[1]孙继红,张 艳,剌 梅,等.中老年人群甲状腺激素与血清NT-proBNP的相关性研究分析[J].现代检验医学杂志,2015,30(04):147-149.[doi:10.3969/j.issn.1671-7414.2015.04.045]
　SUN Ji-hong,ZHANG Yan,LA Mei,et al.Correlation Analysis of Serum Thyroid Hormone NT-proBNP in OlderAdults[J].Journal of Modern Laboratory Medicine,2015,30(04):147-149.[doi:10.3969/j.issn.1671-7414.2015.04.045]
点击复制

中老年人群甲状腺激素与血清NT-proBNP的相关性研究分析()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年04期
页码:
147-149
栏目:
检验与临床
出版日期:
2015-08-10

文章信息/Info

Title:
Correlation Analysis of Serum Thyroid Hormone NT-proBNP in OlderAdults
文章编号:
1671-7414(2015)04-147-04
作者:
孙继红; 张 艳; 剌 梅; 肖曼丽; 沈建华
延安大学咸阳医院,陕西咸阳 712000
Author(s):
SUN Ji-hong; ZHANG Yan; LA Mei; XIAO Man-li; SHEN Jian-hua
Xianyang Hospital of Yanan University,Shaanxi Xianyang 712000,China
关键词:
中老年人群;  N端-脑钠肽前体;  NT-proBNP;  甲亢心;  甲状腺激素
分类号:
R392.11
DOI:
10.3969/j.issn.1671-7414.2015.04.045
文献标志码:
A
摘要:
目的 探讨中老年人群N端-脑钠肽前体(N-terminal pro-B-type natriuretic peptide,NT-proBNP)在甲状腺功能紊乱疾病中的变化及其相关性。方法 采用电化学发光分析仪检测38例甲状腺功能亢进性心脏病(甲亢心组)、68例甲状腺功能亢进症(甲亢组)、31例甲状腺功能减退症(甲减组)患者及43例健康对照者血清NT-proBNP水平; 对比分析各组别老年人群与中年人群血清NT-proBNP水平的差异,并分析其相关性。结果 甲亢心组、甲亢组、甲减组与正常对照组血清NT-proBNP结果分别是827.61±626.13,107.18±54.46,162.94±134.14和68.76±39.21 pg/ml。甲亢心组、甲亢组、甲减组与正常对照组比较,血清NT-proBNP水平差异均有统计学意义(t=7.458,4.312,3.794; P= 0.000,0.000,0.001); 甲亢心组、甲减组与甲亢组血清NT-proBNP水平比较差异有统计学意义(t=7.078,2.232; P=0.000,0.032)。甲亢心组、甲减组、正常对照组老年人群血清NT-proBNP水平高于中年人群,差异有统计学意义(t=-3.216,-2.510,-2.653; P=0.007,0.016,0.014); 甲亢组老年人群血清NT-proBNP水平高于中年人群,但差异无统计学意义(t=-0.140,P=0.890)。多元回归分析示甲亢组血清NT-proBNP水平与FT4(r=0.224,P=0.033)存在正相关; 甲减组血清NT-proBNP水平与T3(r=-0.363,P=0.022)存在负相关。结论 中老年人群甲状腺功能紊乱对血清NT-proBNP的水平有显著性影响,血清NT-proBNP水平对不同甲状腺功能状态人群的辅助诊断和疗效观察具有一定临床价值。
Abstract:
Objective To discuss the aged people N-terminal pro-B-type natriuretic peptide(NT-proBNP)changes in thyroid function disorder and its correlation.Methods With electrochemicalluminescence analyzer,detected serum NT-proBNP level 38 patients with hyperthyroid heart disease,68 patients with hyperthyroidism,31 patients with hypothyroidism,and 43 cases of healthy controls.Compared each groupserum NT-proBNP level of older population with middle-aged people,and analysied the correlation.Results The serum NT-proBNP level of Hyperthyroidismheart group,hyperthyroidism,hypothyroidism group and normal control group were827.61±626.13,107.18±54.46,162.94±134.14,68.76±39.21 pg/ml,respectively.The serum level of HT-pro BNP.Hyperthyroidism group,hyperthyroidism,hypothyroidism group compared with normal control group,there were statistically significan(t=7.458,4.312,3.794,P=0.000,0.000,0.001).Hyperthyroidism heart,hypothyroidism with hyperthyroidism group serumlevel of NT-proBNP comparison there was statistical significance(t=7.078,2.232; P=0.000,0.032).Hyperthyroidism heartgroup,hypothyroidism group andnormal control group older population was higher than the level of serum NT-proBNP middle-aged,difference was statistically significant(t=-3.216,-2.510,-2.653; P=0.007,0.016,0.014).Hyperthyroidism group of elderly serum NT-proBNP level higher than that of middle-aged people,but there was no statistically significant difference(t=-0.140,P=0.890).Multiple regression analysis in hyperthyroidism group serum levels of NT-proBNP and FT4 had positive correlation(r=0.224,P=0.033)and hypothyroidismgroup serum levelsof NT-proBNP and T3 had negative correlation(r=-0.363,P=0.022).Conclusion Thyroid dysfunction in elderly people for the level of serum NT-proBNP had significant influence.Auxiliary disgnosis and curative effect observationof the serum level of NT-proBNP in people with different thyroid functional status has certain clinical value.

