[1]归巧娣,任健康,宫艳艳,等.陕西省细菌耐药监测网2015年血流感染病原菌分析[J].现代检验医学杂志,2016,31(05):59-61，65.[doi:10.3969/j.issn.1671-7414.2016.05.015]
　GUI Qiao-di,REN Jian-kang,GONG Yan-yan,et al.Drug Resistance of Pathogens in Blood Culture Specimens in Shaanxi Antimicrobial Resistant Investigation Net in 2015[J].Journal of Modern Laboratory Medicine,2016,31(05):59-61，65.[doi:10.3969/j.issn.1671-7414.2016.05.015]
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陕西省细菌耐药监测网2015年血流感染病原菌分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年05期
页码:
59-61，65
栏目:
论著
出版日期:
2016-10-21

文章信息/Info

Title:
Drug Resistance of Pathogens in Blood Culture Specimens in Shaanxi Antimicrobial Resistant Investigation Net in 2015
文章编号:
1671-7414(2016)05-059-04
作者:
归巧娣1; 任健康1; 宫艳艳1; 苍金荣1; 范 芸1; 陈 苗1; 乔 军2
1.陕西省人民医院检验科,西安 710068;
2.西安市长安区医院,西安710100
Author(s):
GUI Qiao-di1; REN Jian-kang1; GONG Yan-yan1; CANG Jin-rong1; FAN Yun1; CHEN Miao1;  Qiao Jun2
1.Department of Clinical Laboratory,Shaanxi Provincial People's Hospital, Xi'an 710068,China;
2.Changan District Hospital Xi'an,Xi'an 710100,China
关键词:
细菌耐药监测;  血流感染
分类号:
R446.5
DOI:
10.3969/j.issn.1671-7414.2016.05.015
文献标志码:
A
摘要:
目的 统计分析陕西省细菌耐药监测网成员单位2015年血流感染病原菌分布及耐药情况,为陕西省抗菌药物合理应用提供依据。方法 各成员单位按照监测方案要求,进行目标细菌鉴定、药敏试验,依据CLSI 2014年标准,用WHONET5.6软件进行数据分析。结果 共收集细菌6 871株,其中革兰阴性菌3 199株,占46.56%,革兰阳性菌3 672株,占53.44%。革兰阳性菌中,分离前五位分别为表皮葡萄球菌1 136株(30.94%)、人葡萄球菌655株(17.84%)、溶血葡萄球菌431株(11.74%)、金黄色葡萄球菌356株(9.69%)和屎肠球菌231株(6.29%); 革兰阴性菌中分离前五位的分别是大肠埃希菌1 397株(43.67%)、嗜麦芽窄食单胞菌468株(14.63%)、肺炎克雷伯菌431株(13.47%)、铜绿假单胞菌132株(4.13%)和鲍曼不动杆菌116株(3.63%)。耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林表皮葡萄球菌(MRCNS)的检出率分别为31.2%和76.1%,未发现万古霉素耐药的金黄色葡萄球菌。万古霉素耐药屎肠球菌发生率0.9%。革兰阴性杆菌中,肠杆菌科细菌对碳青霉烯类抗生素耐药率<4.0%。鲍曼不动杆菌对包括亚胺培南在内的大多数监测药物耐药率超过50.0%,而铜绿假单胞菌对大多数药物保持了较高的抗菌活性。结论 陕西省血流感染细菌耐药情况较为严重,应充分利用该地区细菌耐药监测结果进行监督管理,促进抗菌药物合理应用。
Abstract:
Objective To explore the bacterial drug resistance in blood culture in 2015 from the members of Antimicrobial Resistant Investigation Net of Shaanxi province,and to guide the clinicians touse antimicrobialdrugs rationally.Methods All the objective bacterial isolates were collected and identifiedsusceptibility date by software WHONET 5.6.Results 6 871 bacterial isolates and their antibacterialsusceptibilitydata were collected which included 3 199(46.56%)Gram-negativebacterial isolates and 3 672(53.44%)Gram-positivebacterial isolates.The topfive populationsof Gram-positive bacterial isolates were Staphylococcus epidermidis(30.94%),Staphylococcus hominis(17.84%),Staphylococcus haemolyticus(11.74%),Staphylococcus aureus(9.69%)and Enterococcus feacium(6.29%).The top five populationsof Gram-negative bacterial isolates were E.coli(43.67%),Stenotrophomonas maltophilia(14.63%),K.pneumoniae(13.47%),P.aeruginosa(4.13%)and Acinetobacter baumannii(3.63%).Theisolating rates of methicillin-resistant Staphylococcus aureus(MRSA)and methicillin-resistant coagulase negative Staphylococcus(MRCNS)were 31.2% and 76.1%,respectively.No vancomycin resistant Staphylococcusisolates were found.There were 0.9% E.faecium vancomycin-resistant isolates.The isolates of Enterobacteriaceae were still highly susceptible to carbapenem,whosetotal resistance rate was below 4.0%.The resistance rates of A.baumannii to most surveillance drugs in cludingimipenem were above 50.0% and theisolates of P.aeruginosa were still highly susceptible to most surveillancedrugs.Conclusion It is severe that the situation of bacterial drug resistance in blood culture in Shaanxi province.Should fullyuse bacterial drug resistance surveillance results for supervision and administration,and take effective measures forcontrolling the spread of resistant isolates.

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备注/Memo

备注/Memo:

作者简介:归巧娣(1978-),女,硕士研究生,副主任医师,主要从事临床微生物和细菌耐药研究,Tel:13649200365。
通讯作者:乔 军(1964-),女,本科,副主任检验技师,研究方向:实验室管理,E-mail:bbyan@qq.com。
更新日期/Last Update: 2016-10-30