[1]申文娟,李园春,姚若冰.孕前和孕期母体外周血血红蛋白浓度与发生胎儿死产风险的相关性研究[J].现代检验医学杂志,2019,34(04):139-142.[doi:10.3969/j.issn.1671-7414.2019.04.034]
　SHEN Wen-juan,LI Yuan-chun,YAO Ruo-bing.Correlation between Maternal Peripheral Blood Hemoglobin Concentration and Risk of Fetal Stillbirth before and During Pregnancy[J].Journal of Modern Laboratory Medicine,2019,34(04):139-142.[doi:10.3969/j.issn.1671-7414.2019.04.034]
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孕前和孕期母体外周血血红蛋白浓度与发生胎儿死产风险的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年04期
页码:
139-142
栏目:
检验与临床
出版日期:
2019-08-20

文章信息/Info

Title:
Correlation between Maternal Peripheral Blood Hemoglobin Concentration and Risk of Fetal Stillbirth before and During Pregnancy
文章编号:
1671-7414(2019)04-139-05
作者:
申文娟1; 李园春2; 姚若冰1
(1.宝鸡市高新人民医院产科,陕西宝鸡 721000; 2.宝鸡市妇幼保健院产科,陕西宝鸡 721000)
Author(s):
SHEN Wen-juan1; LI Yuan-chun2; YAO Ruo-bing1
(1.Department of Obstetrics, Baoji High-tech People's Hospital,Shaanxi Baoji 721000,China; 2.Department of Obstetrics,Baoji Maternal and Child Health Hospital,Shaanxi Baoji 721000,China)
关键词:
妊娠;  外周血;  血红蛋白;  死产
分类号:
R714.4; R446.11
DOI:
10.3969/j.issn.1671-7414.2019.04.034
文献标志码:
A
摘要:
目的 研究孕前和孕期母体外周血血红蛋白(Hb)浓度与发生胎儿死产风险间的关系。方法 选取2015年1月～2017年12月在陕西省宝鸡市高新人民医院经妊娠期≥28周分娩时发生胎儿死产的12例孕妇作为实验组,选取同期胎儿安全出生的孕妇246例作为对照组。使用多变量逻辑回归模型,评估妊娠不同阶段母体外周血Hb浓度和稀释情况与发生死产风险的比值比(OR)及95%的置信区间。结果 孕前母体外周血Hb浓度与胎儿死产之间没有相关性。在妊娠中期结束时外周血Hb浓度过高(≥140 g/L)的孕妇发生胎儿死产的风险比Hb浓度为正常值(110～120g/L)的孕妇高出两倍多(OR=2.32); 而Hb浓度较低(<110 g/L)的孕妇,发生死产的风险下降了29%。在妊娠期或仅在妊娠中期降低母体外周血Hb浓度均可以降低死产风险。结论 孕前母体外周血Hb浓度与死产没有相关性。妊娠期高浓度Hb以及血红蛋白缺乏稀释可作为高危妊娠的一个信号。
Abstract:
Objective To study the associations between maternal haemoglobin concentrations and the risk of stillbirth before and during pregnancy.Methods Selected births from January 2015 to December 2017 in Baoji High-tech People's Hospital in Shaanxi Province,including12 primiparous women with stillbirths(cases group)occurring at 28 weeks' gestation or later and 246 primiparous women with live births(control group).Using multivariate logistic regression models to estimate odds ratios(ORs)and 95%confidence intervals(CIs)for the associations of maternal haemoglobin concentrations and haemoglobin dilution at different stages of pregnancy,with stillbirth risk.Results Haemoglobin concentration before pregnancy was not associated with stillbirth risk.Compared with normal maternal haemoglobin concentration(110～120 g/L)at the end of the second trimester,high maternal haemoglobin concentration(≥140 g/L)was associated with a more than two-fold increased stillbirth risk(OR=2.32),while low maternal haemoglobin concentration(<110 g/L)was associated with a 29% reduction in stillbirth risk.Decreased haemoglobin concentration,as measured during pregnancy,or only during thesecond trimester,were associated with reduced stillbirth risk.Conclusion Haemoglobin concentration before pregnancy was not associatedwith stillbirth risk.High haemoglobin level and absence of haemoglobin dilutionduring pregnancy could be considered as indicators of a high-risk pregnancy.

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备注/Memo

备注/Memo:
基金项目:陕西省卫生厅科研项目(项目编号:2014-D27)。 作者简介:申文娟(1971-),女,本科,副主任医师,研究方向:产后抑郁症、妊高症,E-mail:baoshenwenj@163.com。 通讯作者:姚若冰(1984-),女,本科,主治医师,E-mail:278623648@qq.com。收稿日期:2019-02-13 修回日期:2019-04-25
更新日期/Last Update: 2019-07-30