[1]洪毅.不规则抗体致新生儿溶血病换血治疗的研究分析[J].现代检验医学杂志,2016,31(06):135-137.[doi:10.3969/j.issn.1671-7414.2016.06.040]
　HONG Yi.Analysis of Irregular Antibodies Induced by Treatment of Neonatal Hemolysis[J].Journal of Modern Laboratory Medicine,2016,31(06):135-137.[doi:10.3969/j.issn.1671-7414.2016.06.040]
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不规则抗体致新生儿溶血病换血治疗的研究分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年06期
页码:
135-137
栏目:
检验与临床
出版日期:
2016-12-20

文章信息/Info

Title:
Analysis of Irregular Antibodies Induced by Treatment of Neonatal Hemolysis
作者:
洪毅
陕西西安高新医院输血科,西安 710075
Author(s):
HONG Yi
Department of Blood Transfusion,Xi'an High Tech Hospital,Xi'an 710075,China
关键词:
不规则抗体;  新生儿溶血病;  换血治疗
分类号:
R722.18; R457.1
DOI:
10.3969/j.issn.1671-7414.2016.06.040
文献标志码:
A
摘要:
目的 对由ABO以外不规则抗体引起新生儿溶血病(HDN)的换血治疗进行分析研究,并探讨其临床诊疗意义。方法 收集2010～2015年在西安高新医院进行新生儿溶血病实验样本2 311例,用微柱凝胶卡抗球蛋白法筛查不规则抗体,Liss-IAT试管法鉴定不规则抗体; 分析不规则抗体的种类和相关临床资料; 换血后的疗效观察。结果 在2 311例新生儿溶血病样本中共检出不规则抗体36例,检出率占1.56%。其中Rh血型系统、Lewis血型系统、Kidd血型系统、Diego血型系统分别检出28例、3例、4例和1例,阳性率分别为:77.78%,8.33%,11.11%和2.78%; 在Rh血型系统的不规则抗体28例中,抗-D、抗-E、抗-cE、抗-C和抗-Ce分别检出2例,8例,11例,2例和5例,各抗体所占的百分率分别为:7.14%,28.57%,39.29%,7.14%和17.86%; 换血前后血红蛋白、游离胆红素用t检验,换血前后血红蛋白明显升高,游离胆红素明显降低,差异具有统计学意义,其中有26例进行了换血治疗。结论不规则抗体易致严重的新生儿溶血病,在检测中应采用敏感的方法,对临床进行换血治疗有重要的指导作用。
Abstract:
Objective To cause hemolytic disease of the newborn to the outside by ABO irregular antibody(HDN)of the exchange transfusiontherapy,and explore its clinical significance.Methods Collected 2 311 cases of neonatal hemolytic disease in Xi'an High Tech Hospitalfrom 2010 to 2015.The irregular antibody was screened by antiglobulin method ofmicro column gel card and identifed by Liss-IAT tube method.Then analysed thetypes of irregular antibodies and related clinical data and curative effect after treatmentfor.Results In 2 311 cases of neonatal hemolytic disease samples,36 cases of irregular antibodies were detected 1.56% of the detection rate.In Rh system,Lewis system,Kidd system,Diego system were detected in 28 cases,3 cases,4 cases and 1 cases,the positive rates were 77.78%,8.33%,11.11%,2.78%; Rh blood group system in irregular antibody in 28 cases,anti-D,anti-E,anti-cE,anti-C,anti-Ce were detected in 2 cases,8 cases,11 cases,2 cases,5 cases,the percentage of each antibody accounted forrespectively 7.14%,28.57%,39.29%,7.14% and 17.86%.Before and after exchange transfusion hemoglobin t,with free bilirubin test before and after thetransfusion hemoglobin was significantly higher in free bilirubin decreased significantly,the difference was statistically significant,of which 26 cases of exchange transfusion treatment.Conclusion Irregular antibody may cause serious hemolytic disease of the newborn,should be used in the detection of sensitive methods in clinical practice have an important role in exchange transfusion.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:洪 毅(1975-),男,本科,主管技师,现从事输血管理及输血检验,Tel:13991933029,E-mail:1967113703@qq.com。
更新日期/Last Update: 2016-12-20