[1]王丽娜,葛君琍,郭苗.宝鸡地区成年健康人群血清胱抑素C参考区间调查[J].现代检验医学杂志,2016,31(06):141-142，146.[doi:10.3969/j.issn.1671-7414.2016.06.042]
　WANG Li-na,GE Jun-li,GUO Miao.Investigation of Reference Range of Serum Cystatin C of Healthy People in Baoji[J].Journal of Modern Laboratory Medicine,2016,31(06):141-142，146.[doi:10.3969/j.issn.1671-7414.2016.06.042]
点击复制

宝鸡地区成年健康人群血清胱抑素C参考区间调查()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年06期
页码:
141-142，146
栏目:
检验与临床
出版日期:
2016-12-20

文章信息/Info

Title:
Investigation of Reference Range of Serum Cystatin C of Healthy People in Baoji
作者:
王丽娜1; 葛君琍2; 郭苗2
1.宝鸡市中心医院老年病科,陕西宝鸡 721008; 2.宝鸡高新人民医院检验科,陕西宝鸡 721013
Author(s):
WANG Li-na1; GE Jun-li2; GUO Miao2
1.Department of Geriatrics,Central Hospital of Baoji,ShaanxiBaoji 721008,China; 2.Department of Clinical Laboratory,Baoji High-Tech People's Hospital,Shaanxi Baoji 721013,China
关键词:
胱抑素C(Cys-C);  参考区间;  健康人群;  颗粒增强散射免疫比浊法
分类号:
R446.112
DOI:
10.3969/j.issn.1671-7414.2016.06.042
文献标志码:
A
摘要:
目的 建立宝鸡地区成人血清胱抑素C(Cys-C)的参考区间。方法 对健康成人男性720例、女性722例采集静脉血标本,采用颗粒增强散射免疫比浊法测定其血清Cys-C的浓度。结果 宝鸡地区健康成年人Cys-C水平男性高于女性(t=11.625,P<0.05)。男性、女性Cys-C水平均随年龄升高而增高(男:F=48.908,P<0.05; 女:F=59.801,P<0.05)。该地区健康人群血清Cys-C的参考区间男性:44岁以下为0.56～0.98 mg/L,45～59岁为0.59～1.08 mg/L,60～74岁为0.69～1.24 mg/L,75岁以上为0.72～1.28 mg/L; 女性:44岁以下为0.52～0.98 mg /L,45～59岁为0.56～0.99 mg/L,60～74岁为0.59～1.12 mg/L,75岁以上为0.69～1.22 mg/L。结论 健康人群血清Cys-C浓度存在着年龄和性别差异,应建立自己实验室健康人群血清Cys-C的参考范围。
Abstract:
Objective To established reference range of serum cystatin C(Cys-C)by the investigated data from healthy people in baoji.Methods Venous blood samples from healthy adults of male 720cases and female 722 cases were collected,and then they were detected serum cystatin Cys-C by particle-enhanced nephelometric immunoassay method.Results The mean of serum Cys-C of healthy adults men was higherthan women's(t=11.625,P<0.05).The levels of serum Cys-C of male andfemale increase with age(male:F=48.908,P<0.05; female:F=59.801,P<0.05).The serum Cys-C level's reference intervals of healthy adults in Baoji were as following:male:0.56～0.98 mg /L(≤44 years),0.59～1.08 mg/L(45～59 years),0.69～1.24 mg /L(60～74 years),0.72～1.28 mg/L(≥75 years); female:0.52～0.98 mg/L(≤44 years),0.56～0.99 mg/L(45～59 years),0.59～1.12 mg/L(60～74 years),0.69～1.22 mg/L(≥75 years).Conclusion The level of serum Cys-C of healthy adults was a significant difference between age and gender.So every laboratory should establish theirown reference range of serum Cys-C.

