[1]汪海瑛,杨金光,李红霞.孕妇血清L-精氨酸水平检测对妊高症的预测价值分析[J].现代检验医学杂志,2017,32(04):52-56.[doi:10.3969/j.issn.1671-7414.2017.04.015]
　WANG Hai-ying,YANG Jin-guang,LI Hong-xia.Predictive Value of Detecting Serum L-Arginine Levels in Pregnant Woman with PIH[J].Journal of Modern Laboratory Medicine,2017,32(04):52-56.[doi:10.3969/j.issn.1671-7414.2017.04.015]
点击复制

孕妇血清L-精氨酸水平检测对妊高症的预测价值分析()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年04期
页码:
52-56
栏目:
论著
出版日期:
2017-07-25

文章信息/Info

Title:
Predictive Value of Detecting Serum L-Arginine Levels in Pregnant Woman with PIH
文章编号:
1671-7414(2017)04-052-05
作者:
汪海瑛1; 杨金光1; 李红霞2
1.安康市中心医院产科,陕西安康 725000; 2.延安大学附属医院妇科,陕西延安 716000
Author(s):
WANG Hai-ying1; YANG Jin-guang1; LI Hong-xia2
1.Department of Obstetrical, Ankang City Central Hospital,Shaanxi Ankang 725000,China; 2.Departmentof Gynecology, Affiliated Hospital of Yan'an University,Shaanxi Yan'an 716000,China
关键词:
妊高症;  血清L-精氨酸;  妊娠期;  ROC曲线
分类号:
R714.246; R446.112
DOI:
10.3969/j.issn.1671-7414.2017.04.015
文献标志码:
A
摘要:
目的 评估血清L-精氨酸的浓度在预测妊娠期高血压症(pregnancy induced hypertension,PIH)发展中是否起到作用,分析其作为临床预测指标的有效性。方法 研究共纳入186例妊娠期孕妇,出现妊娠期高血压症(PIH)的孕妇为实验组,健康孕妇为对照组,对其进行回顾性调查研究,对比健康孕妇和妊娠期高血压症孕妇(PIH)在妊娠期不同阶段血清L-精氨酸以及脐带血血清L-精氨酸的浓度,分析血清L-精氨酸和脐带血血清L-精氨酸在妊娠期高血压发展中的诊断效能。结果 实验组和对照组受试者在年龄(χ2=2.426,P=0.119; t=1.218,P=0.229)和妊娠前吸烟(χ2=2.088,P=0.148)方面差异无统计学意义,但两组患者的BMI(χ2=8.772,P=0.003)和孕产次(χ2=6.083,P=0.014)差异有统计学意义。两组受试者妊娠不同阶段的血清L-精氨酸的浓度差异无统计学意义,且脐带血血清L-精氨酸的浓度差异也无统计学意义。孕产次不同的受试者,脐带血血清L-精氨酸的浓度差异有统计学意义,年龄,BMI和以及是否吸烟等特征不同的受试者,血清L-精氨酸浓度和脐带血血清L-精氨酸浓度无显著差异。血清L-精氨酸浓度和脐带血血清L-精氨酸浓度的ROC曲线分析结果显示,其对妊娠期高血压的诊断效能较低。结论 妊娠期孕妇L-精氨酸水平与PIH的发展与BMJ和孕产次存在相关性。但由于样本量限制,L-精氨酸对PIH的诊断效能分析还需要更进一步研究确定。
Abstract:
Objective The evaluate action of serum L-arginine levels for predicting development of pregnant women with PIH,and analyze its effectiveness as clinical predictor.Methods Collecting 186patients was performed a retrospective study.The PIH pregnant women was the experiment group,and the health pregnant women was the control group.In order toanalyse the effect,the levels of L-arginine were measured in the early,middle and late period of pregnant women.Compared with the serum L-arginine in different groups with χ2-test and t-test based on data type.Results Experimental group and control group subjects in age(χ2=2.426,P=0.119; t=1.218,P=0.229)and smoking before pregnancy(χ2=2.088,P=2.088),there was no significant differences,but the two groupsof patients with BMI(χ2=8.772,P=0.003)and parity(χ2=6.083,P=0.014)was statistically.In different stages of pregnancy,the concentration of serum L-arginine had no statistical differences,and in the concentrationof umbilical cord blood,serum L-arginine also had no statistical difference.There was a statistical differences in the serum L-arginine concentration of thecord blood for different number of pregnancies,but the concentrations of L-arginine in cord blood and in serum L-arginine.There were no significant differencein age,BMI and smoking pregnant.According to ROC curve analysis,for the diagnostic of concentration in serum L-arginine and in umbilical cord blood,the results indicate low efficiency to the diagnosis of pregnancy hypertension during pregnancy.Conclusion L-arginine level and the development of PIH and body mass index and maternal correlation for the pregnant women.Because the sample size limitations,L-arginine in the diagnosis of PIH also needs to be further research to determine the effectiveness of predicting.

