验医学杂志,2023,38(02):155.[doi:10.3969/j.issn.1671-7414.2023.02.029 ]
 DUAN Wei,LIU Xing-hui,LI Ting-jun,et al.Establishment of Predictive Models and Verification Based on Related Inflammatory Factors in Blood of Complex Appendicitis in Children[J].Journal of Modern Laboratory Medicine,2023,38(02):155.[doi:10.3969/j.issn.1671-7414.2023.02.029 ]

备注/Memo

备注/Memo:
作者简介:张红雨(1986-),男,本科,检验医师,从事免疫学检验,E-mail:360328467@qq.com。
更新日期/Last Update: 2015-03-20