参考文献/References:

[1] 魏崇莉,何东元.胱抑素C的临床意义及其应用进展[J].国际检验医学杂志,2012,33(2):182-183. Wei CL,He DY.The clinical significance of serum cystatin C and itsapplication progress [J].Int J Lab Med,2012,33(2):182-183.
[2] 王淑娟,张 敏,韩玉芳,等.豫北地区血清胱抑素C,尿素的参考范围调查[J].中国误诊学杂志,2011,11 (10):2519-2520,2529. Wang SJ,Zhang M,Han YF et al.Investigation of serum cystatin C and urea reference ranges in the north area of Henan province[J].Chin J Misdiagn,2011,11(10):2519-2520,2529.
[3] Jones G,Barker A.Reference intervals[J].Clin Biochem Rev,2008,29(suppl 1):S93-97.
[4] 胡全修,戴晓强.胶乳增强免疫透射比浊法测定血清胱抑素C的方法学评价[J].检验医学与临床,2011,8 (22):2775-2777. Hu QX,Dai XQ.Evaluation of particle-enhanced tra-nsmitted turbidimetric immunoassay for determination of serum cystatin C[J].Lab Med Clin,2011,8(22):2775-2777.
[5] Randers E,Erlandsen EJ.Serum cystatin C as an endogenous maker of the rena1 function a review[J].Clin Chem Led Med,1999,37(4):389-395.
[6] 李 昕,韩鸿玲,贾海员,等.应用颗粒增强透射免疫比浊法测定血清胱抑素C的探讨[J].天津医科大学学 报,2008,14(2):195-196,247. Li X,Han HL,Jia HY,et al.Study of particle-enhanced transmittedturbidimetric immunoassay of serum cystatin C[J].Journal of Tianjin MedicalUniversity,2008,14(2):195-196,247.
[7] 林勇平,彭淑莹,刘忠民.血清胱抑素C参考区间的建立及其应用[J].广州医学,2012,33(13):1954-1956. Lin YP,Peng SY,Liu ZM.The establishment and application of serum cystatin C reference ranges[J].Guangdong Medical Journal,2012,33(13):1954-1956.
[8] 尚 红,王毓三,申子瑜.全国临床检验操作规程[S].4版.北京:人民卫生出版社,2015:311. Shang H,Wang YS,Shen ZY.National guide to clinical laboratory procedures[S].4th Ed.Beijing:People's Medical Publishing House,2015:311.

相似文献/References:

