[1]李友建,顾桂兰,王志勇,等.同型半胱氨酸、糖化血红蛋白和血脂与后循环缺血的相关性研究[J].现代检验医学杂志,2015,30(02):132-133,136.[doi:10.3969/j.issn.1671-7414.2015.02.041]
　LI You-jian,GU Gui-lan,WANG Zhi-yong,et al.Relationship between Homocysteine,Glycosylated Hemoglobin, Lipids and Posterior Circulation Ischemia[J].Journal of Modern Laboratory Medicine,2015,30(02):132-133,136.[doi:10.3969/j.issn.1671-7414.2015.02.041]
点击复制

同型半胱氨酸、糖化血红蛋白和血脂与后循环缺血的相关性研究()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年02期
页码:
132-133,136
栏目:
检验与临床
出版日期:
2015-03-20

文章信息/Info

Title:
Relationship between Homocysteine,Glycosylated Hemoglobin, Lipids and Posterior Circulation Ischemia
作者:
李友建; 顾桂兰; 王志勇; 汪 峰; 金灿灿
泰兴市人民医院检验科,江苏泰兴 225400
Author(s):
LI You-jian; GU Gui-lan; WANG Zhi-yong; WANG Feng; JIN Can-can
Department of Clinical Laboratory,Taixing People's Hospital,Jiangsu Taixing 225400,China
关键词:
同型半胱氨酸;  糖化血红蛋白;  血脂;  后循环缺血
分类号:
R743.31; R446.112
DOI:
10.3969/j.issn.1671-7414.2015.02.041
文献标志码:
A
摘要:
目的 比较同型半胱氨酸(homocysteine,HCY)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、脂类等与后循环缺血的关系,探讨其水平在后循环缺血疾病的临床意义。方法 对140例临床诊断为后循环缺血患者和正常健康对照组,清晨空腹采集静脉血样,测定HCY,HbA1c,总胆固醇(TC),三酰甘油(TG),高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)水平,比较受试组和对照组的差异。结果 经两独立样本t检验,后循环缺血患者HCY和HbA1c均明显高于对照组(P<0.001); HDL-C则明显低于对照组(P=0.001),差异有统计学意义,其余脂类指标与对照组比较差异均无统计学意义。Spearman秩相关分析显示受试者年龄与HCY水平(P<0.001)呈显著正相关,和TG水平(P=0.013)呈显著负相关; HCY与TG水平(P=0.028)呈显著负相关; HbA1c与TG水平(P=0.001)和LDL-C水平(P=0.027)呈显著正相关。结论 HCY和HbA1c水平升高与后循环缺血密切相关,提示了应高度重视HCY和HbA1c对于有效防治后循环缺血疾病以及改善其预后有重要的意义。
Abstract:
Objective To explore the relationship betweenhomocysteine(HCY),glycosylated hemoglobin(HbA1c),lipids and posterior circulation ischemia and the clinical significance of their levels in the posterior circulation ischemic(PCI)diseases.Methods Difference between PCI were diagnosed in 140 examinees and a healthy control group,with fastingserum,HCY,HbA1c,total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)were detected.Results HCY and HbA1c were significantly higher,HDL-C was significantly lower in the patients with PCI,two independent sample t-test showed a significant difference between the test group and control group(P<0.001 and P=0.001),the remaining lipid indicators was not statistically significant.Spearman rank correlation analysis showed that HCYlevels had significant positive correlation(P<0.001)and TG levels had significant negative correlation(P=0.013)with the subjects age,HCY levelshad significant negative correlation with TG levels(P=0.028),HbA1c levelshad significant positive correlation with TG levels and LDL-C levels(P=0.001 and P=0.027).Conclusion High levels of HCY andHbA1c were closely associated with PCI,which HCY and HbA1c should be attached great importance to the effective prevention and treatment and improve of PCI.

参考文献/References:

[1] Sun Q,Jia X,Gao J,et al.Association of serum homocysteine levels with the severity and calcification of coronary atherosclerotic plaques detected by coronary CT angiography[J].Int Angiol,2014,33(4):316-323.
[2] Akyürek(¨overo),Akbal E,Günes F.Increase in the risk of ST elevation myocardial infarction is associated with homocysteine level[J].Arch Med Res,2014,45(6):501-506.
[3] Kwon HM,Lee YS,Bae HJ,et al.Homocysteine as a predictor of early neurological deterioration in acute ischemic stroke[J].Stroke,2014,45(3):871-873.
[4] 李友建,顾桂兰,王志勇,等.糖化血红蛋白在脑血管疾病中临床应用的探讨[J].现代检验医学杂志,2014,29(2):146-148. Li YJ,Gu GL,Wang ZY,et al.Clinical application of glycosylated hemoglobin in the cerebrovascular disease[J].J Mod Lab Med,2014,29(2):146-148.
[5] Selvin E,Marinopoulos S,Berkenblit G,et al.Meta-analysis:glycoylated hemoglobin and cardiovascular disease in diabetes mellitus[J].Ann Intern Med,2004,141(6):421-431.

