[1]滑 艳,王海疆.尿液NT-proBNP水平在慢性心力衰竭诊断中的意义[J].现代检验医学杂志,2015,30(02):134-136.[doi:10.3969/j.issn.1671-7414.2015.02.042]
　HUA Yan,WANG Hai-jiang.Significance of Urinary NT-proBNP Levels for Diagnosis of Chronic Heart Failure[J].Journal of Modern Laboratory Medicine,2015,30(02):134-136.[doi:10.3969/j.issn.1671-7414.2015.02.042]
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尿液NT-proBNP水平在慢性心力衰竭诊断中的意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年02期
页码:
134-136
栏目:
检验与临床
出版日期:
2015-03-20

文章信息/Info

Title:
Significance of Urinary NT-proBNP Levels for Diagnosis of Chronic Heart Failure
作者:
滑 艳; 王海疆
惠州市中心人民医院检验中心,广东惠州,516001
Author(s):
HUA Yan; WANG Hai-jiang
Center for ClinicalLaboratory, the Central People's Hospital of Huizhou,Guangdong Huizhou 516001,China
关键词:
尿液;  脑钠肽;  慢性心力衰竭
分类号:
R541.6; R446.122
DOI:
10.3969/j.issn.1671-7414.2015.02.042
文献标志码:
A
摘要:
目的 探讨尿液脑钠肽(NT-proBNP)水平在慢性心力衰竭诊断中是否与血液NT-proBNP水平具有相似的诊断价值。方法 以79例慢性心力衰竭患者﹙NYHAⅠ～Ⅳ级﹚作为研究组,53例健康体检者作为健康对照组,使用德国罗氏公司生产的cobas h 232心脏标志物检测仪分别对两组尿液和血液NT-proBNP水平进行检测,并比较两组尿液NT-proBNP与血液NT-proBNP水平之间的差异。结果慢性心力衰竭患者组的尿液NT-proBNP和血液NT-proBNP水平均高于健康对照组,差异具有统计学意义(P<0.01)。随心功能NYHA分级的增高,尿液NT-proBNP水平逐渐升高。尿液NT-proBNP水平与血液NT-proBNP水平呈正相关。结论 尿液NT-proBNP水平在慢性心力衰竭诊断中具有重要的临床意义,与血液NT-proBNP水平具有相似的诊断价值。
Abstract:
Objective To investigate the value of the levels of urinary NT-proBNP whether is similar with the levels of blood NT-proBNPfor the diagnosis of chronic heart failure.Methods 79 patients with chronic heart failure(NYHA Ⅰ～Ⅳ)as a research group,and 53 healthy people as a control group,the levels of urinary and blood NT-proBNP on two groups were measured respectively by Roche cobas h 232 cardiac markers detector and compared the difference of the levels of urinary NT-proBNP and blood NT-proBNP between the two groups.Results The levels of urinary and blood NT-proBNP in patients with chronic heart failure were much higherthan those in healthy subjects,respectively(P<0.01).The concentration of urinary NT-proBNP increased gradually with more severe symptoms.The level ofurinary NT-proBNP was positively correlated with the levels of blood NT-proBNP.Conclusion The levels of urinary NT-proBNP is a new candidate marker for the diagnosis of chronic heart failures and it provides a similar accuracy with the levels of blood.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:滑 艳(1965-),女,理学博士,主任技师,从事临床医学检验,Tel:13542793939,E-mail:huayan 16@163.com。
更新日期/Last Update: 2015-03-20