[1]王 坤,贾兴旺,董 矜,等.血清脂蛋白相关磷脂酶A2和胱抑素C联合检测对SLE患者并发狼疮性肾炎的风险评估[J].现代检验医学杂志,2017,32(04):6-8,11.[doi:10.3969/j.issn.1671-7414.2017.04.002]
 WANG Kun,JIA Xing-wang,DONG Jin,et al.Risk Assessment of Combined Detection of Lipoprotein Associated Phospholipase A2 and Cystatin C for Lupus Nephritis in Patients with Systemic Lupus Erythematosus[J].Journal of Modern Laboratory Medicine,2017,32(04):6-8,11.[doi:10.3969/j.issn.1671-7414.2017.04.002]
点击复制

血清脂蛋白相关磷脂酶A2和胱抑素C联合检测对SLE患者并发狼疮性肾炎的风险评估()
分享到:

《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年04期
页码:
6-8,11
栏目:
论著
出版日期:
2017-07-25

文章信息/Info

Title:
Risk Assessment of Combined Detection of Lipoprotein Associated Phospholipase A2 and Cystatin C for Lupus Nephritis in Patients with Systemic Lupus Erythematosus
文章编号:
1671-7414(2017)04-006-04
作者:
王 坤贾兴旺董 矜颜光涛
解放军总医院生化科,北京 100853
Author(s):
WANG KunJIA Xing-wangDONG JinYAN Guang-tao
Department of Clinical Biochemistry,PLA General Hospital,Beijing 100853,China)Abstract:Objective To investigate the value of combinedevaluation of serum lipoprotein associated phospholipase A2(LP-PLA2)and cystatin C(CysC)on systemic lupus erythematosus(SLE
关键词:
脂蛋白相关磷脂酶A2 胱抑素C 系统性红斑狼疮 狼疮性肾炎
分类号:
R446.112; R593.24
DOI:
10.3969/j.issn.1671-7414.2017.04.002
文献标志码:
A
摘要:
目的 探讨血清脂蛋白相关磷脂酶A2(LP-PLA2)与胱抑素C(CysC)联合检测在系统性红斑狼疮(SLE)患者中并发狼疮性肾炎的应用价值。方法收集2016年6月~2017年2月在解放军总医院住院的SLE患者177例,其中肾脏不受累的患者87例,狼疮性肾炎(LN)患者90例,收集年龄性别匹配的健康查体人员60例,分别记为狼疮组(SLE组)、狼疮性肾炎组(LN组)和对照组。检测各组标本LP-PLA2的活性水平和CysC浓度,做ROC曲线确立SLE患者并发LN时两指标的临界值,比较不同诊断标准的检验效能。结果 LN组LP-PLA2活性水平和CysC浓度比SLE组高,差异具有统计学意义(Z=-2.512,-5.688; P<0.05); 在SLE患者并发LN的风险评估上,LP-PLA2的临界值取245.5 U/L, CysC的临界值取1.235 mg/L,并且采用并联方式进行风险评估时,其敏感度和阴性预测值会比单独使用CysC评估时显著提高(χ2=9.461,4.377; P<0.05),检验准确度最高。结论 血清LP-PLA2和CysC联合检测并采用并联方式在对SLE患者并发LN的风险评估上具有一定的临床应用价值。
Abstract:
patients with lupus erythematosus.Methods A total of 177 patients with SLE were enrolled in the General Hospital of People's Liberation Army from June 2000 to February 2017,87 cases in lupus group(SLE group),90 cases in lupus nephritis group(LN group), 60 cases in healthy control group.The concentration of LP-PLA2and CysC were measured.The ROC curves was established for estimation of the cutoff values of two indexes in SLE patients with LN,and the diagnostic efficacy of different diagnostic criteria was compared.Results TheLP-PLA2 and CysC concentration in the LN group were higher than those in the SLE group(Z=-2.512,-5.688,all P<0.05).The cutoff value of LP-PLA2 was 245.5 U/L and the cutoff value of CysC was 1.235 mg/L on the risk assessment of in SLE patients with LN.When using the parallel method for combined LP-PLA2 and CysC to evaluate the risk of LN,the sensitivity and negative predictive value would be significantly improved(χ2=9.461,4.377,all P<0.05),the efficiency was better.Conclusion Parallel assessment of serum LP-PLA2 and CysC have clinical value on assessment of the riskof LN in SLE patients.