参考文献/References:

[1] Roberts BW,Mitchell J,Kilgannon JH,et al.Nitric oxide donor agents for the treatment of ischemia/reperfusion injury in human subjects:a systematic review[J].Shock,2013,39(3):229-239.
[2] Khalil A,Hardman L,O'Brien P.The role of arginine,homoarginine and nitric oxide in pregnancy[J].Amino Acids,2015,47(9):1715-1727.
[3] Kintiraki E,Papakatsika S,Kotronis G,et al.Pregnancy-induced hypertension[J].Hormones(Athens Greece),2015,14(2):211-223.
[4] 潘秀林,朱玩秀.妊高症患者血清CysC,HCY及mALB联合检测的临床意义[J].现代检验医学杂志,2015,30(3):145-146,150. Pan XL,Zhu WX.Clinical significance of serum Cys C,HCY and mALB joint detection to HDCP patients[J].J Mod Lab Med,2015,30(3):145-146,150.
[5] Hristina K,Langerholc T,Trapecar M.Novel metabolic roles of L-arginine in body energy metabolism and possible clinical applications[J].The Journalof Nutrition,Health & Aging,2014,18(2):213-218.
[6] Tamás P,Bódis J,Sulyok E,et al.L-arginine metabolism in early-onset and late-onset pre-eclamptic pregnancies[J].Scandinavian Journal of Clinical and Laboratory Investigation,2013,73(5):436-443.
[7] 王忠民,汪洁萍,叶 萍.L-精氨酸对妊高征的治疗作用及其机制的探讨[J].微循环学杂志,2004,14(1):31-33. Wang ZM,Wang JP,Ye Ping.Effect and mechanism of L-Arginine in treating pregnancy induced hypertension syndrome[J].Chinese Journal of Microcirculation,2004,14(1):31-33.
[8] Sobczak A,Prokopowicz A,Radek M,et al.Tobacco smoking decreases plasma concentration of the emerging cardiovascular risk marker,L-homoarginine[J].Circulation Journal,2014,78(5):1254-1258.
[9] Dorniak-Wall T,Grivell RM,Dekker GA,et al.The role of L-arginine inthe prevention and treatment of pre-eclampsia:a systematic review of randomised trials[J].Journal of Human Hypertension,2014,28(4):230-235.
[10] Pimentel AM,Pereira NR,Costa CA,et al.L-arginine-nitric oxide pathway and oxidative stress in plasma and platelets of patients with pre-eclampsia[J].Hypertension Research,2013,36(9):783-788.
[11] Herrera-Garcia G,Contag S.Maternal preeclampsia and risk for cardiovascular disease in offspring[J].Current Hypertension Reports,2014,16(9):475.
[12] Bener A,Saleh NM.The impact of socio-economic,lifestyle habits,andobesity in developing of pregnancy-induced hypertension in fast-growing country:global comparisons[J].Clinical and Experimental Obstetrics & Gynecology,2012,40(1):52-57.
[13] Khalil AA,Tsikas D,Akolekar R,et al.Asymmetric dimethylarginine,arginine and homoarginine at 11-13 weeks' gestation and preeclampsia:a case-control study[J].Journal of Human Hypertension,2013,27(1):38-43.
[14] 顾益凤,朱自力,张金业,等.利用ROC曲线选择血清HE-4对卵巢癌的最佳诊断界点[J].现代检验医学杂志,2015,30(4):141-143. Gu YF,Zhu ZL,Zhang JY,et al.Selecting the best cut-off point of serumHE-4 in ovarian cancer by ROC curve[J].J Mod Lab Med,2015,30(4):141-143.

相似文献/References:

[1]潘秀林a,朱玩秀b.妊高症患者血清CysC,HCY及mALB联合检测的临床意义[J].现代检验医学杂志,2015,30(03):145.[doi:10.3969/j.issn.1671-7414.2015.03.044]
　PAN Xiu-lina,ZHU Wan-xiub.Clinical Significance of Serum Cys C,HCY and mALB Joint Detection to HDCP Patients[J].Journal of Modern Laboratory Medicine,2015,30(04):145.[doi:10.3969/j.issn.1671-7414.2015.03.044]

备注/Memo

备注/Memo:
基金项目:陕西省教育厅自然科学研究项目,编号2013JK0782。 作者简介:汪海瑛(1983-),女,本科,主治医师,研究方向:妇产科常见病的研究,E-mail:wanghaiying19834@126.com。
更新日期/Last Update: 1900-01-01