[1]田文静,刘电力,刘惠敏,等.人血清幽门螺杆菌SodB抗体检测与胃癌发生的相关性研究[J].现代检验医学杂志,2018,33(01):22-24.[doi:10.3969/j.issn.1671-7414.2018.01.001]
　TIAN Wen-jing,LIU Dian-li,LIU Hui-min,et al.Correlative Study between Detection of Human Serum Helicobacter Pylori SodB Antibody and the Occurrence of Gastric Cancer[J].Journal of Modern Laboratory Medicine,2018,33(01):22-24.[doi:10.3969/j.issn.1671-7414.2018.01.001]
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人血清幽门螺杆菌SodB抗体检测与胃癌发生的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年01期
页码:
22-24
栏目:
论著
出版日期:
2018-02-05

文章信息/Info

Title:
Correlative Study between Detection of Human Serum Helicobacter Pylori SodB Antibody and the Occurrence of Gastric Cancer
文章编号:
1671-7414(2018)01-022-03
作者:
田文静1; 刘电力1; 刘惠敏2; 范 清3; 谢文珍1; 东英子1
1.哈尔滨医科大学公共卫生学院, 哈尔滨 150081; 2.哈尔滨医科大学第四附属医院神经内科,哈尔滨 150001; 3.哈尔滨市香坊区疾病预防控制中心,哈尔滨 150046
Author(s):
TIAN Wen-jing1; LIU Dian-li1; LIU Hui-min2; FAN Qing3; XIE Wen-zhen1; DONG Ying-zi1
1.College of Public Health,Harbin Medical University,Harbin 150081,China; 2.Department of Neurology,the Forth Affiliated Hospital of Harbin Medical University,Harbin 150001,China; 3.Xiangfang Center for Disease Control and Prevention in Harbin,Harbin 150046,China
关键词:
胃癌;  幽门螺杆菌;  铁辅因子超氧化物歧化酶;  血清抗体;  病例对照研究
分类号:
R735.2; R730.43
DOI:
10.3969/j.issn.1671-7414.2018.01.001
文献标志码:
A
摘要:
目的 探讨由幽门螺杆菌(Helicobacter pylori,H.pylori)基因组编码产生铁辅因子超氧化物歧化酶(SodB)人群血清抗体水平与胃癌发生的关系。方法 收集114例病例和104例对照的血清样本。用间接ELISA检测病例组和对照组的人群血清SodB抗体水平。应用条件Logistic回归方法分析SodB血清抗体水平与胃癌的关系。应用受试者工作特征曲线(ROC曲线)分析并评价SodB在胃癌血清学筛查中的价值。结果 在研究人群中,血清SodB抗体水平与胃癌发生有关(P<0.05)(OR=2.287,95%CI:1.191～4.391)。应用ROC曲线确定SodB筛查胃癌的最佳临界值为0.028 0。研究人群ROC曲线下面积为0.575(95%CI:0.501～0.649)。结论 血清H.pylori SodB抗体水平与胃癌发生有关,单独应用SodB对胃癌进行筛查的效果不理想,与其他胃癌生物标志物联合应用或许可进一步提高胃癌筛查价值。
Abstract:
Abstract:Objective To investigate the relationship between the level of serum iron-cofactored superoxide dismutase(SodB)antibody encoded by Helicobacter pylori(H.pylori) genome in infected populations of H.pylori and the occurrence of gastric cancer.Methods Serum samples from 114 cases and 104 control were collected.Indirect ELISA wasused to detect serum SodB antibody level in case group and control group.The relationship between serum SodB antibody level and GC risk was analyzed by conditional logistic regression.The value of SodB in serological screening of gastriccancer was analyzed and evaluated by the receiver operating characteristic(ROC)curve.Results The level of serum SodB antibody was correlated with the occurrence of gastric cancer in subjects with OR=2.287(95%CI:1.191～4.391)(P<0.05).The optimal cutoff value of SodB for screening gastric cancer was determined by using receiver operating characteristic(ROC)curve,and it was 0.028 0.The area under the ROC curve for subjects was 0.575(95%CI:0.501～0.649).Conclusion The level of serum H.pylori SodB antibody was associated with the occurrence of gastric cancer.SodB alone was not effective in screening gastric cancer.It might be used in combination with other biomarkers of gastric cancer to improve further screening ofgastric cancer.

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备注/Memo

备注/Memo:
基金项目:黑龙江省教育厅科学技术研究项目面上项目(项目编号:12541288)。 作者简介:田文静(1973-),女,博士,哈尔滨医科大学公共卫生学院教授,研究方向:恶性肿瘤流行病学,E-mail:twj8267@sina.com。 通讯作者:东英子(1990-),女,硕士,研究方向:恶性肿瘤流行病学,E-mail:donglele1990@sina.com。
更新日期/Last Update: 2018-02-07