[1]武冬娜,张文杰,唐招平,等.血清Cys C和24h尿微量清蛋白定量联合检测对妊娠期糖尿病肾病的早期诊断价值[J].现代检验医学杂志,2015,30(02):139-141.[doi:10.3969/j.issn.1671-7414.2015.02.044]
　WU Dong-na,ZHANG Wen-jie,TANG Zhao-ping,et al.Diagnostic Value of Combined Measuring of Serum Cystatin C and 24 h Urine Microalbumin in Early Gestational Diabetes Kidney Disease[J].Journal of Modern Laboratory Medicine,2015,30(02):139-141.[doi:10.3969/j.issn.1671-7414.2015.02.044]
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血清Cys C和24h尿微量清蛋白定量联合检测对妊娠期糖尿病肾病的早期诊断价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年02期
页码:
139-141
栏目:
检验与临床
出版日期:
2015-03-20

文章信息/Info

Title:
Diagnostic Value of Combined Measuring of Serum Cystatin C and 24 h Urine Microalbumin in Early Gestational Diabetes Kidney Disease
作者:
武冬娜; 张文杰; 唐招平; 周 勇; 王亚峰; 韩俊峰; 贾 卉
陕西省妇幼保健院,西安 710032
Author(s):
WU Dong-na; ZHANG Wen-jie; TANG Zhao-ping; ZHOU Yong; WANG Ya-feng; HAN Jun-feng;  JIA Hui
Shaanxi Provincial Maternal and Child Health Care Hospital,Xi'an 710032,China
关键词:
胱抑素C;  尿微量清蛋白;  联合检测;  糖尿病肾病
分类号:
R587.2; R446.112
DOI:
10.3969/j.issn.1671-7414.2015.02.044
文献标志码:
A
摘要:
目的 探讨血清胱抑素C(Cys C)和24 h尿微量清蛋白定量联合检测在妊娠期糖尿病肾病(GDN)早期诊断中的应用价值。方法 选取110例孕37～40周妊娠期糖尿病患者为研究对象,根据肾小球滤过率(GFR)将其分为GFR中度下降30例为A组(30 ml/min/1.73m2≤GFR<60 ml/min/1.73m2),GFR轻度下降42例为B组(60 ml/min/1.73m2≤GFR<89 ml/min/1.73m2),GFR正常38例为C组(GFR≥90 ml/min/1.73 m2)。选取同期健康相同孕周孕妇40例作为对照D组。统计4组研究对象的血清Cys C和尿微量清蛋白、血尿素、血肌酐水平,进行统计分析。结果Cys C和尿微量清蛋白各组之间比较,差异均有统计学意义(F=31.21,34.70,P<均0.01)。血尿素和肌酐A组和其他各组比较,差异均有统计学意义(F=5.85,4.58,P均<0.01),血尿素和肌酐在B组、C组和D组之间比较,差异均无统计学意义(P>0.05)。A组和B组的血清Cys C与尿微量清蛋白间存在正相关关系(r=0.756,0.725,t=5.209,4.835,P均<0.01)。B组中Cys C的诊断敏感度为95.2%,24 h尿微量清蛋白的诊断敏感度为90.5%,两者联合检测的敏感度为100%(χ2=8.24,7.08,P均<0.05)。结论 血清Cys C和尿微量清蛋白作为妊娠糖尿病早期肾损害的敏感指标,联合检测对妊娠糖尿病肾病早期诊断及病情监测具有重要意义。
Abstract:
Objective To investigate the diagnostic value of serum Cystatin C and 24 h urine microalbumin quantitative examination in the early gestational diabetes kidney.Methods Chose 110 cases of patients from 37 to 40 weeks during pregnancy with gestational diabetes.According to the GFR,patients were divided into GFR moderate decline group A(30 ml/min/1.73m2≤GFR<60ml/min/1.73m2,n=30),GFR mild decline group B(60 ml/min/1.73m2≤GFR<89 ml/min/1.73m2,n=42)and GFR normal group C(GFR≥90 ml/min/1.73 m2,n=38).Choose the same gestational weeks 40 healthy pregnants cases as control group D.Statistics of four groups of serum Cys C,24 h urine microalbumin quantitative,serum urea and creatinine,then analize.Results The levels of serum cystatin C andurine microalbumin compared between each group respectively,the differences were statistically significant(F=31.209,34.698,P<0.01,respectively).Thelevels of blood urea and creatinine in group A when compared with the other groups,found that the difference was statistically significant(F=5.845,4.575,P<0.01,respectively).When comparing the levels of blood urea and creatinine among the groups B,C and D,there was no statistical difference of significance(P>0.05).There was positive correlation between levels serum Cys C andurine microalbumin in group A and B(r=0.756,0.725,t=5.209,4.835,P<0.01,respectively).The sensitivity of Cys C and urine microalbumin were 95.2% and 90.5%,sensitivity of the combination of Cys C and urine microalbuminwas 100%(χ2=8.24,7.08,P<0.05,respectively).ConclusionAs sensitive indicators of gestational diabetes in the early renaldamage stage,joint detection of Cys C and urine microalbumin is of great significance for diagnosis and monitoring of diabetes in the early renal damage stage.