相似文献/References:

[1]张曙晴a,李洪彬b,张骆军a,等.2型糖尿病患者糖化血红蛋白水平与胰岛素分泌及胰岛素抵抗的关系[J].现代检验医学杂志,2016,31(02):108.[doi:10.3969/j.issn.1671-7414.2016.02.032]
　ZHANG Shu-qinga,LI Hong-binb,ZHANG Luo-juna,et al.Correlation between Insulin Secretion,Insulin Resistance and Glycosylated Hemoglobin Levels in Patients with Type 2 Diabetic[J].Journal of Modern Laboratory Medicine,2016,31(02):108.[doi:10.3969/j.issn.1671-7414.2016.02.032]
[2]张诗诗,王 薇,赵海建,等.Westgard西格玛规则在糖化血红蛋白检验项目室内质量控制中的选择应用[J].现代检验医学杂志,2016,31(02):157.[doi:10.3969/j.issn.1671-7414.2016.02.046]
　ZHANG Shi-shi,WANG Wei,ZHAO Hai-jian,et al.Application of Westgard Sigma Rules in Selecting Internal Quality Control Rules for Hemoglobin A1C Tests[J].Journal of Modern Laboratory Medicine,2016,31(02):157.[doi:10.3969/j.issn.1671-7414.2016.02.046]
[3]张 路,王 薇,何法霖,等.国内临床实验室同型半胱氨酸室内质量控制变异系数调查与分析[J].现代检验医学杂志,2015,30(04):132.[doi:10.3969/j.issn.1671-7414.2015.04.040]
　ZHANG Lu,WANG Wei,HE Fa-lin,et al.Investigation and Analysis of the Coefficient of Variation of Internal Quality Control of Homocysteine[J].Journal of Modern Laboratory Medicine,2015,30(02):132.[doi:10.3969/j.issn.1671-7414.2015.04.040]
[4]赵佳a,姚创利a,左林,等.冠心病患者血清同型半胱氨酸对血脂和锰超氧化物歧化酶的影响[J].现代检验医学杂志,2015,30(05):44.[doi:10.3969/j.issn.1671-7414.2015.05.013]
　ZHAO Jiaa,YAO Chuang-lia,ZUO Lin,et al.Effects of Homocysteine on Blood Lipid and Manganese Superoxide Dismutase in Patients with Coronary Heart Disease[J].Journal of Modern Laboratory Medicine,2015,30(02):44.[doi:10.3969/j.issn.1671-7414.2015.05.013]
[5]张瑞.脑梗死患者血清同型半胱氨酸、血浆叶酸和维生素B12水平的相关性研究[J].现代检验医学杂志,2015,30(05):118.[doi:10.3969/j.issn.1671-7414.2015.05.036]
　ZHANG Rui.Correlation Study on Homocysteine，Plasma Folate and Vitamin B12 Levels in Serum of Cerebral Infarction Patients[J].Journal of Modern Laboratory Medicine,2015,30(02):118.[doi:10.3969/j.issn.1671-7414.2015.05.036]
[6]高 科,陶 娟,范 宁,等.联合检测三种生化指标对糖尿病肾病早期诊断的临床价值分析[J].现代检验医学杂志,2016,31(04):117.[doi:10.3969/j.issn.1671-7414.2016.04.033]
　GAO Ke,TAO Juan,FAN Ning,et al.Analysis of Combined Detection of Three Kinds of Biochemical Indexes of Clinical Value for Early Diagnosis of Diabetic Nephropathy[J].Journal of Modern Laboratory Medicine,2016,31(02):117.[doi:10.3969/j.issn.1671-7414.2016.04.033]
[7]国钰梅,马 龙,潘国涛,等.急性缺血性脑卒中患者同型半胱氨酸水平与出院结局的关联研究[J].现代检验医学杂志,2016,31(05):23.[doi:10.3969/j.issn.1671-7414.2016.05.006]
　GUO Yu-mei,MA Long,PAN Guo-tao,et al.Relationship between Homocysteine Levels in Patients with Acute Ischemic Stroke and Discharged Outcome[J].Journal of Modern Laboratory Medicine,2016,31(02):23.[doi:10.3969/j.issn.1671-7414.2016.05.006]
[8]周萍,肖尧,袁瑞丽,等.血清Hcy和hs-CRP水平检测在AMI早期临床诊断中的临床应用[J].现代检验医学杂志,2016,31(06):79.[doi:10.3969/j.issn.1671-7414.2016.06.022]
　ZHOU Ping,XIAO Yao,YUAN Rui-li,et al.Application Value of Serum Hcy and hs-CRP Levels in Early Diagnosis of AMI[J].Journal of Modern Laboratory Medicine,2016,31(02):79.[doi:10.3969/j.issn.1671-7414.2016.06.022]
[9]范艳平a,易甲其a,吴 敏b.缺血性脑卒中患者血清Hcy和EPO水平的变化及其与颈动脉粥样硬化关系[J].现代检验医学杂志,2017,32(01):80.[doi:10.3969/j.issn.1671-7414.2017.01.022]
　FAN Yan-pinga,YI Jia-qia,WU Minb.Changes of Serum Hcy and EPO Levels in Patients with Ischemic Stroke and Their Relationship with Carotid Artery Atherosclerosis[J].Journal of Modern Laboratory Medicine,2017,32(02):80.[doi:10.3969/j.issn.1671-7414.2017.01.022]
[10]左 林,赵 佳,姜小建,等.缺血性脑血管病患者血清同型半胱氨酸、叶酸和维生素B12水平与头颈部血管狭窄的相关性研究[J].现代检验医学杂志,2017,32(02):23.[doi:10.3969/j.issn.1671-7414.2017.02.006]
　ZUO Lin,ZHAO Jia,JIANG Xiao-jian,et al.Correlation Study between Serum Homocysteine, Folate,Vitamin B12 Levels and Head and Neck Vascular Stenosis in Patients with Ischemic CerebroVascular Disease[J].Journal of Modern Laboratory Medicine,2017,32(02):23.[doi:10.3969/j.issn.1671-7414.2017.02.006]

备注/Memo

备注/Memo:
作者简介:李友建(1975-),男,硕士,副主任检验技师。
更新日期/Last Update: 2015-03-20