[1]翟华丽,刘艳丽,丁丽丽,等.2012～2014年医院血培养主要病原菌分布及耐药性分析[J].现代检验医学杂志,2015,30(03):104-106.[doi:10.3969/j.issn.1671-7414.2015.03.030]
　ZHAI Hua-li,LIU Yan-li,DING Li-li,et al.Distribution and Drug Resistance of Main Pathogens Isolated from Blood Culture from 2012 to 2014[J].Journal of Modern Laboratory Medicine,2015,30(03):104-106.[doi:10.3969/j.issn.1671-7414.2015.03.030]
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2012～2014年医院血培养主要病原菌分布及耐药性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年03期
页码:
104-106
栏目:
论著
出版日期:
2015-06-10

文章信息/Info

Title:
Distribution and Drug Resistance of Main Pathogens Isolated from Blood Culture from 2012 to 2014
文章编号:
1671-7414(2015)03-104-04
作者:
翟华丽1; 刘艳丽1; 丁丽丽1; 程庆妮1; 邹爱民1; 沈建军2
1.长安医院检验科,西安 710016;
2.唐都医院检验科,西安 710038
Author(s):
ZHAI Hua-li1; LIU Yan-li1; DING Li-li1; CHENGQing-ni1; ZOU Ai-min1; SHEN Jian-jun2
1.Department of Clinical Laboratory,Chang'an Hospital,Xi'an710016,China;
2.Department of Clinical Laboratory,Tangdu Hospital,Xi'an 710038,China
关键词:
血流感染;  病原菌;  耐药性;  合理用药
分类号:
R446.5
DOI:
10.3969/j.issn.1671-7414.2015.03.030
文献标志码:
A
摘要:
目的 了解血培养标本病原菌分布及其耐药性,为临床合理使用抗生素提供实验室依据。方法 回顾性分析长安医院2012年～2014年血培养标本中主要病原菌分布、变迁及耐药情况。结果 2012～2014年送检血培养4 792例,检出病原菌512株,其中革兰氏阴性菌62.50%(320/512),以大肠埃希菌25.20%(129/512)、肺炎克雷伯菌14.26%(73/512)、铜绿假单胞菌8.20%(42/512)为主; 革兰氏阳性菌29.30%(150/512),以金黄色葡萄球菌11.52%(59/512)、凝固酶阴性葡萄球菌10.16%(52/512)为主; 真菌7.62%(39/512)。药敏结果显示:大肠埃希菌、肺炎克雷伯菌对碳青霉烯类药物敏感性较高,对其他多种抗菌药均有不同程度耐药; 革兰氏阳性球菌对青霉素、红霉素、克林霉素普遍耐药,未发现耐万古霉素、利奈唑胺的菌株。结论 血培养病原菌种类分布广,耐药形势严峻,及时准确检测病原菌分布及耐药情况,为临床合理使用抗菌药物提供依据。
Abstract:
Objective To understand the distribution and drug resistance of pathogens isolated from blood culture samples Chang'an Hospital from 2012 to 2014 to provide basis for rational use of antibacterial drugs.Methods The clinical date of distribution,changes and drugresistance of main pathogens in blood culture samples during 2012 and 2014 in chang anhospital were retrospectively analyzed.Results 512 pathogenic bacterial strains were isolated from 4 792 blood culture samples in2012～2014.Among them,gram-negative bacteria accounted for 62.50%(320/512),Escherichia coli,Klebsiella pneumoniae and Pseudomonas aeruginosa accounted for 25.20%(129/512),14.26%(73/512)and 8.20%(42/512)respectively; Gram-positive bacteria accounted for 29.30%(150/512),Staphylococcus aureus and Coagulase-negative Staphylococcus accounted for 11.52%(59/512)and 10.16%(52/512)respectively.The rate of fungi was 7.62%(39/512).Susceptibility results showed that Escherichia coli and Klebsiella pneumoniae had highly sensitive to carbapenems,but had a varying degrees of resistance to other antibacterial drugs.The rate of drug resistant of Gram-positive cocci toPenicillin,Erythromycin and Clindamycin had been a high level,but no strains being resistant to van comycin and linezolid had been detected.Conclusion The pathogens causing bloodstream infection widely distribute,and have highly drug-resistant.It is necessary to understand the distribution of pathogens isolated from blood culture as well as the changes of drugresistance in a timely manner so as to guide the reasonable clinical medication.

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备注/Memo

备注/Memo:
基金项目:西安市科技攻关项目(HM1124)。
作者简介:翟华丽(1982-),女,本科,主管技师,临床微生物学,E-mail:aiminzou2001@sina.com。
通讯作者:沈建军,副主任技师,主要从事临床检验,E-mail:13572907376@163.com。
更新日期/Last Update: 2015-06-10