参考文献/References:

[1] Riveros Frutos A,Casas I,Rua-Figueroa I,et al.Systemic lupuserythematosus in Spanish males:a study of the Spanish Rheumatology Society Lupus Registry(Relesser)cohort[J].Lupus,2017,26(7):698-706.
[2] Almaani S, Meara A, Rovin BH.Update on Lupus Nephritis[J].Clin J Am Soc Nephrol,2017,12(5):825-835.
[3] Peixoto L,Aguiar P,De Braganca R,et al.Cystatin C:A promising markerof renal function in patients with systemic lupus erythematosus?[J].Acta MedPort,2015,28(3):333-341.
[4] 高 科,陶 娟,范 宁,等.联合检测三种生化指标对糖尿病肾病早期诊断的临床价值分析[J].现代检验医学杂志,2016,31(4):117-120. Gao K,Tao J,Fan N,et al.Analysis of combined detection of threekinds of biochemical indexes of clinical value for early diagnosis of diabetic nephropathy[J].J Mod Lab Med,2016,31(4):117-120.
[5] Garg PK,Mcclelland RL,Jenny NS,et al.Lipoprotein-associated phospholipase A2 and risk of incident cardiovascular disease in a multi-ethnic cohort:the multi ethnic study of atherosclerosis[J].Atherosclerosis,2015,241(1):176-182.
[6] Younus A,Humayun C,Ahmad R,et al.Lipoprotein-associated phospholipase A2 and its relationship with markers of subclinical cardiovascular disease:Asystematic review[J].J Clin Lipidol,2017,11(2):328-337.
[7] Wang C,Fang X,Hua Y,et al.Lipoprotein-associated phospholipase A2 and risk of carotid atherosclerosis and cardiovascular events in community-basedolder adults in China[J].Angiology,2017,6(11):45-54.
[8] 文关良,剌 梅.脂蛋白相关磷脂酶A2在颈动脉斑块性脑梗死中的临床意义[J].现代检验医学杂志,2017,32(2):117-118,122. Wen GL,La M.Clincal study of LP-PLA2 in carotid plaques cerebralinfarction patients[J].J Mod Lab Med,2017,32(2):117-118,122.
[9] Ulrich C,Trojanowicz B,Fiedler R,et al.Differential expression of lipoprotein-associated phospholipase A2 in monocyte subsets:impact ofuremia and atherosclerosis[J].Nephron,2017,135(3):231-241.
[10] Wang Y,Li SS,Na SP,et al.Characterization of lipoprotein-associated phospholipase A2 in serum in patients with stage 3~5 chronic kidney disease[J].Am J Med Sci,2016,352(4):348-353.
[11] 袁学华,张薇薇,李权伦,等.血清视黄醇结合蛋白、胱抑素C及β2微球蛋白的联合检测在妊娠期糖尿病早期肾损害诊断中的临床意义[J].现代检验医学杂志,2017,32(2):106-109. Yuan XH,Zhang WW,Li QL,et al.Clinical significance of combined detection of serum retinal-binding protein,cystatin C and β2-micoglobuimin in diagnosis of early renal injures of gestational diabetes mellitus[J].J Mod Lab Med,2017,32(2):106-109.
[12] Jacobs A,Benraad C,Wetzels J,et al.Clinical relevance of differencesin glomerular filtration rate estimations in frail older people by creatinine-vs cystatin C-based formulae[J].Drugs Aging,2017,34(6):445-452.
[13] Volpon LC, Sugo EK, Carlotti AP.Diagnostic and prognostic value of serum cystatin C in critically ill children with acute kidney injury[J].Pediatr Crit Care Med,2015,16(5):125-131.
[14] Asilioglu N,Acikgoz Y,Paksu MS,et al.Is serum cystatin C a better marker than serum creatinine for monitoring renal function in pediatric intensivecare unit?[J].J Trop Pediatr,2012,58(6):429-434.
[15] Murty MS, Sharma UK, Pandey VB,et al.Serum cystatin C as a marker of renal function in detection of early acute kidney injury[J].Indian J Nephrol,2013,23(3):180-183.
[16] Ferguson JF,Hinkle CC,Mehta,et al.Translational studies of lipoprotein-associated phospholipase A(2)in inflammation and atherosclerosis[J].J AmColl Cardiol,2012,59(8):764-772.
[17] 姚创利,赵 佳,鲁旭娟,等.冠心病患者血清脂蛋白相关磷脂酶A2水平与锰超氧化物歧化酶9 Ala/Val基因多态性关系探讨[J].现代检验医学杂志,2017,32(1):26-29.
Yao CL,Zhao J,Lu XJ,et al.Study on the relationship between lipoproteinassociated phospholipase A2 level and manganese superoxide dismutase 9 Ala/valgenetic polymorphism in patients with coronary heart disease[J].J Mod Lab Med,2017,32(1):26-29.
[18] 阿尔孜古丽·吐尔逊,努尔比亚·阿布都热西提,田刚.脂蛋白相关性磷脂酶A2与冠心病的关系研究[J].现代检验医学杂志,2014,29(4):65-66,70.
[19] Szabo MZ,Szodoray P,Kiss E.Dyslipidemia in systemic lupus erythematosus[J].Immunol Res,2017,65(2):543-550.
[20] Tellis CC,Tselepis AD.Pathophysiological role and clinical significance of lipoprotein-associated phospholipase A2(Lp-PLA2)bound to LDL and HDL[J].Curr Pharm Des,2014,20(40):6256-6269.