参考文献/References:

[1] 谢 幸,苟文丽.妇产科学[M].8版.北京:人民卫生出版社,2013:75-79. Xie X,Gou WL.Obstetrics and Gynecology[M].8th Ed.Beijing:People's Medical Publishing House,2013:75-79.
[2] 曹忠帅,闫 峰,马淑红.血清胱抑素C(Cys C)对轻中度肾损伤的诊断价值[J].中国实验诊断学,2013,17(8):1443-1445. Cao ZS,Yan F,Ma SH.The diagnostic value of serum Cystatin C(Cys C)in the mild and moderate renal in Jury[J].Chinese Journal of Laboratory Diagnosis,2013,17(8):1443-1445.
[3] 李红丽.尿微量白蛋白、血清糖化血红蛋白和血清胱抑素C联合检测在糖尿病早期肾损伤诊断中的价值[J].陕西医学杂志,2013,42(3):361-362. Li HL.Value of joint examination of the urine trace albumin,serumglycosylated hemoglobin and serum Cystatin C in the diagnosis of diabetes earlyrenal damage[J].Shaaxi Medical Journal,2013,42(3):361-362.
[4] 陈 鑫,王开宇,兰小鹏.探讨胱抑素C在慢性肾病中的诊断价值[J].现代检验医学杂志.2011,26(6):70-72. Chen X,Wang KY,Lan XP.Analyzing the value of CysC in diagnosing CKD[J].Journal of Modern Laboratory Medicine,2011,26(6):70-72.
[5] 刘 健,欧阳清,石青峰.血清胱抑素C联合尿微量白蛋白在妊娠期糖尿病早期肾损害诊断中的价值[J]. 中国实验诊断学,2012,16(6):1131-1133. Liu J,Ou YQ,Shi QF.Diagnostic value of the combinative measuringof serum cystatin C and microalbumin in gestationgal diabetes mellitus patientswith early renal injury[J].Chinese Journal Laboratory Diagnosis,2012,16(6):1131-1133.
[6] 张成诗,吴 兵,魏光明.血清Cys C,Hcy和U-mALB联合检测在早期糖尿病肾病诊断中的临床应用研究[J].中国实验诊断学,2014,18(5):733-735. Zhang CS,Wu B,Wei GM.The diagnostic value of Cys C,Hcy and U-mAlb cinjoined detection for early diabetic mephropathy[J].Chinese Journal of Laboratory Diagnosis,2014,18(5):733-735.

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备注/Memo

备注/Memo:
作者简介:武冬娜(1976-),女,硕士,主管检验师,专业:生化检验,E-mail:dongna2860@sina.com。
更新日期/Last Update: 2015-03-20