[1]章晓燕,王 薇,何法霖,等.全国网织红细胞计数 参考区间和决定限现状调查与分析[J].现代检验医学杂志,2016,31(03):158.[doi:10.3969/j.issn.1671-7414.2016.03.045]
　ZHANG Xiao-yan,WANG Wei,HE Fa-lin,et al.Investigation and Analysis of Reference Intervals and Decision Limits of Reticulocyte Count in China[J].Journal of Modern Laboratory Medicine,2016,31(06):158.[doi:10.3969/j.issn.1671-7414.2016.03.045]
[2]钟 堃,王 薇,何法霖,等.国内临床化学9项常规项目参考区间与即将发布的卫生行业标准的比较和分析[J].现代检验医学杂志,2015,30(03):38.[doi:10.3969/j.issn.1671-7414.2015.03.011]
　ZHONG Kun,WANG Wei,HE Fa-lin,et al.Comparison and Analysis of the Reference Intervals of 9 Serum Routine Chemical Analytes between the Current Application of Clinical Laboratories and the Latest Health Industrial Standards Draft for Approval[J].Journal of Modern Laboratory Medicine,2015,30(06):38.[doi:10.3969/j.issn.1671-7414.2015.03.011]
[3]钟 堃,王 薇,何法霖,等.半胱氨酸蛋白酶抑制剂C和β2微球蛋白参考区间的调查与分析[J].现代检验医学杂志,2015,30(04):32.[doi:10.3969/j.issn.1671-7414.2015.04.008]
　ZHONG Kun,WANG Wei,HE Fa-lin,et al.Investigation and Analysis of Reference Intervals of Cystatin C and β2-Microglobulin[J].Journal of Modern Laboratory Medicine,2015,30(06):32.[doi:10.3969/j.issn.1671-7414.2015.04.008]
[4]钟 堃,王 薇,何法霖,等.全国231家临床实验室23项干化学 与湿化学检验项目参考区间的比较和分析[J].现代检验医学杂志,2015,30(01):145.[doi:10.3969/j.issn.1671-7414.2015.01.044]
　ZHONG Kun,WANG Wei,HE Fa-lin,et al.Comparison of the Reference Intervals of 23 Analytes between Wet Chemistry and Dry Chemistry in 231 Clinical Laboratories in China[J].Journal of Modern Laboratory Medicine,2015,30(06):145.[doi:10.3969/j.issn.1671-7414.2015.01.044]
[5]乔 军,毛华杰,白家瑞,等.西安地区同型半胱氨酸参考区间的初步建立[J].现代检验医学杂志,2016,31(05):130.[doi:10.3969/j.issn.1671-7414.2016.05.037]
　QIAO Jun,MAO Hua-jie,BAI Jia-rui,et al.Investigation on Serum Homocysteine for Reference Range in Xi'an[J].Journal of Modern Laboratory Medicine,2016,31(06):130.[doi:10.3969/j.issn.1671-7414.2016.05.037]
[6]何金泉,吴彩明,李国强.广东虎门地区健康人群低血红蛋白密度(LHD%)参考区间的建立和临床应用[J].现代检验医学杂志,2017,32(02):86.[doi:10.3969/j.issn.1671-7414.2017.02.023]
　HE Jin-quan,WU Cai-ming,LI Guo-qiang.Building the Reference Range of Low Hemoglobin Density(LHD%) of Healthy Population in Humen District of Guangdong and Discuss Its Clinical Application Value[J].Journal of Modern Laboratory Medicine,2017,32(06):86.[doi:10.3969/j.issn.1671-7414.2017.02.023]
[7]卢美红,鞠少卿,丛 辉,等.南通地区健康人群血清NSE电化学发光法检测参考区间的调查[J].现代检验医学杂志,2018,33(04):59.[doi:10.3969/j.issn.1671-7414.2018.04.015]
　LU Mei-hong,JU Shao-qing,CONG Hui,et al.Investigate of Serum NSE Reference Range of Healthy People in Nantong with Electrochemiluminescence[J].Journal of Modern Laboratory Medicine,2018,33(06):59.[doi:10.3969/j.issn.1671-7414.2018.04.015]
[8]刘纯岳,林帝金,方俊粤,等.健康成年人血清α-L-岩藻糖苷酶参考区间的建立及适用性评价[J].现代检验医学杂志,2018,33(05):102.[doi:10.3969/j.issn.1671-7414.2018.05.027]
　LIU Chun-yue,LIN Di-jin,FANG Jun-yue,et al.Establishment and Applicability Evaluation of Reference Interval for Serum AFU of Healthy Adults[J].Journal of Modern Laboratory Medicine,2018,33(06):102.[doi:10.3969/j.issn.1671-7414.2018.05.027]
[9]肖光军,刘艳婷,杨 洪,等.四川省遂宁地区表观健康成年人群血浆FMN,FMN/TP比值及FMN/ALB比值参考区间的建立[J].现代检验医学杂志,2019,34(02):56.[doi:10.3969/j.issn.1671-7414.2019.02.015]
　XIAO Guang-jun,LIU Yan-ting,YANG Hong,et al.Establishment of Reference Interval for PlasmaFMN,FMN/TP and FMN/ALB Value among Apparently HealthyAdult Population in Suining of Sichuan[J].Journal of Modern Laboratory Medicine,2019,34(06):56.[doi:10.3969/j.issn.1671-7414.2019.02.015]
[10]张 勇,刘 婧,扈会整,等.陕西省咸阳地区正常人群尿液有形成分参考区间的建立[J].现代检验医学杂志,2019,34(03):112.[doi:10.3969/j.issn.1671-7414.2019.03.027]
　ZHANG Yong,LIU Jing,HU Hui-zheng,et al.Establishment of A Reference Interval for Urine Formationin Healthy People in Xianyang Region,Shaanxi Province[J].Journal of Modern Laboratory Medicine,2019,34(06):112.[doi:10.3969/j.issn.1671-7414.2019.03.027]

备注/Memo

备注/Memo:
作者简介:王丽娜(1981-),女,硕士,副主任医师,主要从事老年病临床工作,E-mail:vissanss2003@ 126.com。 通讯作者:葛君琍(1958-),女,主任检验师,主要从事临床医学检验工作,E-mail:gjljyk@126.com。
更新日期/Last Update: 2016-12-20