相似文献/References:

[1]张允奇a,陆学东b,张银辉b,等.SLE患者血清胱抑素C与血脂的相关性分析[J].现代检验医学杂志,2015,30(04):63.[doi:10.3969/j.issn.1671-7414.2015.04.017]
 ZHANG Yun-qia,LU Xue-dongb,ZHANG Yin-huib,et al.Correlation Analysis of Serum Cystatin C and Lipids Levels in Patients with Systemic Lupus Erythematosus[J].Journal of Modern Laboratory Medicine,2015,30(04):63.[doi:10.3969/j.issn.1671-7414.2015.04.017]
[2]洪骏,王锋,印中鹏,等.冠心病患者血浆纤维蛋白原与脂蛋白相关磷脂酶A2水平[J].现代检验医学杂志,2015,30(05):6.[doi:10.3969/j.issn.1671-7414.2015.05.003]
 HONG Jun,WANG Feng,YIN Zhong-peng,et al.Levels of Plasma Lipoprotein Associated Phospholipase A2 and Fibrinogen in Patients with Coronary Artery Disease[J].Journal of Modern Laboratory Medicine,2015,30(04):6.[doi:10.3969/j.issn.1671-7414.2015.05.003]
[3]杨渝伟,黄玉霞,陈小红,等.胱抑素C及其eGFR方程在诊断肝硬化患者肾损害中的应用[J].现代检验医学杂志,2016,31(04):24.[doi:10.3969/j.issn.16717-414.2016.04.006]
 YANG Yu-wei,HUANG Yu-xia,CHEN Xiao-hong,et al.Clinical Application of Cystatin C and It's eGFR Equation for Diagnosing Kidney Injure in Patients with Liver Cirrhosis[J].Journal of Modern Laboratory Medicine,2016,31(04):24.[doi:10.3969/j.issn.16717-414.2016.04.006]
[4]高 科,陶 娟,范 宁,等.联合检测三种生化指标对糖尿病肾病早期诊断的临床价值分析[J].现代检验医学杂志,2016,31(04):117.[doi:10.3969/j.issn.1671-7414.2016.04.033]
 GAO Ke,TAO Juan,FAN Ning,et al.Analysis of Combined Detection of Three Kinds of Biochemical Indexes of Clinical Value for Early Diagnosis of Diabetic Nephropathy[J].Journal of Modern Laboratory Medicine,2016,31(04):117.[doi:10.3969/j.issn.1671-7414.2016.04.033]
[5]唐四海.慢性乙型肝炎患者血清胱抑素C水平与其肝损伤程度的关系[J].现代检验医学杂志,2016,31(04):146.[doi:10.3969/j.issn.1671-7414.2016.04.042]
 TANG Si-hai.Relationship between the Level of Serum Cystatin C and Degree of Liver Damage in Patients with Chronic Hepatitis B[J].Journal of Modern Laboratory Medicine,2016,31(04):146.[doi:10.3969/j.issn.1671-7414.2016.04.042]
[6]姚创利,赵 佳,鲁旭娟,等.冠心病患者血清脂蛋白相关磷脂酶A2水平与锰超氧化物歧化酶9 Ala/Val基因多态性关系探讨[J].现代检验医学杂志,2017,32(01):26.[doi:10.3969/j.issn.1671-7414.2017.01.008]