参考文献/References:

[1] 欧阳春,赵秋玲,张里克.血浆N端-脑钠肽前体水平与甲状腺激素的相关性分析[J].内科急危重症杂志,2009,15(5):257-259.
Ou YZ,Zhao QL,Zhang LK.Analysis of correlation between NT-ProBNPlevel and thyroid hormones[J].Journal of Internal Intensive Medicine,2009,15(5):257-259.
[2] 袁 超,李卫鹏,刘恒超,等.甲状腺功能与血浆BNP的临床相关性研究[J].放射免疫学杂志,2009,22(5):517-519.
Yuan C,Li WP,Liu HC,et al.Clinical study on plasma B-type natriuretic peptide levels in different thyroid function status[J].J Radioimmunology,2009,22(5):517-519.
[3] 赵连爽,潘丽杰,赵玉霞,等.B型钠尿肽对甲状腺功能亢进性心脏病的诊断和心功能状态评估的价值及意义[J].中华临床医师杂志(电子版),2012,6(14):4048-4050.
Zhao LS,Pan LJ,Zhao YX,et al.B-type natriuretic peptide in thediagnosis of thyroid function hyperfunction sex heart disease and heart functionstate evaluation of value and significance[J].Chinese Journal of Clinicians(Electrontc Edition),2012,6(14):4048-4050.
[4] 叶任高,陆再英.内科学[M].6版.北京:人民卫生出版社,2005:728.
Ye RG,Lu ZY.Internal medicine[M].6th Edition.Beijing:People's Medical Publishing House,2005:728.
[5] 赵 雅,兰雅娴,王 禹,等.甲亢患者血清NT-proBNP水平的测定及与FT3,FT4的相关性研究[J].现代检验医学杂志,2010,25(2):71-73.
Zhao Y,Lan YX,Wang Y,et al.Determination of serum NT-proBNP level in hyperthyroidism patients and its correlation with FT3 and FT4[J].Journal of Modern Laboratory Medicine,2010,25(2):71-73.
[6] 陈 昌,方林彬.不同甲状腺功能状态患者血浆B型钠尿肽的检测及其临床意义[J].广东医学院学报,2007,25(4):393-394.
Chen C,Fang LB.Plasma level of B-type natriuretic peptide in patients with different thyroid function states[J].Journal of Guangdong Medical College,2007,25(4):393-394.
[7] 鲁 惠.血清NT-proBNP水平与甲状腺功能的相关性研究[J].国际检验医学杂志,2011,32(12):1389-1390.
Lu H.The correlation between serum level of NT-proBNP and thyroidfunction study[J].International Journal of Laboratory Medicine,2011,32(12):1389-1390.
[8] Hammerer-Lercher A,Neubauer E,Pachinger O,et al.Head-to-head comparison of N-terminal pro-brain natriuretic peptide,brain natriuretic peptideand N-terminal pro-atrial natriuretic peptide in diagnosing left ventricular dysfunction[J].Clinica Chmica Acta,2001,310(2):193-197.

备注/Memo

备注/Memo:
作者简介:孙继红(1970-),女,大学本科,副主任检验师,主要从事免疫学研究,Tel:13891050655,E-mail:245029068@qq.com。
更新日期/Last Update: 2015-08-10