 YAO Chuang-li,ZHAO Ja,LU Xu-juan,et al.Study on the Relationship between Lipoprotein Associated Phospholipase A2 Level and Manganese Superoxide Dismutase 9 Ala/Val Genetic Polymorphism in Patients with Coronary Heart Disease[J].Journal of Modern Laboratory Medicine,2017,32(04):26.[doi:10.3969/j.issn.1671-7414.2017.01.008]
[7]朱 娜a,张利侠b,张 华b,等.血清四项生化指标联合检测在狼疮肾炎患者早期肾损伤的临床意义[J].现代检验医学杂志,2017,32(02):114.[doi:10.3969/j.issn.1671-7414.2017.02.031]
 ZHU Naa,ZHANG Li-xiab,ZHANG Huab,et al.Clinical Significance of Serum Bun,Cr,Cys C and RBP Combined Detection for Early Diagnosis of Renal Damage in Patlents with Lupus Nephritis[J].Journal of Modern Laboratory Medicine,2017,32(04):114.[doi:10.3969/j.issn.1671-7414.2017.02.031]
[8]文关良,剌 梅.脂蛋白相关磷脂酶A2在颈动脉斑块性脑梗死中的临床意义[J].现代检验医学杂志,2017,32(02):117.[doi:10.3969/j.issn.1671-7414.2017.02.032]
 WEN Guan-liang,LA Mei.Clinical Study of LP-PLA2 in Carotid Plaques Cerebral Infarction Patients[J].Journal of Modern Laboratory Medicine,2017,32(04):117.[doi:10.3969/j.issn.1671-7414.2017.02.032]
[9]李 薪,魏力强.2型糖尿病患者血清中脂蛋白相关磷脂酶A2检测的临床意义[J].现代检验医学杂志,2017,32(06):85.[doi:10.3969/j.issn.1671-7414.2017.06.001]
 LI Xin,WEI Li-qiang.Clinical Significance of Detection of Lipoprotein Associated Phospholipase A2 in Serum of Patients with Type 2 Diabetes Mellitus[J].Journal of Modern Laboratory Medicine,2017,32(04):85.[doi:10.3969/j.issn.1671-7414.2017.06.001]
[10]王丹晨,侯立安,国秀芝,等.改良后的长春恒晓脂蛋白相关磷脂酶A2活性检测试剂性能验证[J].现代检验医学杂志,2018,33(04):134.[doi:10.3969/j.issn.1671-7414.2018.04.037]
 WANG Dan-chen,HOU Li-an,GUO Xiu-zhi,et al.Performance Verification of Improved Lipoprotein-associated Phospholipase A2 Detection Reagent of Changchun Hengxiao Co.,Ltd.[J].Journal of Modern Laboratory Medicine,2018,33(04):134.[doi:10.3969/j.issn.1671-7414.2018.04.037]

备注/Memo

备注/Memo:
基金项目:国家科技支撑计划(2015BAK45B01)。 作者简介:王 坤(1988-),男,在读硕士,E-mail:wangkunhjj@aliyun.com。 通讯作者:颜光涛(1960-),男,主任,研究员,博士生导师,E-mail:yan301@263.net。
更新日期/Last Update: 1900-01-01